FlyBase Allele Report: Dmel\Prosβ6[1.B.UAS]

General Information

Symbol

Dmel\Prosβ6^1.B.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0141582

Feature type

allele

Associated gene

Dmel\Prosβ6

Associated Insertion(s)

Carried in Construct

P{UAS-Prosβ6¹.B}

Also Known As

UAS-DTS5, UAS-Pros26¹, UAS-Prosβ6¹

Key Links

Transgenic product class

missense_variant

(Belote and Fortier, 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Belote and Fortier, 2002)

Mutagen

in vitro construct

(Belote and Fortier, 2002)

Progenitor genotype

Prosβ6¹

(Belote and Fortier, 2002)

Carried in construct

P{UAS-Prosβ6¹.B}

Cytology

Description

UASt regulatory sequences drive expression of the Prosβ6¹ mutant coding region.

(Belote and Fortier, 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Prosβ6

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Oh et al., 2015)

modeled by Zzzz\CGG^{100.5'UTR.UAS.GFP}

(Oh et al., 2015)

exacerbates nemaline myopathy 7

modeled by tsr^HMS00534

(Balakrishnan et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Belote and Fortier, 2002)

eye | adult stage | temperature conditional, with Scer\GAL4^GMR.PF

(Rui et al., 2015)

ommatidium, with Scer\GAL4^GMR.PF

(Belote and Fortier, 2002)

pupal thorax | heat sensitive, with Scer\GAL4^how-24B

(Zhu et al., 2017)

Detailed Description

Statement

Reference

Pupae expressing Prosβ6^1.B.UAS under the control of Scer\GAL4^how-24B raised at the non-permissive 25[o]C temperature lack the middle thoracic portion of their bodies, indicating degeneration of muscle tissue. There are no obvious defects at 18[o]C.

(Zhu et al., 2017)

Expression of Prosβ6^1.B.Scer\UAS under the control of Scer\GAL4^GMR.long does not induce rough eye phenotype in adult flies maintained at 28[o]C.

(Oh et al., 2015)

Expression of temperature-sensitive Prosβ6^1.B.Scer\UAS under the control of Scer\GAL4^GMR.PF results in rough eye phenotype at the non-permissive temperature of 28[o]C, at the permissive temperature (22[o]C) the eyes appear normal.

(Rui et al., 2015)

Co-expression of Prosβ2^1.Scer\UAS and Prosβ6^1.B.Scer\UAS under the control of Scer\GAL4^wor.PA does not induce larval neuroblast loss.

(Kuang et al., 2014)

Expression of Pros26^1.B.Scer\UAS at 29^oC under the control of Scer\GAL4^GMR.PF results in severely disrupted eyes, with fused facets and small spots of black, presumably necrotic, cells.

(Belote and Fortier, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has decreased body size | P-stage | heat sensitive phenotype, enhanceable by mask^HMS01045, Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has visible | heat sensitive phenotype, enhanceable by Tnks^GD11407, Scer\GAL4^GMR.PU

(Cho-Park and Steller, 2013)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has visible | heat sensitive phenotype, enhanceable by CG9588^HM05013, Scer\GAL4^GMR.PU

(Cho-Park and Steller, 2013)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has visible | heat sensitive phenotype, enhanceable by CG9588^GD14259, Scer\GAL4^GMR.PU

(Cho-Park and Steller, 2013)

Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Prosβ2^1.UAS, Scer\GAL4^GMR.PF

(Belote and Fortier, 2002)

NOT Enhanced by

Statement

Reference

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has lethal - all die before end of P-stage | heat sensitive phenotype, non-enhanceable by mask^HMS01045, Scer\GAL4^how-24B

(Zhu et al., 2017)

