FlyBase Allele Report: Dmel\ATP6AP2[5-HA-1890]

General Information

Symbol

Dmel\ATP6AP2^5-HA-1890

Species

D. melanogaster

Name

FlyBase ID

FBal0222046

Feature type

allele

Associated gene

Dmel\ATP6AP2

Associated Insertion(s)

P{RS5}ATP6AP2^5-HA-1890

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{RS5}ATP6AP2^5-HA-1890

Cytology

Description

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:9,260,644..9,260,644 [-]

(Buechling et al., 2010, FlyBase Curators, 2008-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 15

modeled by Ubqn¹

(Şentürk et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of first instar larval stage

(Buechling et al., 2010)

some die during first instar larval stage

(Buechling et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

ATP6AP2^5-HA-1890 heterozygotes are viable.

(Şentürk et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ATP6AP2^5-HA-1890/ATP6AP2[+] is a suppressor | partially of increased mortality during development phenotype of Ubqn¹

(Şentürk et al., 2019)

ATP6AP2^5-HA-1890 is a suppressor | partially of abnormal planar polarity phenotype of Scer\GAL4^dpp.PS, fz^UAS.cAa

(Buechling et al., 2010)

Other

Statement

Reference

ATP6AP2^5-HA-1890/ATP6AP2[+], Ubqn¹ has lethal - all die before end of P-stage phenotype

(Şentürk et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

ATP6AP2^5-HA-1890/ATP6AP2[+] is a suppressor | partially of embryonic/larval fat body | somatic clone | third instar larval stage phenotype of Ubqn¹

(Şentürk et al., 2019)

ATP6AP2^5-HA-1890/ATP6AP2[+] is a suppressor | partially of lysosome | somatic clone | third instar larval stage phenotype of Ubqn¹

(Şentürk et al., 2019)

ATP6AP2^5-HA-1890 is a suppressor | partially of wing hair phenotype of Scer\GAL4^dpp.PS, fz^UAS.cAa

(Buechling et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Ubqn¹ clones in the third instar larval fat body show a severely decreased Lysotracker staining (marker of acidic lysosomes) which is significantly suppressed by ATP6AP2^5-HA-1890 heterozygosity.

(Şentürk et al., 2019)

The planar polarity defects in the wing caused by expression of fz^Scer\UAS.cAa under the control of Scer\GAL4^dpp.PS are partially suppressed by VhaM8.9^5-HA-1890.

(Buechling et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

ATP6AP2^5-HA-1890

CG8444^5-HA-1890

VhaM8.9^5-HA-1890

dPRR-1890P

(Buechling et al., 2010)

vhaM8.9^5-HA-1890

(Şentürk et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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