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General Information
Symbol
Dmel\slpr3P5
Species
D. melanogaster
Name
FlyBase ID
FBal0134001
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:

    G8175085A

    Reported nucleotide change:

    G?A

    Amino acid change:

    W361term | slpr-PA; W361term | slpr-PB; W361term | slpr-PC; W361term | slpr-PD

    Reported amino acid change:

    W?term

    Comment:

    TGG to TGA nonsense mutation in Trp codon.

    Comment:

    TGG to TGA nonsense mutation in Trp codon

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Nucleotide substitution: G?A.

    Amino acid replacement: W360term.

    Mutation is within the kinase domain.

    Amino acid replacement: W?term.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    slpr3P5 displays partial embryonic lethality; no male hemizygous escapers are observed.

    slpr3P5/Y mutants (lacking zygotic slpr function) show embryonic lethality and may have a dorsal open phenotype. Mutant embryos derived from homozygous female germline clones (lacking both zygotic and maternal slpr function) show a more severe lethality and cuticle phenotype than zygotically mutant embryos.

    29% of slprBS06/slpr3P5 escaper adult females have terminalia defects, with truncation of structures posterior to tergite 7, and are unable to defecate or lay eggs. 36% of the escaper females have maxillary palp defects.

    slpr3P5/Y embryos derived from heterozygous females die during embryogenesis or larval stages. Dead embryos have a variable dorsal open phenotype. A paternal copy of slpr+ can rescue embryos derived from females containing slpr3P5 homozygous germ-line clones. Mutant embryos derived from females containing homozygous germ-line clones which do not receive a paternal copy of slpr+ develop large anterior holes, due to severe defects in dorsal closure.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressed by
    Statement
    Reference

    slpr3P5 has lethal phenotype, suppressible by alphXS-88/alphXS-88

    slpr3P5 has lethal phenotype, suppressible by alphS-331/alphS-331

    Suppressor of
    Statement
    Reference

    slpr[+]/slpr3P5 is a suppressor of visible phenotype of Rac1GMR.PN

    Other
    Statement
    Reference
    Phenotype Manifest In
    Suppressed by
    Statement
    Reference

    slpr3P5 has phenotype, suppressible by pucE69/puc[+]

    Suppressor of
    Statement
    Reference

    slpr[+]/slpr3P5 is a suppressor of eye phenotype of Rac1GMR.PN

    slpr[+]/slpr3P5 is a suppressor of ommatidium phenotype of Rac1GMR.PN

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    pucE69/+ rescues slpr3P5/Y animals to adulthood. The mutant male flies are weakly viable with no gross morphological defects.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Partially rescued by
    Comments

    The lethality of slpr3P5 mutants is partially rescued by expression of slprScer\UAS.P\T.cPa or slprScer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS.

    The lethality of slpr3P5 mutants is not rescued by expression of slprAAA.Scer\UAS.P\T.T:Ivir\HA1, slprTAA.Scer\UAS.P\T.T:Ivir\HA1, slprASA.Scer\UAS.P\T.T:Ivir\HA1, slprSKLC.AAA.Scer\UAS.P\T.T:Ivir\HA1, slprSH3.Scer\UAS.P\T.T:Ivir\HA1, slprAVA.Scer\UAS.P\T.T:Ivir\HA1, slprΔSH3.Scer\UAS.P\T.T:Ivir\HA1, slprCterm.Scer\UAS.P\T.T:Ivir\HA1 or slprSKLC.Scer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS.

    Expression of slprAAT.Scer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS in slpr3P5 mutants results in the recovery of a few rescued adults and many more rescued animals are observed as pharate adults.

    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (5)