FB2026_02 , released June 18, 2026
Allele: Mmus\WldS.UAS
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General Information
Symbol
Mmus\WldS.UAS
Species
M. musculus
Name
FlyBase ID
FBal0258015
Feature type
allele
Associated gene
Mmus\Wld
Associated Insertion(s)
Carried in Construct
P{UAS-Wld.S}
Also Known As
UAS-WLDS, UAS-Wlds, 5xUAS-wldS
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Hoopfer et al., 2006, MacDonald et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Wld.S}
Cytology
Description

UASt regulatory sequences drive expression of the 'Wld[s]' mutant form of Mmus\Wld.

(Hoopfer et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mmus\Wld
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by NmnatJF03337
      (Fang et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Class IV dendritic arborization neurons expressing Mmus\WldS.UAS under the control of Scer\GAL4DcG fail to fragment and clear dendrite following dendrite injury, as compared to controls.

      (Sapar et al., 2018)

      Expression of 5 copies of Mmus\wldS.Scer\UAS under the control of Scer\GAL4VGlut-OK371 has a strong protective effect on L1 vein neurons following axotomy. Whereas wild type axons undergo fragmentation, many severed but intact axons are observed.

      (Neukomm et al., 2014)

      Expression of Mmus\wldS.Scer\UAS under the control of Scer\GAL4Or22a.7.717 suppresses Wallerian degeneration of axotomized olfactory receptor neuron axons.

      (Kitay et al., 2013)

      Expression of Mmus\wldS.Scer\UAS in olfactory receptor neurons under the control of Scer\GAL4peb-GAL4 blocks signaling from severed axons resulting in severed axons not being cleared from the nervous system and remaining intact after several days. No plasticity is induced in Mmus\wldS.Scer\UAS-expressing flies.

      (Kazama et al., 2011)

      Expression of Mmus\wldS.Scer\UAS in ddaC neurons under the control of Scer\GAL4ppk.1.9 can dramatically delay dendrite degeneration after injury. Dendrites are still present 18 hours after severing, compared to the complete clearance of dendritic debris in controls.

      Pruning of ddaC dendrites is delayed upon expression of Mmus\wldS.Scer\UAS under the control of Scer\GAL4ppk.1.9.

      (Tao and Rolls, 2011)

      Expression of Mmus\wldS.Scer\UAS in the ddaC neurons (using the Scer\GAL4ppk.PG line) delays removal of ddaC dendritic branches at 18 hours after puparium formation.

      (Schoenmann et al., 2010)

      Expression of Mmus\wldS.Scer\UAS under the control of Scer\GAL4Or22a.8197 has a protective effect on olfactory receptor neurons following axotomy: 77% of olfactory receptor neuron axons remain intact 30 days after injury.

      (Avery et al., 2009)

      Expression of Mmus\wldS.Scer\UAS in antennal ORNs using Scer\GAL4Or22a.8197 can protect severed axons from Wallerian degeneration for weeks, with Mmus\wldS.Scer\UAS expressing exons exhibiting largely normal morphology. By 50 days after injury, the axons of Mmus\wldS.Scer\UAS-expressing neurons have degenerated significantly, with approximately 20% of antennal lobes containing detectable axon fibers. All severed axons ultimately degenerate between 30 and 50 days after injury.

      (MacDonald et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      Mmus\WldS.UAS, Scer\GAL4Or22a.8197 has abnormal neuroanatomy | conditional phenotype, non-suppressible by Sirt1NIG.5216R, Scer\GAL4Or22a.8197

      (Avery et al., 2009)

      Mmus\WldS.UAS, Scer\GAL4Or22a.8197 has abnormal neuroanatomy | conditional phenotype, non-suppressible by Sirt14.5/Sirt15.26

      (Avery et al., 2009)
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The loss of multidendritic ddaC neurons in third instar larvae induced by Ect4ΔARM.Scer\UAS.T:Hsap\MYC expression (with the Scer\GAL4ppk.PG driver) in third instar larvae as well as neurite degeneration in Pdf-positive neurons in adult flies (under the Scer\GAL4P2.4.Pdf driver combined with tub-Gal80[ts] to restrict the expression to adulthood) can be partially improved by co-expression of Mmus\WldS.Scer\UAS.

      (Neukomm et al., 2017)

      The loss of olfactory receptor neuron (ORN) cell bodies and axons and the morphological defects in the antennal lobe neuropil which are seen when homozygous milt33-853 ORN clones are induced is not suppressed by expression of Mmus\wldS.Scer\UAS under the control of Scer\GAL4Or22a.7.717.

      Expression of Mmus\wldS.Scer\UAS under the control of Scer\GAL4elav-C155 protects both wild-type and milt33-853 motor neuron clones from degeneration after axotomy at 16 hours after crushing and delays Wallerian degeneration in both wild-type and milt33-853 motor neuron clones 24 hours after crushing.

      (Kitay et al., 2013)

      Co-expression of Mmus\wldS.Scer\UAS and BacA\p35Scer\UAS.cHa in ddaC neurons (under the control of Scer\GAL4ppk.PG) results in significantly better protection of dendrites than flies expressing either transgene alone.

      (Schoenmann et al., 2010)

      Co-expression of TER94GD9777 suppresses the protective effect on axotomised olfactory receptor neurons in flies expressing Mmus\wldS.Scer\UAS under the control of Scer\GAL4Or22a.8197. An increased amount of Wallerian degeneration is seen 15 days after injury. No effect is seen in uninjured age-matched controls.

      Co-expression of Sir2NIG.5216R does not suppress the protective effect on axotomised olfactory receptor neurons in flies expressing Mmus\wldS.Scer\UAS under the control of Scer\GAL4Or22a.8197. No change is seen in the amount of Wallerian degeneration 15 days after injury.

      Sir24.5/Sir25.26 does not suppress the protective effect on axotomised olfactory receptor neurons in flies expressing Mmus\wldS.Scer\UAS under the control of Scer\GAL4Or22a.8197. No change is seen in the amount of Wallerian degeneration 15 days after injury.

      (Avery et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Mmus\WldS.Scer\UAS
      Mmus\WldS.UAS
      Mmus\wldS.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (23)