FlyBase Allele Report: Dmel\Rac1[GMR.PN]

General Information

Symbol

Dmel\Rac1^GMR.PN

Species

D. melanogaster

Name

glass multimer reporter construct of Nolan

FlyBase ID

FBal0094009

Feature type

allele

Associated gene

Dmel\Rac1

Associated Insertion(s)

Carried in Construct

P{GMR-Rac1.N}

Also Known As

GMR-dRac1, GMR-Rac1

Key Links

Transgenic product class

wild_type

(Nolan et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Nolan et al., 1998)

Mutagen

in vitro construct

(Nolan et al., 1998)

Progenitor genotype

Carried in construct

P{GMR-Rac1.N}

Cytology

Description

Full length coding region is expressed under the control of GMR regulatory sequences.

(Nolan et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Rac1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Stronach and Perrimon, 2002, Raymond et al., 2001, Bateman et al., 2000, Nolan et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

Rac1^GMR.PN flies have a subtle rough eye.

(Neisch et al., 2013)

Rac1^GMR.PN animals display a rough eye phenotype that perturbs mainly the posterior part. This phenotype is not fully penetrant and ~20% of flies exhibit a relatively normal eye.

(Baril et al., 2009)

Rac1^GMR.PN flies display a rough eye phenotype.

(Chen et al., 2005)

Rac1^GMR.PN flies have small, rough eyes.

(Tan et al., 2003)

Flies expressing Rac1^GMR.PN have eyes with a rough, glazed appearance.

(Stronach and Perrimon, 2002)

Flies carrying Rac1^GMR.PN have moderately rough eyes, with flattened but distinct ommatidia. Interommatidial bristles are occasionally missing.

(Raymond et al., 2001)

Rough patterned eye with misshapen, fused and flattened ommatidia.

(Bateman et al., 2000)

Flies bearing one copy of P{GMR-Rac1.N} show a rough eye phenotype. Pigment cells are missing, ommatidial morphology is disrupted and photoreceptor cells are occasionally lost. Two copies of P{GMR-Rac1.N} increase the severity of the phenotype.

(Nolan et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Rac1^GMR.PN has visible phenotype, enhanceable by puc^E69/puc[+]

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has visible phenotype, enhanceable by Df(3R)rn20/+

(Raymond et al., 2001)

NOT Enhanced by

Statement

Reference

Rac1^GMR.PN has visible phenotype, non-enhanceable by Tak1[+]/Tak1²⁵²⁷

(Stronach and Perrimon, 2002)

Suppressed by

Statement

Reference

Rac1^GMR.PN has visible phenotype, suppressible by bsk¹/bsk[+]

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has visible phenotype, suppressible by hep[+]/hep¹

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has visible phenotype, suppressible by slpr[+]/slpr^3P5

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has visible phenotype, suppressible by slpr⁹²¹/slpr[+]

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has visible phenotype, suppressible by msn[+]/msn¹⁰²

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has visible phenotype, suppressible by Df(3L)Ar12-1/+

(Bateman et al., 2000)

Rac1^GMR.PN has visible phenotype, suppressible by trio[+]/trio^2H

(Bateman et al., 2000)

NOT suppressed by

Statement

Reference

Rac1^GMR.PN has visible phenotype, non-suppressible by Tak1[+]/Tak1²⁵²⁷

(Stronach and Perrimon, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

Rac1^GMR.PN has eye phenotype, enhanceable by conu^{UAS.Tag:Myr(Unk),Tag:FLAG}/Scer\GAL4^GMR.PF

(Neisch et al., 2013)

Rac1^GMR.PN has eye phenotype, enhanceable by Arf6^UAS.cCa/Scer\GAL4^GMR.PF

(Neisch et al., 2013)

Rac1^GMR.PN has eye phenotype, enhanceable by puc^A251.1F3/puc[+]

(Baril et al., 2009)

Rac1^GMR.PN has eye phenotype, enhanceable by alph^S-331/alph[+]

(Baril et al., 2009)

Rac1^GMR.PN has eye phenotype, enhanceable by alph^S-331.GMR/alph[+]

(Baril et al., 2009)

Rac1^GMR.PN has eye phenotype, enhanceable by Pax^GMR.PC

(Chen et al., 2005)

