FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Mmus\Wld
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General Information
Symbol
Mmus\Wld
Species
M. musculus
Name
wallerian degeneration
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0263101
Gene Model Status
Not Applicable
Stock Availability
None publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Wld

Key Links
Foreign Gene Data

Foreign sequence; species == Mus musculus; gene == Wld; MGI:MGI:98952.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mmus\Wld
Transgenic constructs containing regulatory region of Mmus\Wld
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Other Phenotypes
Allele
abnormal neuroanatomy, with Scer\GAL4Or22a.8197
abnormal neuroanatomy, with Scer\GAL4peb-GAL4
abnormal neuroanatomy, with Scer\GAL4ppk.1.9
abnormal neuroanatomy | cell autonomous, with Scer\GAL4Or22a.8197
abnormal neuroanatomy | conditional, with Scer\GAL4Or22a.8197
abnormal neuroanatomy | conditional, with Scer\GAL4VGlut1-OK371
abnormal neuroanatomy | larval stage, with Scer\GAL4ppk.PH
abnormal stress response | adult stage, with Scer\GAL4elav-C155
abnormal stress response | larval stage, with Scer\GAL4ppk.PH
abnormal touch response | adult stage, with Scer\GAL4elav-C155
Phenotype manifest in
Allele
adult olfactory receptor neuron | cell autonomous, with Scer\GAL4Or22a.8197
axon | adult stage, with Scer\GAL4elav-C155
dendrite, with Scer\GAL4ppk.1.9
dendrite, with Scer\GAL4ppk.PG
dendrite | conditional, with Scer\GAL4DcG
dendrite | larval stage, with Scer\GAL4ppk.PH
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.PG
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.PH
larval multidendritic class IV neuron | larval stage | conditional, with Scer\GAL4DcG
olfactory receptor neuron, with Scer\GAL4Or22a.8197
olfactory receptor neuron | conditional, with Scer\GAL4Or22a.8197
wing nerve, with Scer\GAL4elav-C155
wing vein L1 | conditional, with Scer\GAL4VGlut1-OK371
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (0)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Mmus\WldS.UAS
ameliorates  neurodegenerative disease
modeled by NmnatJF03337
(Fang et al., 2012)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
Summary of Genetic Interactions
Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
Class of Gene
Stocks and Reagents
Stocks (0)
Other Comments

Transected Drosophila axons undergo injury-induced degeneration that is morphologically similar to Wallerian degeneration in mammals and can be suppressed by the neuro-protective properties of Mmus\wld.

(MacDonald et al., 2006)

Mmus\wld is a fusion gene formed from Mmus\Ube4b and Mmus\Nmnat1.

(FlyBase Curators, 1992-)
Relationship to Other Genes
Source for database merge of
Additional comments
Nomenclature History
Source for database identify of
Nomenclature comments
Etymology
Synonyms and Secondary IDs (5)
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
Study result (0)
Result
Result Type
Title
External Crossreferences and Linkouts ( 1 )
Other crossreferences
Mouse Genome Database - The international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease.
References (30)