FlyBase Allele Report: Dmel\in[II53]

General Information

Symbol

Dmel\in^II53

Species

D. melanogaster

Name

FlyBase ID

FBal0039447

Feature type

allele

Associated gene

Dmel\in

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Lee and Adler, 2002)

Mutagen

ethyl methanesulfonate

(Adler et al., 1994)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | heat sensitive

(Adler et al., 1994)

Phenotype Manifest In

macrochaeta | heat sensitive

(Adler et al., 1994)

wing hair & 1st posterior cell

(Lee and Adler, 2002)

Detailed Description

Statement

Reference

Mutant flies have an almost wild-type wing hair phenotype at 18^oC.

(Collier et al., 2005)

Mild multiple wing hair phenotype at 25^oC though not at 18^oC.

(Lee and Adler, 2002)

Viable as a homozygote or a hemizygote. Weak thoracic bristle and wing hair phenotype. Percentage of dorsal wing surface cells that display abnormal cell polarity and the percentage of wing cells forming more than one hair is more severe at 29^oC than 18^oC.

(Adler et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

in^II53 has abnormal planar polarity phenotype, enhanceable by frtz³

(Collier et al., 2005)

in^II53 has visible phenotype, enhanceable by frtz³

(Collier et al., 2005)

Enhancer of

Statement

Reference

in^II53 is an enhancer of visible phenotype of frtz³

(Collier et al., 2005)

in^II53 is an enhancer of abnormal planar polarity phenotype of frtz³

(Collier et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

in^II53 has wing hair | increased number phenotype, enhanceable by frtz³

(Collier et al., 2005)

in^II53 has wing hair phenotype, enhanceable by frtz³

(Collier et al., 2005)

in^II53 has wing hair & 1st posterior cell phenotype, enhanceable by fz²⁴

(Lee and Adler, 2002)

in^II53 has wing hair & 1st posterior cell phenotype, enhanceable by fz^HD21

(Lee and Adler, 2002)

in^II53 has wing hair & 1st posterior cell phenotype, enhanceable by fz^hs.PP

(Lee and Adler, 2002)

in^II53 has wing hair & 1st posterior cell phenotype, enhanceable by mwh[+]/mwh¹

(Lee and Adler, 2002)

in^II53 has wing hair & 1st posterior cell phenotype, enhanceable by pk¹

(Lee and Adler, 2002)

in^II53 has wing hair & 1st posterior cell phenotype, enhanceable by dsh¹

(Lee and Adler, 2002)

in^II53 has wing hair & 1st posterior cell phenotype, enhanceable by Vang^Tbs42

(Lee and Adler, 2002)

Enhancer of

Statement

Reference

in^II53 is an enhancer of wing hair | increased number phenotype of frtz³

(Collier et al., 2005)

in^II53 is an enhancer of wing hair phenotype of frtz³

(Collier et al., 2005)

in^II53 is an enhancer of wing hair phenotype of Vang^Tbs42

(Lee and Adler, 2002)

NOT Suppressor of

Statement

Reference

in¹/in^II53 is a non-suppressor of wing hair | heat sensitive phenotype of fz^hs.PP

(Lee and Adler, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

At 18^oC, in^II53 frtz³ double mutants have strong mutant polarity and hair number phenotypes in the wing hairs (while either single mutant has an almost wild-type wing hair phenotype at this temperature).

(Collier et al., 2005)

Late gain of function phenotype of fz^hs.PP is not suppressible by in^II53/in¹ or fy⁶.

(Lee and Adler, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

66523

w^*; in^II53

Notes on Origin

Discoverer

Comments

Weak in allele.

(Adler et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

in^II53

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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