Rac1^GMR.PN has eye phenotype, enhanceable by sqh^E20.E21

(Tan et al., 2003)

Rac1^GMR.PN has eye phenotype, enhanceable by Mbs[+]/Mbs⁰³⁸⁰²

(Tan et al., 2003)

Rac1^GMR.PN has eye phenotype, enhanceable by Df(3L)th102

(Tan et al., 2003)

Rac1^GMR.PN has eye phenotype, enhanceable by Mbs^2-188/Mbs[+]

(Tan et al., 2003)

Rac1^GMR.PN has eye phenotype, enhanceable by Mbs^2-199/Mbs[+]

(Tan et al., 2003)

Rac1^GMR.PN has eye phenotype, enhanceable by ck[+]/ck¹³

(Tan et al., 2003)

Rac1^GMR.PN has eye phenotype, enhanceable by puc^E69/puc[+]

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has ommatidium phenotype, enhanceable by puc^E69/puc[+]

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has eye phenotype, enhanceable by Df(3R)rn20/+

(Raymond et al., 2001)

Rac1^GMR.PN has interommatidial bristle phenotype, enhanceable by Df(3R)rn20/+

(Raymond et al., 2001)

Rac1^GMR.PN has ommatidium phenotype, enhanceable by Df(3R)rn20/+

(Raymond et al., 2001)

NOT Enhanced by

Statement

Reference

Rac1^GMR.PN has eye phenotype, non-enhanceable by Tak1[+]/Tak1²⁵²⁷

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has ommatidium phenotype, non-enhanceable by Tak1[+]/Tak1²⁵²⁷

(Stronach and Perrimon, 2002)

Suppressed by

Statement

Reference

Rac1^GMR.PN has eye phenotype, suppressible by alph^GMR

(Baril et al., 2009)

Rac1^GMR.PN has eye phenotype, suppressible by slpr⁹²¹/slpr[+]

(Baril et al., 2009, Stronach and Perrimon, 2002)

Rac1^GMR.PN has eye phenotype, suppressible by bsk¹/bsk[+]

(Baril et al., 2009, Stronach and Perrimon, 2002)

Rac1^GMR.PN has eye phenotype, suppressible by Rho1^72O/Rho1[+]

(Tan et al., 2003)

Rac1^GMR.PN has eye phenotype, suppressible by rok[+]/Rok²

(Tan et al., 2003)

Rac1^GMR.PN has eye phenotype, suppressible by sqh^{A20.A21.Tag:FLAG}

(Tan et al., 2003)

Rac1^GMR.PN has eye phenotype, suppressible by zip[+]/zip¹

(Tan et al., 2003)

Rac1^GMR.PN has eye phenotype, suppressible by msn[+]/msn¹⁰²

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has eye phenotype, suppressible by slpr[+]/slpr^3P5

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has ommatidium phenotype, suppressible by bsk¹/bsk[+]

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has ommatidium phenotype, suppressible by hep[+]/hep¹

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has ommatidium phenotype, suppressible by msn[+]/msn¹⁰²

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has ommatidium phenotype, suppressible by slpr[+]/slpr^3P5

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has ommatidium phenotype, suppressible by slpr⁹²¹/slpr[+]

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has eye phenotype, suppressible by hep[+]/hep¹

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has eye phenotype, suppressible by Df(3L)Ar12-1/+

(Bateman et al., 2000)

Rac1^GMR.PN has eye phenotype, suppressible by trio[+]/trio^2H

(Bateman et al., 2000)

Rac1^GMR.PN has ommatidium phenotype, suppressible by Df(3L)Ar12-1/+

(Bateman et al., 2000)

Rac1^GMR.PN has ommatidium phenotype, suppressible by trio[+]/trio^2H

(Bateman et al., 2000)

Rac1^GMR.PN has eye phenotype, suppressible by mbc^2.35

(Nolan et al., 1998)

Rac1^GMR.PN has ommatidium phenotype, suppressible by mbc^2.35

(Nolan et al., 1998)

Rac1^GMR.PN has photoreceptor phenotype, suppressible by mbc^2.35

(Nolan et al., 1998)

Rac1^GMR.PN has pigment cell phenotype, suppressible by mbc^2.35

(Nolan et al., 1998)