Suppressed by

Statement

Reference

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has lethal - all die before end of P-stage | heat sensitive phenotype, suppressible by mask^UAS.cZa, Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has decreased body size | P-stage | heat sensitive phenotype, suppressible by mask^UAS.cZa, Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has lethal - all die before end of P-stage | heat sensitive phenotype, suppressible | partially by Atg1²⁵/mask^UAS.cZa/Atg1[+], Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has lethal - all die before end of P-stage | heat sensitive phenotype, suppressible | partially by Atg2[+]/mask^UAS.cZa/Atg2^EP3697, Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has lethal - all die before end of P-stage | heat sensitive phenotype, suppressible | partially by Atg18a^KG03090/mask^UAS.cZa/Atg18a[+], Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has lethal - all die before end of P-stage | heat sensitive phenotype, suppressible | partially by mask^UAS.cZa/Vha68-2[+]/Vha68-2^EP2364, Scer\GAL4^how-24B

(Zhu et al., 2017)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.long has lethal phenotype, suppressible by Hsap\ATXN3^{UAS.Tag:polyHis}, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.long has lethal phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.long

(Tsou et al., 2015)

NOT suppressed by

Statement

Reference

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has lethal - all die before end of P-stage | heat sensitive phenotype, non-suppressible by mask^HMS01045, Scer\GAL4^how-24B

(Zhu et al., 2017)

Enhancer of

Statement

Reference

Prosβ6^1.B.UAS, Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zzzz\CGG^{100.5'UTR.UAS.GFP}

(Oh et al., 2015)

Prosβ6^1.B.UAS, Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP

(Oh et al., 2015)

Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Prosβ2^1.UAS, Scer\GAL4^GMR.PF

(Belote and Fortier, 2002)

NOT Enhancer of

Statement

Reference

Prosβ6^1.B.UAS, Scer\GAL4^Mhc.PW is a non-enhancer of abnormal locomotor behavior | larval stage | progressive phenotype of Scer\GAL4^Mhc.PW, tsr^HMS00534

(Balakrishnan et al., 2020)

Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PU, Prosβ6^1.B.UAS/DnaJ-1^B345.2 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

wech^JM265/Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

NOT Suppressor of

Statement

Reference

Prosβ6^1.B.UAS, Scer\GAL4^Mhc.PW is a non-suppressor of abnormal locomotor behavior | larval stage | progressive phenotype of Scer\GAL4^Mhc.PW, tsr^HMS00534

(Balakrishnan et al., 2020)

Scer\GAL4^GMR.PU, CG11700^EP1384/Prosβ6^1.B.UAS is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Usp47^E213-1A/Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Other

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.long has lethal phenotype

(Tsou et al., 2015)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has visible | heat sensitive phenotype

(Cho-Park and Steller, 2013)

CG9588^GD14259, Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has lethal | male limited | heat sensitive phenotype

(Cho-Park and Steller, 2013)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU, Tnks^KK100530 has lethal | heat sensitive phenotype

(Cho-Park and Steller, 2013)

PI31^GD13764, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has lethal | heat sensitive phenotype

(Bader et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has eye | heat sensitive phenotype, enhanceable by CG9588^HM05013, Scer\GAL4^GMR.PU

(Cho-Park and Steller, 2013)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has eye | heat sensitive phenotype, enhanceable by CG9588^GD14259, Scer\GAL4^GMR.PU

(Cho-Park and Steller, 2013)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has eye | heat sensitive phenotype, enhanceable by Tnks^GD11407, Scer\GAL4^GMR.PU

(Cho-Park and Steller, 2013)

Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Prosβ2^1.UAS, Scer\GAL4^GMR.PF

(Belote and Fortier, 2002)

NOT Enhanced by

Statement

Reference

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has pupal thorax | heat sensitive phenotype, non-enhanceable by mask^HMS01045, Scer\GAL4^how-24B

(Zhu et al., 2017)

Suppressed by

Statement

Reference

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has pupal thorax | heat sensitive phenotype, suppressible by mask^UAS.cZa, Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has pupal thorax | heat sensitive phenotype, suppressible | partially by Atg1²⁵/mask^UAS.cZa/Atg1[+], Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has pupal thorax | heat sensitive phenotype, suppressible | partially by Atg2[+]/mask^UAS.cZa/Atg2^EP3697, Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has pupal thorax | heat sensitive phenotype, suppressible | partially by Atg18a^KG03090/mask^UAS.cZa/Atg18a[+], Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has pupal thorax | heat sensitive phenotype, suppressible | partially by mask^UAS.cZa/Vha68-2[+]/Vha68-2^EP2364, Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has eye | heat sensitive phenotype, suppressible by PI31^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Bader et al., 2011)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible | partially by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible | partially by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

