FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\f3N
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General Information
Symbol
Dmel\f3N
Species
D. melanogaster
Name
FlyBase ID
FBal0003946
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Intragenic duplication of 2.8kb genomic DNA causing a duplication of exon 3.

A member of the left hand group of alleles. Shown to contain a 2.8 kb tandem repeat, but to the right of f1 according to the orientation on the chromosome as determined by Parkhurst and Corces (1985) (McLachlan, 1986). A revertant of f3N retains the repeated sequence.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Denticles of all rows display normal arrangement and polarity but they are thin and sinuous ('goose-necked') compared with the stout hooks seen in wild type. The normally stout triangular hairs near the anterior margins of segments exhibit a similar phenotype. Longer hairs are close to normal but typically are not as straight, uniformly tapered and pointed as wild type.

A dominant cis-acting enhancer of the reversion rate of f3N; thought to be at least partially responsible for reported instability of f3N. Does not increase the frequency of sex-linked lethal mutations. Has no effect on the reversion frequencies of mutations in v, car, y, w, m, Bx or B.

Expression similar to f but unlike f, does not respond to su(f). Characterized by a high spontaneous reversion rate (~2 x 10-5); rate may be further increased by a closely linked cis-dominant mutator allele, Mu(f3N), (5 x; Woodruff, 1975), by X rays (20 x; Green, 1977) and by mustard gas (Woodruff, Bowman and Simmons, 1972). not suppressed by su(f). RK1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Green.

Comments
Comments

Mutation can spontaneously revert to wild type, frequency of reversion can be increased by X ray irradiation.

External Crossreferences and Linkouts ( 6 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
f3N
Name Synonyms
Secondary FlyBase IDs
    References (7)