Rac1^GMR.PN has eye phenotype, suppressible by mbc^3.5

(Nolan et al., 1998)

Rac1^GMR.PN has ommatidium phenotype, suppressible by mbc^3.5

(Nolan et al., 1998)

Rac1^GMR.PN has photoreceptor phenotype, suppressible by mbc^3.5

(Nolan et al., 1998)

Rac1^GMR.PN has pigment cell phenotype, suppressible by mbc^3.5

(Nolan et al., 1998)

Rac1^GMR.PN has eye phenotype, suppressible by mbc^1.63

(Nolan et al., 1998)

Rac1^GMR.PN has ommatidium phenotype, suppressible by mbc^1.63

(Nolan et al., 1998)

Rac1^GMR.PN has photoreceptor phenotype, suppressible by mbc^1.63

(Nolan et al., 1998)

Rac1^GMR.PN has pigment cell phenotype, suppressible by mbc^1.63

(Nolan et al., 1998)

Rac1^GMR.PN has eye phenotype, suppressible by mbc^4.25

(Nolan et al., 1998)

Rac1^GMR.PN has ommatidium phenotype, suppressible by mbc^4.25

(Nolan et al., 1998)

Rac1^GMR.PN has photoreceptor phenotype, suppressible by mbc^4.25

(Nolan et al., 1998)

Rac1^GMR.PN has pigment cell phenotype, suppressible by mbc^4.25

(Nolan et al., 1998)

NOT suppressed by

Statement

Reference

Rac1^GMR.PN has eye phenotype, non-suppressible by Tak1[+]/Tak1²⁵²⁷

(Stronach and Perrimon, 2002)

Rac1^GMR.PN has ommatidium phenotype, non-suppressible by Tak1[+]/Tak1²⁵²⁷

(Stronach and Perrimon, 2002)

Other

Statement

Reference

Rac1^GMR.PN, Scer\GAL4^GMR.PF, conu^{GAP.UAS.Tag:Myr(Unk),Tag:FLAG} has eye phenotype

(Neisch et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^GMR.PF-mediated expression of conu^{Scer\UAS.T:Uuuu\Myr5,T:Zzzz\FLAG} or conu^{R402A.Scer\UAS.T:Uuuu\Myr5,T:Zzzz\FLAG} mildly enhances the rough eye of Rac1^GMR.PN flies.

Scer\GAL4^GMR.PF-mediated expression of conu^{GAP.Scer\UAS.T:Uuuu\Myr5,T:Zzzz\FLAG} in a Rac1^GMR.PN background results in a phenotype similar, but not quite identical to that of Scer\GAL4^GMR.PF conu^{GAP.Scer\UAS.T:Uuuu\Myr5,T:Zzzz\FLAG} flies alone.

Scer\GAL4^GMR.PF-mediated expression of Arf51F^Scer\UAS.cCa strongly enhances the rough eye of Rac1^GMR.PN flies.

(Neisch et al., 2013)

Co-expression of alph^S-331.GMR is not only unable to suppress the Rac1^GMR.PN rough eye, but also slightly enhances this phenotype.

(Baril et al., 2009)

The rough-eye phenotype of Rac1^GMR.PN flies is much enhanced when Pax^GMR.PC is co-expressed.

(Chen et al., 2005)

The small, rough eye phenotype of Rac1^GMR.PN flies is enhanced by heterozygosity for Mbs⁰³⁸⁰², Mbs^2-188, Mbs^2-199, sqh^E20.E21 or ck¹³. This phenotype is more severely enhanced by heterozygosity for Df(3L)th102. The small, rough eye phenotype of Rac1^GMR.PN flies is partially suppressed by heterozygosity for Rho1^72O, rok², zip¹, or sqh^{A20.A21.T:Zzzz\FLAG}.

(Tan et al., 2003)

Flies carrying Rac1^GMR.PN in a Df(3R)rn20/+ background have severely reduced, very smooth eyes with fused ommatidia and almost total loss of bristles.

(Raymond et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rac1^GMR.PN

Name Synonyms

glass multimer reporter construct of Nolan

(Nolan et al., 1998)

Secondary FlyBase IDs

References (8)

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