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General Information
Symbol
Dmel\gfr1
Species
D. melanogaster
Name
FlyBase ID
FBal0246076
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygous clones in the eye (induced using the eyFLP technique) overgrow relative to their wild-type neighbours, without overall hyperplasia of the eye.

    Primary pigment cells are often missing or in inappropriate locations around the ommatidium in homozygous clones in the pupal retina and many of the mutant ommatidia have fewer than the normal number of cone cells.

    Mosaic animals in which the eyes and head cuticle are composed almost entirely of homozygous tissue (generated using the Minute technique) have significantly larger eyes than controls.

    Mosaic animals in which the wing disc is composed almost entirely of homozygous tissue (generated using the Minute technique) give rise to adults with patterning defects in the wings; wing vein L5 does not reach the margin (70% penetrance) and the wings are consistently smaller along the proximal-distal axis than control wings.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressed by
    Statement
    Reference

    gfr1, pucE69/puc[+] has lethal | dominant phenotype, suppressible by bru305871/l(3)05871[+]

    gfr1, pucE69/puc[+] has lethal | dominant phenotype, suppressible by Df(3L)Exel6119/+

    Other
    Statement
    Reference

    bru305871/l(3)05871[+], gfr1 has viable phenotype

    bru305871/l(3)05871[+], gfr1, pucE69/puc[+] has viable phenotype

    Phenotype Manifest In
    NOT Enhanced by
    Statement
    Reference

    gfr1 has eye | somatic clone phenotype, non-enhanceable by Df(1)N-54l9/+

    gfr1 has eye | somatic clone phenotype, non-enhanceable by bsk1/bsk[+]

    gfr1 has eye | somatic clone phenotype, non-enhanceable by cdc2[+]/Cdk1B47

    Suppressed by
    Statement
    Reference

    gfr1 has eye | somatic clone phenotype, suppressible by Ras85De2F/Ras85D[+]

    gfr1 has eye | somatic clone phenotype, suppressible by rl[+]/rl10a

    gfr1 has eye | somatic clone phenotype, suppressible by yki[+]/ykiB5

    NOT suppressed by
    Statement
    Reference

    gfr1 has eye | somatic clone phenotype, non-suppressible by Df(1)N-54l9/+

    gfr1 has eye | somatic clone phenotype, non-suppressible by bsk1/bsk[+]

    gfr1 has eye | somatic clone phenotype, non-suppressible by cdc2[+]/Cdk1B47

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The ommatidial patterning defects seen in homozygous gfr1 clones in the pupal eye disc are not suppressed by Ras85De2F.

    gfr1 dominantly suppresses the wing notching phenotype seen in Df(1)N-54l9 heterozygotes (the penetrance of the phenotype is significantly decreased in the double heterozygotes).

    The enlarged eye phenotype seen in mosaic animals in which the eye is homozygous for gfr1 is not modified by Df(1)N-54l9/+, cdc2B47/+ or bsk1/+.

    The enlarged eye phenotype seen in mosaic animals in which the eye is homozygous for gfr1 is suppressed if the animals are also carrying either Ras85De2F/+, rl10a/+ or ykiB5/+.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (1)