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General Information
Symbol
Dmel\Sb1
Species
D. melanogaster
Name
FlyBase ID
FBal0015145
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Sb
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal (Morgan, Bridges and Schultz, 1937).

Nature of the lesion
Statement
Reference

Insertion of a 412 element in the 4th coding exon of Sb (coordinates 3R:16141939..16141942 , release 6 genome).

Insertion of a blood element in the 3' region of Sb, which results in a truncated transcript of approximately 2.8kb.

Insertion between -55.5 and -57kb.

Insertion components
412{}Sb1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes have ocellar bristles which are shorter and have a smaller volume than normal.

Heterozygotes have denticles that are smaller, thinner and more variable in size and shape than those in wild type. Hairs appear normal.

Sb1, T(2;3)SbV, and SbSpi are much less severe in phenotype, both in bristle length and frequency and severity of malformation of appendages, than Sb63b and Sb70.

Sb1/Sb- is viable, though poorly so.

Leg discs do not elongate properly in Sb1/Sb63b flies; cells in the basitarsus and tibia do not extend normally and cells in this region remain highly anisometric in shape.

zip interacts to some degree with all Sb dominant mutations.

Sb1/Sbsbd-2 are more extreme than Sb1/+. Sbsbd-2, Sb1 behaves as a recessive 'sbd' allele but is homozygous lethal; rare escapers more extreme and easy to recognize.

intermediate allele Bristles of Sb/+ less than one-half normal length and somewhat thicker than wild type. Fiber bundles in bristle shafts smaller and more numerous than in wild type; occupy a third as much of the bristle cross-sectional area in Sb as in wild type (Overton, 1967; FBrf0018805). Developmental studies by Lees and Waddington (FBrf0005804) show that trichogen is shifted to lie more or less on the level of the tormogen.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference

Rho1J3.8, Sb[+]/Sb1 has visible phenotype

Rho1J3.8/Rho1[+], Sb1 has visible | dominant phenotype

Bsb2, Sb[+]/Sb1 has visible | dominant phenotype

Phenotype Manifest In
NOT suppressed by
Statement
Reference

Sb1 has phenotype, non-suppressible by su(Hw)2

Suppressor of
Statement
Reference

Sb1 is a suppressor of phenotype of Cu-31

Other
Statement
Reference

Rho1J3.8/Rho1[+], Sb1 has leg phenotype

Additional Comments
Genetic Interactions
Statement
Reference

Sb1 shows a weak interaction (5-24% of double heterozygotes have at least one malformed leg) with the following mutations: Rho1J3.8 and Df(2R)Jp8.

Sb1 Bsb2 double heterozygotes have ocellar bristles which are shorter and have a smaller volume than normal.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (1)
Stocks (11,825)
Notes on Origin
Discoverer

Bridges, 21st April 1923.

Associated with: l(3)89Aa1.

Comments
Comments

Insertion remains in 5 (unnamed) Sb1 revertants.

The lethality of Sb1 is probably not due to Sb, but to a second mutation on the same chromosome called l(3)89Aa1.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (38)