FlyBase Allele Report: Dmel\Rho1[J3.8]

General Information

Symbol

Dmel\Rho1^J3.8

Species

D. melanogaster

Name

FlyBase ID

FBal0090395

Feature type

allele

Associated gene

Dmel\Rho1

Associated Insertion(s)

Carried in Construct

Also Known As

RhoA^J3.8

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q180term.

(Halsell et al., 2000)

Nucleotide substitution: C?T.

(Halsell et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:16,106,010..16,106,010 [+]

Nucleotide change:

C16106010T

Reported nucleotide change:

C?T

Amino acid change:

Reported amino acid change:

Q180term

(Halsell et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Rho1^12-6)

(Bayer et al., 2003)

lethal | recessive

(Halsell and Kiehart, 1998)

lethal - all die during embryonic stage | recessive

(Halsell et al., 2000)

some die during embryonic stage | recessive

(Halsell et al., 2000)

Phenotype Manifest In

embryonic/first instar larval cuticle | anterior | dorsal

(Halsell et al., 2000)

embryonic/first instar larval cuticle | anterior | dorsal (with Rho1^E3.10)

(Halsell et al., 2000)

Detailed Description

Statement

Reference

Homozygous and Rho1^E3.10/Rho1^J3.8 embryos have dorsal anterior holes in their cuticle.

(Halsell et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Rho1^J3.8/Rho1[+] is an enhancer of visible phenotype of br¹

(Ward et al., 2003)

Suppressor of

Statement

Reference

Rho1^J3.8/Rho1[+] is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Rho1^J3.8/Rho1[+] is a suppressor of lethal | recessive | partially | embryonic stage phenotype of peb³⁰⁸

(Wilk et al., 2004)

Other

Statement

Reference

Rho1^J3.8/Rho1[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6, Rho1^J3.8/Rho1[+] has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Rok¹ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^11-3 has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^11-3 has partially lethal phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Rho1^J3.8/Rho1[+] has visible | dominant phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Rho1^J3.8/Rho1[+] has partially lethal phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Rho1^J3.8/Rho1[+] has visible | dominant phenotype

(Bayer et al., 2003)

Df(3R)sbd105/+, Rho1^J3.8 has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8, br¹ has visible | cold sensitive phenotype

(Bayer et al., 2003)

E(zip)12-5[+]/E(zip)12-5^12-5, Rho1^J3.8 has visible phenotype

(Bayer et al., 2003)

E(zip)18-5[+]/E(zip)18-5^18-5, Rho1^J3.8 has visible phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6/E(zip)31-6[+], Rho1^J3.8 has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, RhoGEF2⁰⁴²⁹¹/RhoGEF2[+] has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, RhoGEF2^1.1/RhoGEF2[+] has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, RhoGEF2^11-3/RhoGEF2[+] has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, RhoGEF2^4.1/RhoGEF2[+] has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb[+]/Sb¹ has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^63b/Sb[+] has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb[+]/Sb^Spi has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, rok[+]/Rok¹ has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, rok[+]/Rok² has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, zip^33-1/zip[+] has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2⁰⁴²⁹¹ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^1.1 has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^4.1 has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb¹ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^63b has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^Spi has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], br¹ has visible | cold sensitive phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Rok² has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], zip^33-1 has visible | dominant phenotype

(Bayer et al., 2003)

E(br)121^Ebr121, Rho1^J3.8/Rho1[+] has visible | dominant phenotype

(Ward et al., 2003)

Mcr¹, Rho1^J3.8/Rho1[+] has visible | dominant phenotype

(Ward et al., 2003)

E(br)121^Ebr121/E(br)121[+], Rho1^J3.8 has visible phenotype

(Ward et al., 2003)

E(br)155[+]/Mcr¹, Rho1^J3.8 has visible phenotype

(Ward et al., 2003)

E(br)420[+]/E(br)420^Ebr420, Rho1^J3.8 has visible phenotype

(Ward et al., 2003)

