FlyBase Allele Report: Dmel\DCAF12[UAS.cPa]

General Information

Symbol

Dmel\DCAF12^UAS.cPa

Species

D. melanogaster

Name

UAS construct a of Patron

FlyBase ID

FBal0408389

Feature type

allele

Associated gene

Dmel\DCAF12

Associated Insertion(s)

Carried in Construct

P{UAS-DCAF12.P}

Key Links

Transgenic product class

cDNA

(Patrón et al., 2019)

wild_type

(Patrón et al., 2019)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Patrón et al., 2019)

wild_type

(Patrón et al., 2019)

Mutagen

in vitro construct

(Patrón et al., 2019)

Progenitor genotype

Carried in construct

P{UAS-DCAF12.P}

Cytology

Description

UASt regulatory sequences drive expression of full-length DCAF12 (amplified from the LD21841 cDNA clone).

(Patrón et al., 2019)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

DCAF12

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | larval stage, with Scer\GAL4^C57

(Patrón et al., 2019)

abnormal size | larval stage, with Scer\GAL4^C57

(Patrón et al., 2019)

Phenotype Manifest In

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^C57

(Patrón et al., 2019)

larval muscle cell, with Scer\GAL4^C57

(Patrón et al., 2019)

larval somatic muscle, with Scer\GAL4^C57

(Patrón et al., 2019)

NMJ bouton | increased number | larval stage, with Scer\GAL4^C57

(Patrón et al., 2019)

nucleus | larval stage, with Scer\GAL4^C57

(Patrón et al., 2019)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

DCAF12^UAS.cPa, Scer\GAL4^C57 has abnormal size | larval stage phenotype, non-enhanceable by pic^EY01408

(Patrón et al., 2019)

Suppressed by

Statement

Reference

DCAF12^UAS.cPa, Scer\GAL4^C57 has abnormal neurophysiology | larval stage phenotype, suppressible | partially by Cul4[+]/Cul4^11L

(Patrón et al., 2019)

NOT suppressed by

Statement

Reference

DCAF12^UAS.cPa, Scer\GAL4^C57 has abnormal size | larval stage phenotype, non-suppressible by pic^EY01408

(Patrón et al., 2019)

Other

Statement

Reference

DCAF12^Δ51, DCAF12^UAS.cPa, GluRIIA^SP16, Scer\GAL4^nSyb.PU has abnormal neurophysiology phenotype

(Patrón et al., 2019)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

DCAF12^UAS.cPa, Scer\GAL4^C57 has NMJ bouton | larval stage | increased number phenotype, non-enhanceable by pic^EY01408

(Patrón et al., 2019)

DCAF12^UAS.cPa, Scer\GAL4^C57 has larval somatic muscle phenotype, non-enhanceable by pic^EY01408

(Patrón et al., 2019)

Suppressed by

Statement

Reference

DCAF12^UAS.cPa, Scer\GAL4^C57 has NMJ bouton | increased number | larval stage phenotype, suppressible by Cul4^11L

(Patrón et al., 2019)

DCAF12^UAS.cPa, Scer\GAL4^C57 has larval somatic muscle phenotype, suppressible | partially by Cul4^11L

(Patrón et al., 2019)

DCAF12^UAS.cPa, Scer\GAL4^C57 has embryonic/larval neuromuscular junction phenotype, suppressible | partially by Cul4[+]/Cul4^11L

(Patrón et al., 2019)

NOT suppressed by

Statement

Reference

DCAF12^UAS.cPa, Scer\GAL4^C57 has nucleus | larval stage phenotype, non-suppressible by Cul4^11L

(Patrón et al., 2019)

DCAF12^UAS.cPa, Scer\GAL4^C57 has NMJ bouton | increased number | larval stage phenotype, non-suppressible by pic^EY01408

(Patrón et al., 2019)

DCAF12^UAS.cPa, Scer\GAL4^C57 has larval somatic muscle phenotype, non-suppressible by pic^EY01408

(Patrón et al., 2019)

DCAF12^UAS.cPa, Scer\GAL4^C57 has larval muscle cell phenotype, non-suppressible by Cul4^11L

(Patrón et al., 2019)

Other

Statement

Reference

DCAF12^Δ51, DCAF12^UAS.cPa, GluRIIA^SP16, Scer\GAL4^nSyb.PU has neuromuscular junction phenotype

(Patrón et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^nSyb.PU/DCAF12^UAS.cPa rescues DCAF12^Δ51

(Patrón et al., 2019)

Fails to rescue

DCAF12^UAS.cPa/Scer\GAL4^C57 fails to rescue DCAF12^Δ51

(Patrón et al., 2019)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

DCAF12^UAS.cPa

Name Synonyms

UAS construct a of Patron

Secondary FlyBase IDs

References (1)

Report Sections

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