FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tak12527
Open Close
General Information
Symbol
Dmel\Tak12527
Species
D. melanogaster
Name
FlyBase ID
FBal0134137
Feature type
allele
Associated gene
Dmel\Tak1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Polaski et al., 2006)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: W178term.

    (Polaski et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:20,522,654..20,522,654 [-]
    Nucleotide change:

    G20522654A

    Amino acid change:

    W179term | Tak1-PA

    Reported amino acid change:

    W178term

    Comment:

    G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Polaski et al., 2006)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Tak12527 mutants show increased mortality as a result of WNV-Kun infection when compared to controls.

        (Ahlers et al., 2019)

        Homozygous flies are more sensitive to Cricket Paralysis virus infection (after being injected with the virus) than control flies.

        (Costa et al., 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        Tak1[+]/Tak12527 is an enhancer of partially lethal - majority die phenotype of slprBS06

        (Polaski et al., 2006)
        NOT Enhancer of
        Statement
        Reference

        Tak1[+]/Tak12527 is a non-enhancer of visible | adult stage phenotype of HPV18\E6UAS.Tag:MYC, Hsap\UBE3AUAS.cRa, Scer\GAL4GMR.PU

        (Padash Barmchi et al., 2016)

        Tak1[+]/Tak12527 is a non-enhancer of visible phenotype of Rac1GMR.PN

        (Stronach and Perrimon, 2002)
        NOT Suppressor of
        Statement
        Reference

        Tak1[+]/Tak12527 is a non-suppressor of visible phenotype of Rac1GMR.PN

        (Stronach and Perrimon, 2002)
        Phenotype Manifest In
        NOT Enhancer of
        Statement
        Reference

        Tak1[+]/Tak12527 is a non-enhancer of eye phenotype of HPV18\E6UAS.Tag:MYC, Hsap\UBE3AUAS.cRa, Scer\GAL4GMR.PU

        (Padash Barmchi et al., 2016)

        Tak1[+]/Tak12527 is a non-enhancer of eye phenotype of Rac1GMR.PN

        (Stronach and Perrimon, 2002)

        Tak1[+]/Tak12527 is a non-enhancer of ommatidium phenotype of Rac1GMR.PN

        (Stronach and Perrimon, 2002)
        NOT Suppressor of
        Statement
        Reference

        Tak12527 is a non-suppressor of eye disc | somatic clone | larval stage phenotype of BacA\p35UAS.cUa, Scer\GAL4Act.PU, hidUAS.cUa

        (Farrell et al., 2022)

        Tak12527 is a non-suppressor of filamentous actin | somatic clone | larval stage phenotype of BacA\p35UAS.cUa, Scer\GAL4Act.PU, hidUAS.cUa

        (Farrell et al., 2022)

        Tak1[+]/Tak12527 is a non-suppressor of eye phenotype of Rac1GMR.PN

        (Stronach and Perrimon, 2002)

        Tak1[+]/Tak12527 is a non-suppressor of ommatidium phenotype of Rac1GMR.PN

        (Stronach and Perrimon, 2002)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The weak lethal phenotype seen in slprBS06/Y mutants is enhanced by Tak12527/+, such that no double mutant adults eclose and there is a slight increase in the relative embryonic lethality and dorsal closure defects of double mutant embryos.

        (Polaski et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference

        Heterozygosity for Tak12527 does not modify the fully penetrant rough eye phenotype resulting from the co-expression of HPV18\E6Scer\UAS.T:Hsap\MYC and Hsap\UBE3AScer\UAS.cRa under the control of Scer\GAL4GMR.PU, leading to severe eye necrosis.

        (Padash Barmchi et al., 2016)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        TAK12527
        (Farrell et al., 2022)
        Tak12527
        (Padash Barmchi et al., 2016, Lesch et al., 2010, Costa et al., 2009, Polaski et al., 2006)
        dTAK2527
        (Stronach and Perrimon, 2002)
        tak12527
        (Ahlers et al., 2019)
        Name Synonyms
        Secondary FlyBase IDs
          References (8)