NOT suppressed by

Statement

Reference

Prosβ6^1.B.UAS, Scer\GAL4^how-24B has pupal thorax | heat sensitive phenotype, non-suppressible by mask^HMS01045, Scer\GAL4^how-24B

(Zhu et al., 2017)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has inclusion body | increased number phenotype, non-suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Enhancer of

Statement

Reference

Prosβ6^1.B.UAS, Scer\GAL4^Mhc.PW is an enhancer of larval somatic muscle cell | larval stage phenotype of Scer\GAL4^Mhc.PW, tsr^HMS00534

(Balakrishnan et al., 2020)

Prosβ6^1.B.UAS, Scer\GAL4^Mhc.PW is an enhancer of myotube | larval stage phenotype of Scer\GAL4^Mhc.PW, tsr^HMS00534

(Balakrishnan et al., 2020)

Prosβ6^1.B.UAS, Scer\GAL4^Mhc.PW is an enhancer of sarcomere | larval stage phenotype of Scer\GAL4^Mhc.PW, tsr^HMS00534

(Balakrishnan et al., 2020)

Prosβ6^1.B.UAS, Scer\GAL4^GMR.long is an enhancer of eye phenotype of Scer\GAL4^GMR.long, Zzzz\CGG^{100.5'UTR.UAS.GFP}

(Oh et al., 2015)

Prosβ6^1.B.UAS, Scer\GAL4^GMR.long is an enhancer of eye phenotype of Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP

(Oh et al., 2015)

Prosβ6^1.B.UAS/Prosβ2^1.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Mallik and Lakhotia, 2010)

Prosβ6^1.B.UAS/Prosβ2^1.UAS, Scer\GAL4^GMR.PF is an enhancer of inclusion body | increased number phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Mallik and Lakhotia, 2010)

Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Prosβ2^1.UAS, Scer\GAL4^GMR.PF

(Belote and Fortier, 2002)

NOT Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF, Prosβ6^1.B.UAS/Prosβ2^1.UAS is a non-enhancer of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PU, Prosβ6^1.B.UAS/DnaJ-1^B345.2 is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

wech^JM265/Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR.PU, CG11700^EP1384/Prosβ6^1.B.UAS is a non-suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Usp47^E213-1A/Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Other

Statement

Reference

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^fkh.PH has salivary gland phenotype

(Zhang et al., 2014)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^fkh.PH has nucleus phenotype

(Zhang et al., 2014)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has eye | heat sensitive phenotype

(Cho-Park and Steller, 2013, Bader et al., 2011)

PI31^GD13764, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU has eye phenotype

(Bader et al., 2011)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF has retina phenotype

(Mallik and Lakhotia, 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Flies co-expressing Prosβ6^1.B.Scer\UAS and Prosβ2^1.Scer\UAS under the control of Scer\GAL4^elav.PU at the non-permissive temperature 30[o]C are lethal at the third instar larval stage. When the flies are raised at 18[o]C and then incubated at 30[o]C for 4 weeks and exposed to the pesticides paraquat and/or maneb no dopaminergic neuron loss is observed.

(Martin et al., 2014)

Co-expression of Prosβ6^1.B.Scer\UAS and Prosβ2^1.Scer\UAS in the salivary gland under the control of Scer\GAL4^fkh.PH causes aberrant morphology of some salivary gland nuclei.

(Zhang et al., 2014)

Co-expression of Prosβ6^1.B.Scer\UAS and Prosβ2^1.Scer\UAS under the control of Scer\GAL4^GMR.PU at 29[o]C results in a rough eye phenotype. This phenotype is enhanced if the animals are also co-expressing either Tnks^GD11407 or CG9588^HM05013.