E(br)444[+]/E(br)444^Ebr444, Rho1^J3.8 has visible phenotype

(Ward et al., 2003)

E(br)65^Ebr65/E(br)65[+], Rho1^J3.8 has visible phenotype

(Ward et al., 2003)

Rho1^J3.8, Sb^Ebr623/Sb[+] has visible phenotype

(Ward et al., 2003)

E(br)420^Ebr420, Rho1^J3.8/Rho1[+] has visible | dominant phenotype

(Ward et al., 2003)

E(br)444^Ebr444, Rho1^J3.8/Rho1[+] has visible | dominant phenotype

(Ward et al., 2003)

E(br)65^Ebr65, Rho1^J3.8/Rho1[+] has visible | dominant phenotype

(Ward et al., 2003)

Rho1^J3.8/Rho1[+], Sb^Ebr623 has visible | dominant phenotype

(Ward et al., 2003)

Rho1^J3.8, zip[+]/zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000, Halsell and Kiehart, 1998)

Rho1^J3.8, zip^Ebr has visible | dominant phenotype

(Halsell et al., 2000)

Rho1^J3.8, zip^Ebr has partially lethal - majority die | dominant phenotype

(Halsell et al., 2000)

Rho1^J3.8, zip[+]/zip^Ebr has partially lethal - majority die | dominant phenotype

(Halsell et al., 2000)

Df(2R)Jp1/+, Rho1^J3.8 has visible | dominant phenotype

(Halsell et al., 2000)

Rho1^J3.8/Rho1[+], zip^Ebr has partially lethal - majority die | dominant phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8, zip[+]/zip^Ebr has partially lethal - majority live phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8/Rho1[+], zip^Ebr has visible | dominant phenotype

(Halsell and Kiehart, 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Rho1^J3.8/Rho1[+] is an enhancer of leg phenotype of br¹

(Ward et al., 2003)

Suppressor of

Statement

Reference

Rho1^J3.8/Rho1[+] is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Other

Statement

Reference

E(zip)31-6^31-6, Rho1^J3.8/Rho1[+] has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Rok¹ has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^11-3 has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Rho1^J3.8/Rho1[+] has wing phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Rho1^J3.8/Rho1[+] has leg phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6, Rho1^J3.8/Rho1[+] has leg phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Rho1^J3.8/Rho1[+] has wing phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Rho1^J3.8/Rho1[+] has leg phenotype

(Bayer et al., 2003)

Df(3R)sbd105/+, Rho1^J3.8 has leg phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Rho1^J3.8 has wing phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Rho1^J3.8 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, RhoGEF2^11-3 has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8, RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, br¹ has leg | cold sensitive phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Rho1^J3.8 has wing phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Rho1^J3.8 has leg phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6, Rho1^J3.8 has wing phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6, Rho1^J3.8 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, RhoGEF2⁰⁴²⁹¹ has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, RhoGEF2^1.1 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, RhoGEF2^4.1 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb¹ has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^63b has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^63b has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^Spi has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Rok¹ has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Rok² has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, zip^33-1 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2⁰⁴²⁹¹ has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^1.1 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^4.1 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb¹ has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^63b has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^63b has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^Spi has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], br¹ has leg | cold sensitive phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Rok² has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], zip^33-1 has leg phenotype

(Bayer et al., 2003)

E(br)121^Ebr121, Rho1^J3.8/Rho1[+] has leg phenotype

(Ward et al., 2003)

E(br)121^Ebr121, Rho1^J3.8 has leg phenotype

(Ward et al., 2003)

Mcr¹, Rho1^J3.8 has leg phenotype

(Ward et al., 2003)

E(br)420^Ebr420, Rho1^J3.8 has leg phenotype

(Ward et al., 2003)

Mcr¹, Rho1^J3.8/Rho1[+] has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, Rho1^J3.8 has leg phenotype

