FlyBase Allele Report: Dmel\Sirt1[5.26]

General Information

Symbol

Dmel\Sirt1^5.26

Species

D. melanogaster

Name

FlyBase ID

FBal0141416

Feature type

allele

Associated gene

Dmel\Sirt1

Associated Insertion(s)

Carried in Construct

Also Known As

sir2^5.26, dSir2^5.26

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

P{PZ}Sirt1^05327a

(Newman et al., 2002)

Cytology

Description

Imprecise excision of the P{lacW} element, resulting in a deletion of Sirt1 sequences from -16 to +859 (coding sequences of the adjacent gene, DnaJ-H, are intact).

(Newman et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:13,165,535..13,166,410 [+]

Comment:

A deletion resulting from the imprecise excision of P{PZ}Sirt1^05327a, removes sequences from -16 to +859 with respect to the Sirt1 transcription start. The start site was mapped to a base that corresponds to the 5' end of EST GB:LD07439.

(Newman et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile (with Sirt1^4.5)

(Newman et al., 2002)

suppressor of variegation (with Sirt1^4.5), with In(1)w^m4

(Newman et al., 2002)

viable (with Sirt1^4.5)

(Newman et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

Sir2^4.5/Sir2^5.26 males and females have normal lifespans.

(Balan et al., 2008)

Unlike wild-type flies, the lifespan of Sirt1^4.5/Sirt1^5.26 flies is not extended by a diet of low-calorie food.

(Rogina and Helfand, 2004)

Sir2^4.5/Sir2^5.26 flies are phenotypically normal. Under nonstress environmental conditions, the average median life span of Sir2^4.5/Sir2^5.26 males is slightly, but significantly less than that of heterozygous controls. The average life span is not significantly different from controls. Under stress conditions, the mean life span of Sir2^4.5/Sir2^5.26 males is not significantly different from controls. The median life span of Sir2^4.5/Sir2^5.26 males is significantly longer than that of controls.

(Newman et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Sirt1^4.5/Sirt1^5.26 is a suppressor of long lived phenotype of Naam^UAS.Tag:V5, Scer\GAL4^Tub.PU

(Balan et al., 2008)

NOT Suppressor of

Statement

Reference

Sirt1^4.5/Sirt1^5.26 is a non-suppressor of abnormal neuroanatomy | conditional phenotype of Mmus\Wld^S.UAS, Scer\GAL4^Or22a.8197

(Avery et al., 2009)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Sirt1^4.5/Sirt1^5.26 is a non-suppressor of olfactory receptor neuron | conditional phenotype of Mmus\Wld^S.UAS, Scer\GAL4^Or22a.8197

(Avery et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The increase in lifespan caused by expression of Naam^{Scer\UAS.T:SV5\V5} under the control of Scer\GAL4^elav.PLu is completely suppressed by Sir2^4.5/Sir2^5.26.

(Balan et al., 2008)

Xenogenetic Interactions

Statement

Reference

Sir2^4.5/Sir2^5.26 does not suppress the protective effect on axotomised olfactory receptor neurons in flies expressing Mmus\wld^S.Scer\UAS under the control of Scer\GAL4^Or22a.8197. No change is seen in the amount of Wallerian degeneration 15 days after injury.

(Avery et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

32657

Sirt1^5.26 cn¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Sir2^5.26

(Qu et al., 2025, Avery et al., 2009, Balan et al., 2008, Wood et al., 2004)

Sirt1^5.26

dSir2^5.26

(Rogina and Helfand, 2004, Newman et al., 2002)

l(2)05327^5.26

(Newman et al., 2002)

sir2^5.26

(Avery et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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