FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\slprSKLC.AAA.UASp.Tag:HA
Open Close
General Information
Symbol
Dmel\slprSKLC.AAA.UASp.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0246990
Feature type
allele
Associated gene
Dmel\slpr
Associated Insertion(s)
Carried in Construct
P{UASp-slpr.SKLC.AAA}
Key Links
Transgenic product class
inframe_deletion
(Garlena et al., 2010)
missense_variant
(Garlena et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Garlena et al., 2010)
missense_variant
(Garlena et al., 2010)
Mutagen
in vitro construct
(Garlena et al., 2010)
Progenitor genotype
Carried in construct
P{UASp-slpr.SKLC.AAA}
Cytology
Description

UASp regulatory sequences drive expression of a C-terminally truncated form of slpr (amino acid residues 1-516 are present) which contains the amino acid replacements T287A, S291A and T295A and which is tagged at the C-terminal end with two copies of Tag:HA.

(Garlena et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
slpr
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of slprSKLC.AAA.Scer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4pnr-MD237 results in defects in dorsal closure of the adult thorax (resulting in midline thorax clefts and widening of the space between adjacent dorsocentral bristles).

      (Garlena et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      slprSKLC.AAA.UASp.Tag:HA/Scer\GAL4arm.PS fails to rescue slprBS06

      (Garlena et al., 2010)

      slprSKLC.AAA.UASp.Tag:HA/Scer\GAL4arm.PS fails to rescue slpr3P5

      (Garlena et al., 2010)

      slprSKLC.AAA.UASp.Tag:HA/Scer\GAL4arm.PS fails to rescue slpr921

      (Garlena et al., 2010)
      Comments

      Expression of slprSKLC.AAA.Scer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS fails to rescue the lethality of slprBS06, slpr921 and slpr3P5 mutants.

      Expression of slprSKLC.AAA.Scer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS fails to rescue the severe dorsal open phenotype of slpr921 embryos.

      (Garlena et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      slprSKLC.AAA.Scer\UAS.P\T.T:Ivir\HA1
      slprSKLC.AAA.UASp.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)