FlyBase Allele Report: Dmel\Jra[76-19]

General Information

Symbol

Dmel\Jra^76-19

Species

D. melanogaster

Name

FlyBase ID

FBal0043601

Feature type

allele

Associated gene

Dmel\Jra

Associated Insertion(s)

Carried in Construct

Also Known As

76-19, jun^76-19

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Hou et al., 1997)

Mutagen

ethyl methanesulfonate

(Goldstein et al., 2001)

diepoxybutane

(Goldstein et al., 2001)

gamma ray

(Goldstein et al., 2001)

Progenitor genotype

Cytology

Description

Deletion of about 700bp.

(Hou et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity | somatic clone

(Weber et al., 2000)

lethal (with Df(2R)X1)

(Goldstein et al., 2001)

lethal - all die during embryonic stage | recessive

(Hou et al., 1997)

some die during embryonic stage | recessive

(Hou et al., 1997)

Phenotype Manifest In

embryonic dorsal epidermis

(Hou et al., 1997)

head

(Hou et al., 1997)

ommatidium | somatic clone

(Weber et al., 2000)

photoreceptor cell R3 | somatic clone

(Weber et al., 2000)

photoreceptor cell R4 | somatic clone | increased number

(Weber et al., 2000)

Detailed Description

Statement

Reference

In large clones in the eye many ommatidia display correct polarity though others show chirality flips or symmetry of the R4/R4 cell type. Clusters are occasionally misrotated and photoreceptor cells are occasionally missing, though this phenotype has low penetrance.

(Weber et al., 2000)

Embryos exhibit a dorsal open phenotype (dorsal closure is not initiated) and head defects. Mitotic clones in the eye exhibit wild type ommatidia.

(Hou et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Jra^76-19/Jra[+] is a suppressor | partially of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Weber et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

Jra^76-19 has embryonic dorsal epidermis phenotype, suppressible by Scer\GAL4^pnr-MD237/tkv^{Q199D.UAS.Tag:HA}

(Hou et al., 1997)

Suppressor of

Statement

Reference

Jra^76-19/Jra[+] is a suppressor | partially of ommatidium phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Weber et al., 2000)

Jra^76-19/Jra[+] is a suppressor | partially of photoreceptor cell R4 phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Weber et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^pnr-MD237-mediated expression of tkv^{Q199D.Scer\UAS.T:Ivir\HA1} rescues the dorsal open phenotype.

(Hou et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Jra^76-19 is rescued by Jra^+t5.2

(Hou et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9880

Adh^fn23 pr¹ cn¹ Jra^76-19/CyO

Notes on Origin

Discoverer

Comments

"ethyl methanesulfonate" was stated as tentative. "diepoxybutane" was stated as tentative. "γ ray" was stated as tentative.

(Goldstein et al., 2001)

FlyBase curator comment: The Jra¹ allele, first referred to as 'jun[1]' by Kockel et al., 1997 (FBrf0095439), is NOT the same as Jra^76-19, first referred to as 'Djun[1]' by Hou et al., 1997 (FBrf0095018). The Materials and Methods section of FBrf0095018 states that their 'Djun[1]' was originally named '76-19' by Bour et al, 1995 (FBrf0079902), and this is the superscript used for this allele in FlyBase.

(FlyBase, 1992-)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

76-19

(Goldstein et al., 2001, Hou et al., 1997)

Djun¹

(Hou et al., 1997)

Jra^76-19

(Soory and Ratnaparkhi, 2022)

jra^76-19

(Tesson and Vincent, 2025)

jun^76-19

(Pickup et al., 2002, Weber et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (8)

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