FlyBase Allele Report: Dmel\E(br)444[Ebr444]

General Information

Symbol

Dmel\E(br)444^Ebr444

Species

D. melanogaster

Name

FlyBase ID

FBal0156617

Feature type

allele

Associated gene

E(br)444

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ward et al., 2003)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | recessive

(Ward et al., 2003)

lethal | larval stage | recessive

(Ward et al., 2003)

visible | semidominant

(Ward et al., 2003)

Phenotype Manifest In

leg

(Ward et al., 2003)

Detailed Description

Statement

Reference

9% of heterozygotes show a malformed leg phenotype. Homozygotes show 21 +/- 2% embryonic lethality and 100% of homozygous larvae fail to form pupae. Homozygous embryos have no discernible mutant phenotype.

(Ward et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

E(br)444[+]/E(br)444^Ebr444 is an enhancer of visible phenotype of br¹

(Ward et al., 2003)

Other

Statement

Reference

E(br)444^Ebr444, Rho1^J3.8/Rho1[+] has visible | dominant phenotype

(Ward et al., 2003)

E(br)444^Ebr444, br⁵/br[+] has visible | dominant phenotype

(Ward et al., 2003)

E(br)444[+]/E(br)444^Ebr444, Rho1^J3.8 has visible phenotype

(Ward et al., 2003)

E(br)444[+]/E(br)444^Ebr444, Rho1^k02107b has visible phenotype

(Ward et al., 2003)

E(br)444[+]/E(br)444^Ebr444, RhoGEF2⁰⁴²⁹¹ has visible phenotype

(Ward et al., 2003)

E(br)444[+]/E(br)444^Ebr444, br⁵ has visible phenotype

(Ward et al., 2003)

E(br)444^Ebr444, Rho1[+]/Rho1^k02107b has visible | dominant phenotype

(Ward et al., 2003)

E(br)444[+]/E(br)444^Ebr444, zip^Ebr has visible phenotype

(Ward et al., 2003)

E(br)444[+]/E(br)444^Ebr444, RhoGEF2^11-3 has visible phenotype

(Ward et al., 2003)

E(br)444^Ebr444, RhoGEF2⁰⁴²⁹¹/RhoGEF2[+] has visible | dominant phenotype

(Ward et al., 2003)

E(br)444^Ebr444, RhoGEF2^11-3/RhoGEF2[+] has visible | dominant phenotype

(Ward et al., 2003)

E(br)444^Ebr444, zip[+]/zip^Ebr has visible | dominant phenotype

(Ward et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

E(br)444[+]/E(br)444^Ebr444 is an enhancer of leg phenotype of br¹

(Ward et al., 2003)

Other

Statement

Reference

E(br)444^Ebr444, Rho1^J3.8/Rho1[+] has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, br⁵/br[+] has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, Rho1^J3.8 has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, Rho1^k02107b has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, RhoGEF2⁰⁴²⁹¹ has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, br⁵ has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, zip^Ebr has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, RhoGEF2^11-3 has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, Rho1[+]/Rho1^k02107b has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, RhoGEF2⁰⁴²⁹¹/RhoGEF2[+] has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, RhoGEF2^11-3/RhoGEF2[+] has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, zip[+]/zip^Ebr has leg phenotype

(Ward et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

27% of br¹ ; E(br)444^Ebr444/+ flies show a malformed leg phenotype. The predominant leg phenotype in br¹/Y ; E(br)444^Ebr444/+ flies is a moderate to strong bend in the mid-tibia not associated with an ectopic joint. 5% of br⁵/+ ; E(br)444^Ebr444/+ flies show a malformed leg phenotype. 29% of E(br)444^Ebr444 Rho1^J3.8 double heterozygotes show a malformed leg phenotype in at least one leg. 37% of E(br)444^Ebr444 Rho1^k02107b double heterozygotes show a malformed leg phenotype in at least one leg. 6% of E(br)444^Ebr444 Rho1^E3.10 double heterozygotes show a malformed leg phenotype in at least one leg. 36% of E(br)444^Ebr444 RhoGEF2⁰⁴²⁹¹ double heterozygotes show a malformed leg phenotype in at least one leg. 44% of E(br)444^Ebr444 RhoGEF2^11-3 double heterozygotes show a malformed leg phenotype in at least one leg. 84% of E(br)444^Ebr444 zip^Ebr double heterozygotes show a malformed leg phenotype in at least one leg. 1% of E(br)444^Ebr444 zip¹ double heterozygotes show a malformed leg phenotype in at least one leg. 4% of E(br)444^Ebr444 zip^33-1 double heterozygotes show a malformed leg phenotype in at least one leg.

(Ward et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a mutation that enhances the br¹ malformed leg phenotype.

(Ward et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

E(br)444

(Ward et al., 2003)

E(br)444^Ebr444

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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