FlyBase Allele Report: Dmel\Sb[1]

General Information

Symbol

Dmel\Sb¹

Species

D. melanogaster

Name

FlyBase ID

FBal0015145

Feature type

allele

Associated gene

Dmel\Sb

Associated Insertion(s)

412{}Sb¹

Carried in Construct

Also Known As

Key Links

Genomic Maps

GBrowse JBrowse

Help me choose

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Gotwals and Fristrom, 1991)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:16,141,939..16,141,942

(Miller et al., 2016, Hammonds and Fristrom, 2006)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Polytene chromosomes normal (Morgan, Bridges and Schultz, 1937).

Nature of the lesion

Statement

Reference

Insertion of a 412 element in the 4th coding exon of Sb (coordinates 3R:16141939..16141942 , release 6 genome).

(Miller et al., 2016)

Insertion of a blood element in the 3' region of Sb, which results in a truncated transcript of approximately 2.8kb.

(Hammonds and Fristrom, 2006)

Insertion between -55.5 and -57kb.

(Appel et al., 1993)

Insertion components

412{}Sb¹

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Nelson and Szauter, 1992)

partially lethal (with Sb^63b)

(Hammonds and Fristrom, 2006)

partially lethal - majority die

visible

(Dickinson and Thatcher, 1997)

visible | dominant

(Hammonds and Fristrom, 2006, Fei et al., 2002, Nelson and Szauter, 1992)

Phenotype Manifest In

chaeta

(Hammonds and Fristrom, 2006)

denticle belt

(Dickinson and Thatcher, 1997)

macrochaeta

(Nelson and Szauter, 1992)

metatarsus

(Condic et al., 1991)

ocellar bristle

(Fei et al., 2002)

tibia

(Condic et al., 1991)

ventral thoracic disc

(Condic et al., 1991)

Detailed Description

Statement

Reference

Heterozygotes have ocellar bristles which are shorter and have a smaller volume than normal.

(Fei et al., 2002)

Heterozygotes have denticles that are smaller, thinner and more variable in size and shape than those in wild type. Hairs appear normal.

(Dickinson and Thatcher, 1997)

Sb¹, T(2;3)Sb^V, and Sb^Spi are much less severe in phenotype, both in bristle length and frequency and severity of malformation of appendages, than Sb^63b and Sb⁷⁰.

(Appel, 1995)

Sb¹/Sb^- is viable, though poorly so.

(Nelson and Szauter, 1992)

Leg discs do not elongate properly in Sb¹/Sb^63b flies; cells in the basitarsus and tibia do not extend normally and cells in this region remain highly anisometric in shape.

(Condic et al., 1991)

zip interacts to some degree with all Sb dominant mutations.

(Gotwals and Fristrom, 1991)

Sb¹/Sb^sbd-2 are more extreme than Sb¹/+. Sb^sbd-2, Sb¹ behaves as a recessive 'sbd' allele but is homozygous lethal; rare escapers more extreme and easy to recognize.

(Davis, 1971)

intermediate allele Bristles of Sb/+ less than one-half normal length and somewhat thicker than wild type. Fiber bundles in bristle shafts smaller and more numerous than in wild type; occupy a third as much of the bristle cross-sectional area in Sb as in wild type (Overton, 1967; FBrf0018805). Developmental studies by Lees and Waddington (FBrf0005804) show that trichogen is shifted to lie more or less on the level of the tormogen.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Rho1^J3.8, Sb[+]/Sb¹ has visible phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb¹ has visible | dominant phenotype

(Bayer et al., 2003)