FlyBase Allele Report: Dmel\DnaJ-1[B345.2]

General Information

Symbol

Dmel\DnaJ-1^B345.2

Species

D. melanogaster

Name

FlyBase ID

FBal0283215

Feature type

allele

Associated gene

Dmel\DnaJ-1

Associated Insertion(s)

P{EP}DnaJ-1^B345.2

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EP}DnaJ-1^B345.2

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Bilen and Bonini, 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

DnaJ-1^B345.2, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Suppressor of

Statement

Reference

DnaJ-1^B345.2, Scer\GAL4^GMR.PU is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Scer\GAL4^GMR.PU, Prosβ6^1.B.UAS/DnaJ-1^B345.2 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Other

Statement

Reference

DnaJ-1^B345.2, Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU has lethal - all die during pupal stage phenotype

(Bilen and Bonini, 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

DnaJ-1^B345.2, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Suppressor of

Statement

Reference

DnaJ-1^B345.2, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Scer\GAL4^GMR.PU, Prosβ6^1.B.UAS/DnaJ-1^B345.2 is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

DnaJ-1^B345.2 is a strong suppressor of the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

DnaJ-1^B345.2 is still able to suppress the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU when the flies also carry Prosβ6^1.B.Scer\UAS.

(Bilen and Bonini, 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

DnaJ-1^B345.2

(Bilen and Bonini, 2007)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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