FlyBase Allele Report: Dmel\Cul4[11L]

General Information

Symbol

Dmel\Cul4^11L

Species

D. melanogaster

Name

FlyBase ID

FBal0220979

Feature type

allele

Associated gene

Dmel\Cul4

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Hu et al., 2008)

Progenitor genotype

Cul4^EP2518

(Hu et al., 2008)

Cytology

Description

Imprecise excision of the insertion in cul-4^EP2518.

(Hu et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2R)ED1735)

(Kahsai et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

Cul4^11L mutant clones in sensory neurons in adult wing do not display any defects in injury-induced axon degeneration (following an axotomy, the severed axons are cleared away normally).

(Neukomm et al., 2017)

Homozygous larvae arrest in the first instar, with the larvae capable of surviving for more than 10 days on rich medium without growing.

(Hu et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cul4[+]/Cul4^11L is a suppressor | partially of abnormal neurophysiology | larval stage phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

NOT Suppressor of

Statement

Reference

Cul4^11L is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut1-OK371

(Neukomm et al., 2017)

Other

Statement

Reference

Cul4^11L, GluRIIA^SP16 has abnormal neurophysiology phenotype

(Patrón et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cul4^11L is a suppressor of NMJ bouton | increased number | larval stage phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

Cul4^11L is a suppressor | partially of larval somatic muscle phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

Cul4[+]/Cul4^11L is a suppressor | partially of embryonic/larval neuromuscular junction phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

NOT Suppressor of

Statement

Reference

Cul4^11L is a non-suppressor of nucleus | larval stage phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

Cul4^11L is a non-suppressor of larval muscle cell phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

Cul4^11L is a non-suppressor of sensory neuron | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut1-OK371

(Neukomm et al., 2017)

Cul4^11L is a non-suppressor of axon | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut1-OK371

(Neukomm et al., 2017)

Other

Statement

Reference

Cul4^11L, GluRIIA^SP16 has neuromuscular junction phenotype

(Patrón et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

The axon degeneration in sensory neurons clones in the adult wing expressing Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^VGlut-OK371 can be suppressed by combination with Cul4^11L.

(Neukomm et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

34053

y¹ w^*; P{FRT(w^hs)}G13 Cul4^11L/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Cul-4^11L

Cul4^11L

(Hu et al., 2008)

cul-4^11L

cul4^11L

(Patrón et al., 2019, Neukomm et al., 2017, Wong et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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