FlyBase Allele Report: Dmel\tkv[1]

General Information

Symbol

Dmel\tkv¹

Species

D. melanogaster

Name

FlyBase ID

FBal0016818

Feature type

allele

Associated gene

Dmel\tkv

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(de Celis, 1997)

Mutagen

spontaneous

(Terracol and Lengyel, 1994)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with tkv⁷)

(McCabe et al., 2004)

abnormal neuroanatomy (with tkv⁸)

(McCabe et al., 2004)

abnormal neurophysiology (with tkv⁸)

(McCabe et al., 2004)

lethal - all die before end of larval stage (with tkv⁷)

(McCabe et al., 2004)

some die during larval stage (with tkv⁷)

(McCabe et al., 2004)

viable

(de Celis, 1997, Staehling-Hampton et al., 1995)

viable (with tkv⁸)

(McCabe et al., 2004)

visible (with Df(2L)tkv3)

(Kahsai and Cook, 2018)

visible | cold sensitive

(Terracol and Lengyel, 1994)

Phenotype Manifest In

bouton (with tkv⁸)

(McCabe et al., 2004)

first posterior wing cell

(Palsson and Gibson, 2000)

neuromuscular junction (with tkv⁷)

(McCabe et al., 2004)

neuromuscular junction (with tkv⁸)

(McCabe et al., 2004)

submarginal wing cell

(Palsson and Gibson, 2000)

wing vein

(Marenda et al., 2004, de Celis, 1997, Staehling-Hampton et al., 1995, Sturtevant and Bier, 1995, Terracol and Lengyel, 1994)

wing vein (with Df(2L)tkv3)

(Kahsai and Cook, 2018)

wing vein L4 | distal

(de Celis, 1997)

Detailed Description

Statement

Reference

tkv¹ heterozygous females show the expected mating-induced increase in germline stem cells in the germarium.

(Ameku et al., 2018)

tkv¹/Df(2L)tkv3 results in thickened wing veins.

(Kahsai and Cook, 2018)

mesothoracic tergum & macrochaeta | ectopic tkv¹ flies occasionally display ectopic bristles anterior to the anterior dorso-central bristle, when raised at 18^oC.

(Gibert et al., 2005)

tkv¹/tkv⁷ animals survive until the third larval instar and show a dramatic reduction in neuromuscular junction (NMJ) size compared to wild type. tkv¹/tkv⁸ animals show a significant reduction in neuromuscular junction (NMJ) size compared to wild type; the number of synaptic boutons/muscle surface area at muscle 6/7 is 71.6 +/- 1.9% of wild type. The evoked excitatory junctional potential (EJP) (measured at muscle 6 of segment A3) shows a decrease in amplitude in tkv¹/tkv⁸ animals compared to wild type. Quantal content is reduced compared to wild type.

(McCabe et al., 2004)

Heterozygotes show a quantitative effect on wing shape in intervein regions B and C compared to wild type.

(Palsson and Gibson, 2000)

tkv¹/tkv⁸ flies have variable thickening of the wing veins, particularly in regions close to the cross veins and at the distal ends of all longitudinal veins. tkv¹/tkv⁷ flies have some wing vein thickening, and lack distal stretches of vein LIV.

(de Celis, 1997)

Thickened vein mutant.

(Sturtevant and Bier, 1995)

Thickening and abnormal branching of the wing veins in the region of intersection with the crossveins and near the ends of the longitudinal veins.

(Terracol and Lengyel, 1994)

Homozygotes have a weak phenotype, hemizygotes have thickening of longitudinal and transverse veins.

(Diaz-Benjumea and Garcia-Bellido, 1990)

homozygous viable with thick veins Veins thickened and branched in region of crossveins, near end of L2, and elsewhere. Sometimes a blister near posterior crossvein in female; L4 sometimes shortened, especially in female. Female more extreme than male. Easier to identify at 19^oC. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

tkv¹/tkv[+] is an enhancer of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

tkv¹/tkv[+] is an enhancer of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

Suppressor of

Statement

Reference

tkv¹/tkv⁷ is a suppressor of abnormal neuroanatomy phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv¹/tkv[+] is a suppressor of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

tkv¹ is a suppressor of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

tkv¹ is a suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

tkv¹/tkv[+] is a suppressor | partially of visible phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

Other

Statement

Reference

NPFR^sk8, tkv¹/tkv[+] has decreased cell number | oogenesis | conditional phenotype

(Ameku et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

tkv¹ has mesothoracic tergum & macrochaeta | ectopic phenotype, enhanceable by pad¹

(Gibert et al., 2005)

tkv¹ has wing vein phenotype, enhanceable by Snr1^E1/Snr1^E1

(Marenda et al., 2004)

tkv¹ has wing vein phenotype, enhanceable by Snr1^E1/Snr1[+]