(Ward et al., 2003)

E(br)65^Ebr65, Rho1^J3.8 has leg phenotype

(Ward et al., 2003)

Rho1^J3.8, Sb^Ebr623 has leg phenotype

(Ward et al., 2003)

E(br)420^Ebr420, Rho1^J3.8/Rho1[+] has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, Rho1^J3.8/Rho1[+] has leg phenotype

(Ward et al., 2003)

E(br)65^Ebr65, Rho1^J3.8/Rho1[+] has leg phenotype

(Ward et al., 2003)

Rho1^J3.8/Rho1[+], Sb^Ebr623 has leg phenotype

(Ward et al., 2003)

Rho1^J3.8, zip^Ebr has leg phenotype

(Halsell et al., 2000)

Rho1^J3.8, zip[+]/zip^Ebr has leg phenotype

(Halsell et al., 2000)

Rho1^J3.8/Rho1[+], zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8/Rho1[+], zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8, zip[+]/zip^Ebr has femur phenotype

(Halsell and Kiehart, 1998)

Rho1^J3.8, zip[+]/zip^Ebr has tibia phenotype

(Halsell and Kiehart, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Rho1^J3.8 shows a strong interaction (at least 50% of double heterozygotes have at least one malformed leg) with the following mutations: RhoGEF2^11-3, E(zip)12-5^12-5, E(zip)18-5^18-5, E(zip)31-6^31-6, zip^33-1, Sb^63b and Sb⁷⁰. Rho1^J3.8 shows a moderate interaction (25-49% of double heterozygotes have at least one malformed leg) with the following mutations: Df(3R)sbd105. Rho1^J3.8 shows a weak interaction (5-24% of double heterozygotes have at least one malformed leg) with the following mutations: Sb¹, Sb^Spi. Rho1^J3.8 shows no interaction with sqh^unspecified (assayed in terms of a malformed leg phenotype). Rho1^J3.8 shows a strong interaction (at least 50% of double heterozygotes have at least one malformed wing) with the following mutations: Sb^63b, Sb⁷⁰, RhoGEF2^11-3 and E(zip)12-5^12-5. Rho1^J3.8 shows a moderate interaction (25-49% of double heterozygotes have at least one malformed wing) with the following mutations: E(zip)18-5^18-5 and E(zip)31-6^31-6. Sb^sbd-201/Sb^sbd-1 shows a strong interaction (at least 50% of double mutants have at least one malformed leg) with the following mutations: Rho1^J3.8/+.

(Bayer et al., 2003)

Dominantly enhances the frequency of br¹ mutant animals with malformed legs. The fraction of flies showing a malformed leg phenotype in at least one leg, for Rho1^J3.8 in double heterozygous combination with one of the following alleles is - Sb^Ebr20 : 16%, Sb^Ebr48 : 15%, Sb^Ebr228 : 3%, Sb^Ebr448 : 15%, Sb^Ebr536 : 19%, Sb^Ebr623 : 21%, bs^Ebr292 : 7%, E(br)24^Ebr24 : 11%, E(br)65^Ebr65 : 28%, E(br)155^Ebr155 : 57%, E(br)165^Ebr165 : 15%, E(br)333^Ebr333 : 1%, E(br)72^Ebr72 : 16%, E(br)121^Ebr121 : 37%, E(br)160^Ebr160 : 7%, E(br)187^Ebr187 : 1%, E(br)420^Ebr420 : 21% and E(br)444^Ebr444 : 29%.

(Ward et al., 2003)

100% of Rho1^J3.8/zip^Ebr double heterozygotes have a malformed leg phenotype. 19% of Rho1^J3.8/Df(2R)Jp1 double heterozygotes show a malformed phenotype.

(Halsell et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Rho1^12-6

(Bayer et al., 2003)

Rho1^Ebr233

(Ward et al., 2003)

Rho1^Ebr246

(Ward et al., 2003)