FlyBase Allele Report: Dmel\Imp[EP1433]

General Information

Symbol

Dmel\Imp^EP1433

Species

D. melanogaster

Name

FlyBase ID

FBal0123149

Feature type

allele

Associated gene

Dmel\Imp

Associated Insertion(s)

P{EP}Imp^EP1433

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Kraut et al., 2001, Kraut et al., 2001)

Progenitor genotype

Associated Insertion(s)

P{EP}Imp^EP1433

Cytology

Description

The P{EP} element is inserted 1548 nucleotides 5' to the predicted ATG start codon.

(Kraut et al., 2001)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:10,806,896..10,806,896 [-]

(Sofola et al., 2007, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Bilen and Bonini, 2007)

ameliorates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Bilen and Bonini, 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

Phenotype Manifest In

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

Detailed Description

Statement

Reference

Expression of Imp^EP1433 under the control of Scer\GAL4^GMR.PF has no affect on the eye.

(Müller et al., 2005)

Mutant larvae expressing Imp^EP1433 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses.

(Kraut et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Imp^EP1433, Scer\GAL4^GMR.PU is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Imp^EP1433, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Imp^EP1433, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Scer\GAL4^GMR.PU/Imp^EP1433 is a suppressor of visible phenotype of hid^GMR.PG

(Bilen and Bonini, 2007)

Scer\GAL4^GMR.PF/Imp^EP1433 is a suppressor | partially of visible phenotype of p53^GMR.Ex

(Müller et al., 2005)

Scer\GAL4^GMR.PF/Imp^EP1433 is a suppressor of visible phenotype of rpr^GMR.PW

(Müller et al., 2005)

Imp^EP1433, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

Scer\GAL4^GMR.PF/Imp^EP1433 is a suppressor of visible phenotype of hid^GMR.PG

(Müller et al., 2005)

Scer\GAL4^GMR.PF/Imp^EP1433 is a suppressor of visible phenotype of grim^GMR.PC

(Müller et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Imp^EP1433, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Imp^EP1433, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Imp^EP1433, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Scer\GAL4^GMR.PU/Imp^EP1433 is a suppressor of eye phenotype of hid^GMR.PG

(Bilen and Bonini, 2007)

Scer\GAL4^GMR.PF/Imp^EP1433 is a suppressor | partially of eye phenotype of p53^GMR.Ex

(Müller et al., 2005)

Scer\GAL4^GMR.PF/Imp^EP1433 is a suppressor of eye phenotype of rpr^GMR.PW

(Müller et al., 2005)

Imp^EP1433, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

Scer\GAL4^GMR.PF/Imp^EP1433 is a suppressor of eye phenotype of hid^GMR.PG

(Müller et al., 2005)

Scer\GAL4^GMR.PF/Imp^EP1433 is a suppressor of eye phenotype of grim^GMR.PC

(Müller et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Imp^EP1433 is a strong suppressor of the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

(Bilen and Bonini, 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Imp^EP1433

(Bilen and Bonini, 2007)

imp^EP1433

(Sofola et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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