FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HUAS.cMa
Open Close
General Information
Symbol
Dmel\HUAS.cMa
Species
D. melanogaster
Name
FlyBase ID
FBal0280527
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-H, UAS-HFL, UAS-Hairless
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

UASt sequences drive expression of the H cDNA.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

dorsal row & sensory mother cell, with Scer\GAL4ap-md544

Detailed Description
Statement
Reference

The expression of HUAS.cMa under the control of Scer\GAL4GMR.PU induces a small, rough eye phenotype. Expression under the control of Scer\GAL4ptc-559.1 induces a small wing and venation defects, particularly in the anterior crossvein.

Overexpression of HScer\UAS.cMa during early eye development under the control of Scer\GAL4ey.PH causes dramatic tissue loss. Most animals die as pharate adults, because they fail to eclose from the pupal case due to the lack of eyes and parts of the head capsule. At 25[o]C, Scer\GAL4ey.PH>HScer\UAS.cMa causes lethality with nearly complete penetrance, whereas at 18[o]C, phenotypes are milder.

Overexpression of HScer\UAS.cMa along the antero-posterior axis in the developing wing using Scer\GAL4ptc-559.1 causes a large incision at the wing tip and a smaller distance between longitudinal veins L3 and L4. At 25[o]C, most animals die as pharate adults.

Overexpression of HScer\UAS.cMa in the posterior compartment using Scer\GAL4en.PU results in loss of tissue and notches in the wing margin.

Overexpression of HScer\UAS.cMa during bristle development using Scer\GAL4sca.PC results in bristle loss and socket to shaft transformation at 18[o]C. At 25[o]C, Scer\GAL4sca.PC>HScer\UAS.cMa causes nearly complete pharate lethality.

Expression of HScer\UAS.cMa under the control of Scer\GAL4GMR.PU results in small, rough eyes.

Expression of HScer\UAS.cMa in the eye under the control of Scer\GAL4GMR.PU results in a rough-eye phenotype, and a size reduction of the adult eye by nearly 50%. In early pupal development, death of cone cells is observed and only 2-3 cone cells remain. At 60 hours after puparium formation eye discs show extensive signs of cell disorganisation and distint cell types are no longer detectable.

Expression of HScer\UAS.cMa in the larval eye disc (under the control of heat-shock induced Scer\GAL4Act5C.PP) results in increased levels of cell death.

The overall number and positioning of the longitudinal glia in the embryo is not altered by expression of HScer\UAS.cMa under the control of Scer\GAL4htl.POS.

Expression of HScer\UAS.cMa under the control of Scer\GAL4GMR.PF results in an increase in the number of apoptotic cells in the area of ectopic HScer\UAS.cMa expression in the third larval instar eye disc. The adults produced have small, rough eyes. Expression of HScer\UAS.cMa under the control of Scer\GAL4bi-md653 results in an increase in the number of apoptotic cells in the area of ectopic HScer\UAS.cMa expression in the third larval instar wing disc. The adults produced have notched wings.

Expression of HScer\UAS.cMa under the control of Scer\GAL4bi-md653 in the wing severely inhibits growth and results in wing margin defects, thickening of the veins, and aberrant bristles.

When HScer\UAS.cNa is driven by Scer\GAL4GMR.PF flies have eyes that are slightly smaller along the anterior posterior axis and show ommatidial fusion and interommatidial bristle tufting, as well as bristle loss.

Expression of HScer\UAS.cNa under the control of Scer\GAL4en-e16E results in small patches of ectopic vein and irregular vein thickening in the wing. No ectopic bristles are produced. Loss of wing tissue and wing margin is seen.

HScer\UAS.cNa when driven by Scer\GAL4Bx-MS1096, produces flies with that frequently have split bristles due to a socket to shaft transformation, plus naked patches resulting from a pIIa to pIIb transformation.

When expression is driven by Scer\GAL4ap-md544, over commitment of some of the dorsal row of wing margin sensory organ precursors (SOPs) is seen, others are abolished. The ACV and L3 precursors of campaniform sensilla are also over committed and supernumerary SOPs are seen. In contrast to m4Scer\UAS.cAa and Scer\UAS.cAa, over expression of HScer\UAS.cMa driven by Scer\GAL4ap-md544, produced naked patches or double-shaft socketless bristles.

When expressed under the control of Scer\GAL4ptc-559.1 produces a notched wing tip phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by brm2

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by dsh1

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by so1

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, enhanceable by Bar1

NOT Enhanced by
Statement
Reference

HUAS.cMa, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by brnfs.107

HUAS.cMa, Scer\GAL4GMR.PU has visible phenotype, non-enhanceable by egh7

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-enhanceable by Df(1)HF368

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-enhanceable by Df(2L)RF

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-enhanceable by Df(2L)spd

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-enhanceable by Df(3L)Awh2

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-enhanceable by Df(3R)Cha9

Suppressed by
Statement
Reference

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, suppressible by amn1

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, suppressible by aop1

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, suppressible by baz4

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, suppressible by bsk1

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, suppressible by dap4

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, suppressible by ifB2

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, suppressible by mewM6

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, suppressible by nej3

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, suppressible by nejQ7

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, suppressible by Rok1

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, suppressible by tkv1

NOT suppressed by
Statement
Reference

HUAS.cMa, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by Df(2L)ED206

HUAS.cMa, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by egh7

HUAS.cMa, Scer\GAL4GMR.PU has visible phenotype, non-suppressible by brnfs.107

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-suppressible by Df(1)HF368

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-suppressible by Df(1)m259-4

