FlyBase Allele Report: Dmel\pic[EY01408]

General Information

Symbol

Dmel\pic^EY01408

Species

D. melanogaster

Name

FlyBase ID

FBal0148088

Feature type

allele

Associated gene

Dmel\pic

Associated Insertion(s)

P{EPgy2}pic^EY01408

Carried in Construct

Also Known As

EY01408

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}pic^EY01408

Cytology

Description

Insertion in the 5' untranslated region.

(Hu et al., 2008)

Insertion in the 5' exon of DDB1.

(Takata et al., 2004)

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:13,052,363..13,052,363 [-]

(Lee et al., 2010, Lin et al., 2009, Hu et al., 2008, Takata et al., 2004, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH, pic^RNAi.650.UAS

(Takata et al., 2004)

melanotic mass

(Takata et al., 2004)

Detailed Description

Statement

Reference

Larvae homozygous for pic^EY01408 survive till second instar larval stage.

(Lin et al., 2009)

Most homozygous animals die at the first larval instar, due to melanotic tumours. The small eye phenotype caused by expression of one copy of DDB1^{dsRNA.650.Scer\UAS} under the control of one copy of Scer\GAL4^ey.PH is more severe if the flies are also carrying DDB1^EY01408.

(Takata et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

pic^EY01408 is a non-enhancer of abnormal size | larval stage phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

NOT Suppressor of

Statement

Reference

pic^EY01408 is a non-suppressor of abnormal size | larval stage phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

pic^EY01408 is a non-enhancer of NMJ bouton | larval stage | increased number phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

pic^EY01408 is a non-enhancer of larval somatic muscle phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

NOT Suppressor of

Statement

Reference

pic^EY01408 is a non-suppressor of NMJ bouton | increased number | larval stage phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

pic^EY01408 is a non-suppressor of larval somatic muscle phenotype of DCAF12^UAS.cPa, Scer\GAL4^C57

(Patrón et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

15350

y¹ w^67c23; P{EPgy2}pic^EY01408/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

Comments

Excision of the insertion can revert the lethal phenotype.

(Takata et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

DDB1^EY01408

pic^EY01408

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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