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General Information
Symbol
Dmel\SarmΔARM.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0327550
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Ect4 with deletion (aa697-812) of the ARM domain. Tagged with Tag:MYC.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Somatic neural clones expressing Ect4ΔARM.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4VGlut-OK371 undergo spontaneous cell body and axon degeneration. Similarly, expression of Ect4ΔARM.Scer\UAS.T:Hsap\MYC (with the Scer\GAL4ppk.PG driver) leads to neurodegeneration and loss of the multidendritic ddaC neurons in third instar larvae as well as Pdf-positive neurons (under the Scer\GAL4P2.4.Pdf driver combined with tub-Gal80[ts] to restrict the time of expression until adulthood) in adult flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Statement
Reference
NOT Suppressor of
Other
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
NOT Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Ect4896 mutant MARCM clones in sensory neurons in the adult wing expressing Ect4ΔARM.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4VGlut-OK371 undergo spontaneous cell body and axon degeneration, as do clones expressing Ect4ΔARM.Scer\UAS.T:Hsap\MYC alone (using either the Scer\GAL4VGlut-OK371 or the Scer\GAL4nSyb.PS driver). The axon degeneration in these clones can be suppressed by combination with axed2094, axed0011 or Df(3L)BSC411 but not by combination with hiwΔN or any of the following: Cul1k01207, Cul3gft2, Cul306430, Cul3EY11031, Cul411L, Cul4KG02900, Df(3R)Exel6211, Df(3R)3450, Df(3L)BSC413, Df(3L)ED4486, Uba1s3484, Uba1LL03617, Df(1)G1, Roc1bdc3, Df(3L)BSC247, Nedd8KG03071, bsk2, Df(2L)flp170B, Mkk4e01485, Df(3R)Exel6149 or hepr75.

The NmnatΔ4790-1,axed0011 as well as NmnatΔ4790-1,axed2094 double mutant clones display defective injury-induced axon degeneration (severed axons remain intact following an axotomy, instead of being cleared away) which cannot be overcome by expressing Ect4ΔARM.Scer\UAS.T:Hsap\MYC under the Scer\GAL4VGlut-OK371 driver in the mutant clones.

Xenogenetic Interactions
Statement
Reference

The loss of multidendritic ddaC neurons in third instar larvae induced by Ect4ΔARM.Scer\UAS.T:Hsap\MYC expression (with the Scer\GAL4ppk.PG driver) in third instar larvae as well as neurite degeneration in Pdf-positive neurons in adult flies (under the Scer\GAL4P2.4.Pdf driver combined with tub-Gal80[ts] to restrict the expression to adulthood) cannot be rescued by co-expression of BacA\p35Scer\UAS.cHa and can be only partially improved by co-expression of Mmus\WldS.Scer\UAS.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Ect4ΔARM.Scer\UAS.T:Hsap\MYC
Ect4ΔARM.UAS.Tag:MYC
SarmΔARM.UAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (1)