FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cnkE-2083
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General Information
Symbol
Dmel\cnkE-2083
Species
D. melanogaster
Name
FlyBase ID
FBal0093979
Feature type
allele
Associated gene
Dmel\cnk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Therrien et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q257term.

(Therrien et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:17,418,478..17,418,478 [-]
Nucleotide change:

C17418478T

Amino acid change:

Q257term | cnk-PA; Q257term | cnk-PB

Reported amino acid change:

Q257term

Comment:

Site of nucleotide substitution inferred by FlyBase based on reported amino acid change.

(Therrien et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurofibromatosis
      modeled by Nf1E2
      (Walker et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant clones in the eye cause the eye to be reduced and malformed. The phenotype is similar to that seen for mutant Ras85D and ksr eye clones.

      (Therrien et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      cnkE-2083 is an enhancer of visible phenotype of HUAS.cMa, Scer\GAL4GMR.PF

      (Müller et al., 2005)
      Suppressor of
      Statement
      Reference

      cnk[+]/cnkE-2083 is a suppressor of decreased body size | pupal stage phenotype of Nf1E2

      (Walker et al., 2013)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      cnkE-2083 is an enhancer of eye phenotype of HUAS.cMa, Scer\GAL4GMR.PF

      (Müller et al., 2005)

      cnkE-2083 is an enhancer of eye phenotype of ksr::torΔNksr.hs.sev

      (Therrien et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cnkE-2083
      (Chammout et al., 2024, Walker et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)