FB2022_02, released March 29, 2022

Allele: Dmel\Sb1

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General Information
Symbol
Dmel\Sb1
Species
D. melanogaster
Name
FlyBase ID
FBal0015145
Feature type
allele
Associated gene
Dmel\Sb
Associated Insertion(s)
412{}Sb1
Carried in Construct
Also Known As
Sb
Key Links
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Gotwals and Fristrom, 1991)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
transposable_element_insertion_site
3R:16,141,939..16,141,942
(Miller et al., 2016, Hammonds and Fristrom, 2006)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology

      Polytene chromosomes normal (Morgan, Bridges and Schultz, 1937).

      Nature of the lesion
      Statement
      Reference

      Insertion of a 412 element in the 4th coding exon of Sb (coordinates 3R:16141939..16141942 , release 6 genome).

      (Miller et al., 2016)

      Insertion of a blood element in the 3' region of Sb, which results in a truncated transcript of approximately 2.8kb.

      (Hammonds and Fristrom, 2006)

      Insertion between -55.5 and -57kb.

      (Appel et al., 1993)
      Insertion components
      412{}Sb1
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes have ocellar bristles which are shorter and have a smaller volume than normal.

      (Fei et al., 2002)

      Heterozygotes have denticles that are smaller, thinner and more variable in size and shape than those in wild type. Hairs appear normal.

      (Dickinson and Thatcher, 1997)

      Sb1, T(2;3)SbV, and SbSpi are much less severe in phenotype, both in bristle length and frequency and severity of malformation of appendages, than Sb63b and Sb70.

      (Appel, 1995)

      Sb1/Sb- is viable, though poorly so.

      (Nelson and Szauter, 1992)

      Leg discs do not elongate properly in Sb1/Sb63b flies; cells in the basitarsus and tibia do not extend normally and cells in this region remain highly anisometric in shape.

      (Condic et al., 1991)

      zip interacts to some degree with all Sb dominant mutations.

      (Gotwals and Fristrom, 1991)

      Sb1/Sbsbd-2 are more extreme than Sb1/+. Sbsbd-2, Sb1 behaves as a recessive 'sbd' allele but is homozygous lethal; rare escapers more extreme and easy to recognize.

      (Davis, 1971)

      intermediate allele Bristles of Sb/+ less than one-half normal length and somewhat thicker than wild type. Fiber bundles in bristle shafts smaller and more numerous than in wild type; occupy a third as much of the bristle cross-sectional area in Sb as in wild type (Overton, 1967; FBrf0018805). Developmental studies by Lees and Waddington (FBrf0005804) show that trichogen is shifted to lie more or less on the level of the tormogen.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Rho1J3.8, Sb[+]/Sb1 has visible phenotype

      (Bayer et al., 2003)

      Df(2R)Jp8/+, Sb1 has visible | dominant phenotype

      (Bayer et al., 2003)

      Rho1J3.8/Rho1[+], Sb1 has visible | dominant phenotype

      (Bayer et al., 2003)

      Bsb2, Sb[+]/Sb1 has visible | dominant phenotype

      (Fei et al., 2002)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Sb1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Suppressor of
      Statement
      Reference

      Sb1 is a suppressor of phenotype of Cu-31

      (Meyer, 1952)
      Other
      Statement
      Reference

      Rho1J3.8, Sb1 has leg phenotype

      (Bayer et al., 2003)

      Df(2R)Jp8/+, Sb1 has leg phenotype

      (Bayer et al., 2003)

      Rho1J3.8/Rho1[+], Sb1 has leg phenotype

      (Bayer et al., 2003)

      Bsb2, Sb[+]/Sb1 has ocellar bristle phenotype

      (Fei et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Sb1 shows a weak interaction (5-24% of double heterozygotes have at least one malformed leg) with the following mutations: Rho1J3.8 and Df(2R)Jp8.

      (Bayer et al., 2003)

      Sb1 Bsb2 double heterozygotes have ocellar bristles which are shorter and have a smaller volume than normal.

      (Fei et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (1)
      Stocks (12,007)
      Notes on Origin
      Discoverer

      Bridges, 21st April 1923.

      Associated with: l(3)89Aa1.

      (Appel, 1995)
      Comments
      Comments

      Insertion remains in 5 (unnamed) Sb1 revertants.

      (Appel et al., 1993)

      The lethality of Sb1 is probably not due to Sb, but to a second mutation on the same chromosome called l(3)89Aa1.

      (Appel, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sb
      (Fei et al., 2002, Meyer, 1952)
      Sb1
      (Miller et al., 2016, Harumoto et al., 2014, Hammonds and Fristrom, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (38)