axon & dorsal cluster neuron | somatic clone
bsk2 heterozygosity suppresses the increased mitotic index in the adult midgut epithelium induced by the adulthood-only expression of UvragHMS01357 under the control of Scer\GAL4esg-NP5130 (and Gal80[ts], for the temporal control of expression).
A bsk2 heterozygous mutant background suppresses the actin remodelling and subsequent basolateral invasion of epithelial cells seen in flies expressing CskGD9345 in a stripe of cells at the anterior/posterior boundary of the larval wing disc under the control of Scer\GAL4ptc-559.1.
The cell invasion phenotype seen when Sin3AKK100700 is strongly expressed (using a line in which the transgene has been mobilised to the third chromosome) under the control of Scer\GAL4ptc-559.1 is suppressed in a bsk2/+ background.
Homozygous bsk2 border follicle cell clones that are also expressing PvrDN.Scer\UAS under the control of Scer\GAL4slbo.2.6 show defects in migration that are more severe than border follicle cells expressing PvrDN.Scer\UAS under the control of Scer\GAL4slbo.2.6 in an otherwise wild-type background.
bsk2 does not protect Df(1)su(s)R194/+ clones in the eye; Df(1)su(s)R194/+ ; bsk2 clones are not recovered in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals). Also, the proportion of Df(1)su(s)R194/+ cells in the larval eye disc is not increased by the presence of bsk2.
bsk2 suppresses the ommatidial polarity defects seen in dshhs.sev.B flies grown at 29oC. About 85% of ommatidia are in their correct polarity compared to 55% in dshhs.sev.B flies alone. Dominantly suppresses the ommatidial polarity phenotype seen in flies with msnEP549 driven by Scer\GAL4hs.2sev, producing near wild-type ommatidial arrays.