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-suppressible by Df(2L)RF

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-suppressible by Df(2L)spd

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-suppressible by Df(3L)Awh2

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-suppressible by Df(3R)Cha9

HUAS.cMa, Scer\GAL4GMR.PF has visible phenotype, non-suppressible by Df(3R)kar3l

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, enhanceable by snaSco

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, enhanceable by S[+]/SIIN

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by SerRX102

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by brm2

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by dsh1

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by pucE69

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by so1

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by wdbdw

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Diap14

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Arl1N6

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Bar1

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by CycB2

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Df(1)B25

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Df(1)N-8

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Df(2R)B5

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by Rho1E.10

NOT Enhanced by
Statement
Reference

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by brnfs.107

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by Df(2L)Exel7014

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by Df(2L)ED206

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, non-enhanceable by egh7

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-enhanceable by Df(1)HF368

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-enhanceable by Df(1)m259-4

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-enhanceable by Df(2L)RF

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-enhanceable by Df(2L)spd

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-enhanceable by Df(3L)Awh2

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-enhanceable by Df(3L)emc-E12

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-enhanceable by Df(3R)Cha9

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-enhanceable by Df(3R)kar3l

Suppressed by
Statement
Reference

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, suppressible by argos[+]/aosrlt

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, suppressible by aop[+]/aop1

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, suppressible by klu[+]/klu09036

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, suppressible by lz1/lz[+]

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by SmrG0361

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by amn1

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by aop1

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by baz4

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by bsk1

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by dap4

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by dve01738

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by edk01102

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by ftG-rv

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by hepv39

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by hepv75

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by ifB2

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by klu09036

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by mewM6

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by msn06946

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by nej3

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by nejQ7

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Rok1

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by sdETX4

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by sty226

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by tkv1

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Df(1)C52

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Df(1)HA92

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Df(1)N105

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Df(1)N12

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Df(1)r-D1

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Df(2R)X1

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Df(3L)H99/+

NOT suppressed by
Statement
Reference

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by Df(2L)Exel7014

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by Df(2L)ED206

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by egh7

HUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by brnfs.107

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by Df(1)m259-4

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by Df(2L)RF

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by Df(2L)spd

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by Df(3L)Awh2

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by Df(3L)emc-E12

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by Df(3R)Cha9

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by Df(3R)crb-F89-4

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by Df(3R)kar3l

HUAS.cMa, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by Df(1)HF368

Enhancer of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of α4GT1EP797 has no effect on the small, rough eye phenotype caused by expression of HScer\UAS.cMa under the control of Scer\GAL4GMR.PU.

snaSco enhances the small, rough eye phenotype caused by expression of HScer\UAS.cMa under the control of Scer\GAL4GMR.PU.

The eye phenotype caused by expression of HScer\UAS.cMa under the control of Scer\GAL4GMR.PU is unaffected if the flies also carry either egh7, brnfs.107, Df(2L)Exel7014 or Df(2L)ED206.

The small-eye phenotype observed in animals expressing HScer\UAS.cMa in the eye under the control of Scer\GAL4GMR.PU is partially suppressed in a argosrlt/+ or aop1/+ mutant background. The eye phenotype is enhanced in a SIIN/+ background.

The small-eye phenotype observed in animals expressing HScer\UAS.cMa in the eye under the control of Scer\GAL4GMR.PU is significantly suppressed in a klu09036/+ or lz1/+ mutant background.

Co-expression of HScer\UAS.cMa and Su(H)Scer\UAS.cNa in the wing under the control of Scer\GAL4bi-md653 results in larval or early pupal lethality. Discs are severely distorted and extensive apoptosis is observed.

The addition of freddsRNA.Scer\UAS enhances the effect of HScer\UAS.cNa (driven by Scer\GAL4GMR.PF) on eye morphology.

The small patches of ectopic vein that are produced by expression of HScer\UAS.cNa under the control of Scer\GAL4en-e16E are suppressed by rhove-1/rhove-1. Loss of distal veins seems more pronounced in this double mutant combination.

Xenogenetic Interactions
Statement
Reference

Expression of BacA\p35GMR.PH in flies expressing HScer\UAS.cMa in the eye under the control of Scer\GAL4GMR.PU suppresses the small-eye phenotype, but does not rescue the irregular arrangement of the ommatidia. In pupal eye discs, the number of cone cells is restored to normal numbers (four).

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
HScer\UAS.cMa
HScer\UAS.cNa
HUAS.cMa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Maier
Saccharomyces cerevisiae UAS construct a of Nagel
Secondary FlyBase IDs
  • FBal0101654
  • FBal0117735
References (15)