FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\kayC-Ala.UAS
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General Information
Symbol
Dmel\kayC-Ala.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0125004
Feature type
allele
Associated gene
Dmel\kay
Associated Insertion(s)
Carried in Construct
P{UAS-D-fosC-Ala}
Key Links
Transgenic product class
missense_variant
(Ciapponi et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ciapponi et al., 2001)
Mutagen
in vitro construct
(Ciapponi et al., 2001)
Progenitor genotype
Carried in construct
P{UAS-D-fosC-Ala}
Cytology
Description

UASt drives expression of a mutated kay cDNA (carries the amino acid replacements S388A, T449A, T460A, S495A, T542A, T562A and T584A).

(Ciapponi et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
kay
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Over 80% of wing discs with wounds in the posterior compartment show normal wound healing when kayC-Ala.Scer\UAS (a mutant that cannot be phosphorylated by the ERK pathway) is overexpressed under the control of Scer\GAL4en-e16E. However, statistical tests show that this is not significantly different from healing rates in the anterior compartment of the disc, where kayC-Ala.Scer\UAS is not expressed.

      (Bosch et al., 2005)

      kayC-Ala.Scer\UAS when driven by Scer\GAL469B, produces no discernable phenotype in the thorax. When kayC-Ala.Scer\UAS is driven by Scer\GAL4en-e16E a loss-of-vein phenotype is seen in the wing.

      (Ciapponi et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      kayC-Ala.Scer\UAS
      kayC-Ala.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)