FlyBase Allele Report: Dmel\Sirt1[NIG.5216R]

General Information

Symbol

Dmel\Sirt1^NIG.5216R

Species

D. melanogaster

Name

FlyBase ID

FBal0274580

Feature type

allele

Associated gene

Dmel\Sirt1

Associated Insertion(s)

Carried in Construct

P{NIG.5216R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21)

Progenitor genotype

Carried in construct

P{NIG.5216R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-5216R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Olfactory receptor neuron axons expressing Sir2^NIG.5216R under the control of Scer\GAL4^Or22a.8197 appear normal 15 days after injury.

(Avery et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Sirt1^NIG.5216R, Scer\GAL4^Or22a.8197 is a non-suppressor of abnormal neuroanatomy | conditional phenotype of Mmus\Wld^S.UAS, Scer\GAL4^Or22a.8197

(Avery et al., 2009)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Sirt1^NIG.5216R, Scer\GAL4^Or22a.8197 is a non-suppressor of olfactory receptor neuron | conditional phenotype of Mmus\Wld^S.UAS, Scer\GAL4^Or22a.8197

(Avery et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Sir2^NIG.5216R does not suppress the protective effect on axotomised olfactory receptor neurons in flies expressing Mmus\wld^S.Scer\UAS under the control of Scer\GAL4^Or22a.8197. No change is seen in the amount of Wallerian degeneration 15 days after injury.

(Avery et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

NIG-Fly

5216R-1

P{NIG.5216R}1

5216R-2

P{NIG.5216R}2