FlyBase Allele Report: Hsap\HSPA1L[K71E.UAS]

General Information

Symbol

Hsap\HSPA1L^K71E.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0212634

Feature type

allele

Associated gene

Hsap\HSPA1L

Associated Insertion(s)

Carried in Construct

P{UAS-Hsp70.K71E}

Also Known As

UAS-Hsp70.K71E

Key Links

Transgenic product class

dominant_negative_variant

(Bonini, 2002)

missense_variant

(Bonini, 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

dominant_negative_variant

(Bonini, 2002)

missense_variant

(Bonini, 2002)

Mutagen

in vitro construct

(Bonini, 2002)

Progenitor genotype

Hsap\HSPA1L^UAS.cWa

(Bonini, 2002)

Carried in construct

P{UAS-Hsp70.K71E}

Cytology

Description

Encodes a dominant negative form of Hsap\HSPA1L.

(Bonini, 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\HSPA1L

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^GMR.PF

(Warrick et al., 2005, Bonini, 2002)

visible, with Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Warrick et al., 2005, Bonini, 2002)

eye, with Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Detailed Description

Statement

Reference

Expression of Hsap\HSPA1L^{K71E.Scer\UAS} under the control of Scer\GAL4^GMR.PU results in degeneration of the eye.

(Bilen and Bonini, 2007)

Flies expressing Hsap\HSPA1L^{K71E.Scer\UAS} under the control of Scer\GAL4^GMR.PF have a severely disrupted eye.

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the mutant eye phenotype caused by expression of Hsap\HSPA1L^{K71E.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Warrick et al., 2005)

Flies expressing Hsap\HSPA1L^{K71E.Scer\UAS} under the control of Scer\GAL4^GMR.PF show loss of eye pigmentation and deterioration of eye structure.

(Bonini, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by DnaJ-1^B345.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by DnaJ-1^EP411, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Tpr2^EB7-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Acox1^B227.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

NOT Enhanced by

Statement

Reference

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Usp47^E213-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Suppressed by

Statement

Reference

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Hsp68^E407, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by CG14207^EP1348, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by CG11700^EP1384, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by CG8209^B3-Sa, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Faf2^E659, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Kdm2^EP3093, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by emb^E2-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by emb^E128-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Sin3A^B9-E, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by NFAT^EP1335, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by NFAT^EP1508, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by dbr^EP456, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by dbr^EP9, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by wech^JM120, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by wech^JM265, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by wech^E546, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by wech^EP2594, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by orb2^B8-S, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Imp^EP1433, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PF has visible phenotype, suppressible | partially by CG11700^EP1384, Scer\GAL4^GMR.PF

(Warrick et al., 2005)

NOT suppressed by

Statement

Reference

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Usp47^E213-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}, Scer\GAL4^GMR.PF

(Warrick et al., 2005)

Other

Statement

Reference

DnaJ-1^B345.2, Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has lethal - all die during pupal stage phenotype

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU, Tpr2^EB7-1A has lethal - all die during pupal stage phenotype

(Bilen and Bonini, 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by DnaJ-1^B345.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by DnaJ-1^EP411, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Tpr2^EB7-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Acox1^B227.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

NOT Enhanced by

Statement

Reference

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Usp47^E213-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Suppressed by

Statement

Reference

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG8209^B3-Sa, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Faf2^E659, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Kdm2^EP3093, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by emb^E2-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by emb^E128-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Sin3A^B9-E, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by NFAT^EP1335, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by NFAT^EP1508, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by dbr^EP456, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by dbr^EP9, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^JM120, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^JM265, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^E546, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^EP2594, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by orb2^B8-S, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Imp^EP1433, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hsp68^E407, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG14207^EP1348, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG11700^EP1384, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible | partially by CG11700^EP1384, Scer\GAL4^GMR.PF

(Warrick et al., 2005)

NOT suppressed by

Statement

Reference

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Usp47^E213-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}, Scer\GAL4^GMR.PF

(Warrick et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\MJD^{fl.Q27.Scer\UAS.T:Hsap\MYC} has little or no effect on the mutant eye phenotype caused by expression of Hsap\HSPA1L^{K71E.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

Co-expression of CR11700^EP1384 partially suppresses the mutant eye phenotype caused by expression of Hsap\HSPA1L^{K71E.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Warrick et al., 2005)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

HSP70K71E

(Shukla et al., 2014)

Hsap\HSPA1L^{K71E.Scer\UAS}

Hsap\HSPA1L^K71E.UAS

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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