(Marenda et al., 2004)

tkv¹/tkv⁸ has wing vein phenotype, enhanceable by N^nd-3

(de Celis, 1997)

tkv¹/Df(2L)tkv2 has wing vein phenotype, enhanceable by shn¹

(Staehling-Hampton et al., 1995)

Suppressed by

Statement

Reference

tkv¹ has wing vein | ectopic phenotype, suppressible by brm^unspecified

(Marenda et al., 2004)

tkv¹/tkv⁸ has phenotype, suppressible by dpp^s4/dpp^s8

(de Celis, 1997)

tkv¹/tkv⁸ has wing vein phenotype, suppressible by rho^ve-1

(de Celis, 1997)

tkv¹/tkv⁸ has wing vein phenotype, suppressible by N^Ax-1

(de Celis, 1997)

Enhancer of

Statement

Reference

tkv¹ is an enhancer of mesothoracic tergum & macrochaeta | ectopic phenotype of pad¹

(Gibert et al., 2005)

tkv¹/tkv[+] is an enhancer of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

tkv¹/tkv[+] is an enhancer of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

tkv¹/tkv⁸ is an enhancer of wing vein | ectopic phenotype of Ras64B^Act5C.PC

(de Celis, 1997)

tkv¹/tkv⁸ is an enhancer of wing vein phenotype of dpp^s4/dpp^s8

(de Celis, 1997)

tkv¹/tkv⁸ is an enhancer of wing vein phenotype of rho^hs.PSt

(de Celis, 1997)

NOT Enhancer of

Statement

Reference

tkv¹ is a non-enhancer of wing | somatic clone phenotype of ft^k07918

(Garoia et al., 2005)

Suppressor of

Statement

Reference

tkv¹/tkv⁷ is a suppressor of eye disc phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv¹/tkv⁷ is a suppressor of glial cell phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

tkv¹/tkv[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

tkv¹ is a suppressor of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

tkv¹ is a suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

tkv¹/tkv[+] is a suppressor | partially of wing phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

NOT Suppressor of

Statement

Reference

tkv¹ is a non-suppressor of wing | somatic clone phenotype of ft^k07918

(Garoia et al., 2005)

Other

Statement

Reference

NPFR^sk8, tkv¹/tkv[+] has female germline stem cell | conditional phenotype

(Ameku et al., 2018)

tkv¹/Df(2L)tkv2, shn¹ has unguis phenotype

(Staehling-Hampton et al., 1995)

tkv¹/tkv⁷, vvl^sep has wing vein L2 phenotype

(de Celis et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

NPFR^sk8, tkv¹ double heterozygous females fail to show the expected mating-induced increase in germline stem cells in the germarium, as compared to heterozygous controls.

(Ameku et al., 2018)

The glial overmigration phenotype seen in spin¹⁰⁴⁰³ eye discs is significantly suppressed if the animals are also carrying tkv¹/tkv⁷.

(Yuva-Aydemir et al., 2011)

tkv¹ pad¹ double mutants show an enhanced ectopic bristle phenotype compared to either single mutant; there are particularly more ectopic bristles present around the presutal suture.

(Gibert et al., 2005)

The tkv¹/tkv¹ wing vein phenotype is enhanced by Snr1^E1/+ at 25^oC, and is further enhanced by Snr1^E1/Snr1^E1 at 25^oC.

(Marenda et al., 2004)

The dpp shortvein phenotype is strongly enhanced, and the tkv phenotype is suppressed, in dpp^s4 tkv¹/dpp^s8 tkv⁸ double mutant flies. rho^ve-1 suppresses the differentiation of thicker veins seen in tkv¹/tkv⁸ flies. The differentiation of thicker veins seen in rho^hs.PSt flies is strongly increased in combination with tkv¹/tkv⁸. The ectopic vein phenotype of Ras64B^Act5C.PC flies is increased in combination with tkv¹/tkv⁸. tkv¹/tkv⁸ N^Ax-1 double mutant flies show pronounced wing vein loss. The thickening of veins seen in tkv¹/tkv⁸ flies is strongly enhanced in combination with N^nd-3 and is suppressed in combination with N^Ax-1.

(de Celis, 1997)

shn¹ enhances the wing vein thickening of tkv¹/Df(2L)tkv2. Some tkv¹/Df(2L)tkv2, shn¹ flies are missing terminal leg claws.

(Staehling-Hampton et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

tkv¹/tkv⁸ is rescued by Scer\GAL4^elav.PLu/tkv^UAS.Tag:HA

(McCabe et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

427

105906

Notes on Origin

Discoverer

Nichols-Skoog, 25th Feb. 1933.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tkv¹

(Klaustermeier et al., 2025, Deichsel et al., 2024, Deichsel et al., 2024, Ameku et al., 2018, Kahsai and Cook, 2018, Chauhan et al., 2013, Liu et al., 2011, Quijano et al., 2011, Yuva-Aydemir et al., 2011, Ellis et al., 2010, Dudu, 2006, Oishi et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (27)

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