Co-expression of Prosβ6^1.B.Scer\UAS and Prosβ2^1.Scer\UAS under the control of Scer\GAL4^GMR.PU at 29[o]C results in a rough eye phenotype. This phenotype is enhanced in females if they are also co-expressing CG9588^GD14259.

Co-expression of Prosβ6^1.B.Scer\UAS, Prosβ2^1.Scer\UAS and Tnks^KK100530 under the control of Scer\GAL4^GMR.PU at 29[o]C results in lethality.

Co-expression of Prosβ6^1.B.Scer\UAS, Prosβ2^1.Scer\UAS and CG9588^GD14259 under the control of Scer\GAL4^GMR.PU at 29[o]C results in male lethality.

(Cho-Park and Steller, 2013)

Expression of both Pros26^1.B.Scer\UAS and Prosβ2^1.Scer\UAS using Scer\GAL4^GMR.PU at 29[o]C causes a rough eye phenotype.

Co-expression of PI31^{Scer\UAS.T:Ivir\HA1} suppresses the rough eye seen in flies expressing Pros26^1.B.Scer\UAS and Prosβ2^1.Scer\UAS using Scer\GAL4^GMR.PU at 29[o]C.

Whereas Scer\GAL4^GMR.PU-mediated expression of either Pros26^1.B.Scer\UAS or PI31^GD13764 alone gives no detectable eye phenotype at 25[o]C, their co-expression causes a strong eye phenotype. At 29[o]C, this combination is lethal.

(Bader et al., 2011)

Flies co-expressing Pros26^1.B.Scer\UAS and Prosβ2^1.Scer\UAS under the control of Scer\GAL4^GMR.PF at 25[o]C appear near normal. Additional co-expression of P{Sym-UAS-Hsrω} does not alter the external eye morphology. However, the pseudopupil images of flies expressing Pros26^1.B.Scer\UAS and Prosβ2^1.Scer\UAS reveal severe retinal damage, which is substantially rescued by additional co-expression of one copy of P{Sym-UAS-Hsrω}.

(Mallik and Lakhotia, 2010)

Expression of Pros26^1.B.Scer\UAS and Prosβ2^1.Scer\UAS in the developing tracheal system under the control of Scer\GAL4^btl.PS is sufficient to cause dorsal trunk breaks due to down-regulation of trh in embryonic fusion cells.

(Mortimer and Moberg, 2007)

Xenogenetic Interactions

Statement

Reference

The eye degeneration phenotype observed in adult flies expressing either Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} or Zzzz\CGG^{100.5'UTR.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^GMR.long (and maintained at 28[o]C) is significantly enhanced by co-expression of Prosβ6^1.B.Scer\UAS.

(Oh et al., 2015)

Co-expression of the temperature sensitive Prosβ6^1.B.Scer\UAS allele together with Hsap\MAPT^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^shot-OK307 has no adverse effect on the morphology and structure of the adult thorax or the thoracic somatic muscles below at either the non-permissive (28[o]C) or the permissive (22[o]C) temperatures.

(Rui et al., 2015)

Simultaneous co-expression of Prosβ6^1.B.Scer\UAS and Prosβ2^1.Scer\UAS does not suppress the protective role of expression of Hsap\ATXN3^{Scer\UAS.WT.T:Zzzz\His6} or DnaJ-1^Scer\UAS.cKa in suppression of eye degeneration in Scer\GAL4^GMR.long>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies.

Simultaneous co-expression of Prosβ6^1.B.Scer\UAS and Prosβ2^1.Scer\UAS leads to lethality in Scer\GAL4^GMR.long>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies; extra co-expression of Hsap\ATXN3^{Scer\UAS.WT.T:Zzzz\His6} or DnaJ-1^Scer\UAS.cKa suppresses this lethality.

(Tsou et al., 2015)

The eye damage caused by Scer\GAL4^GMR.PF-mediated expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is enhanced by co-expression of Pros26^1.B.Scer\UAS and Prosβ2^1.Scer\UAS. Co-expression of P{Sym-UAS-Hsrω} still suppresses the damage in Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Pros26^1.B.Scer\UAS, Prosβ2^1.Scer\UAS eyes, but the eyes are not rescued to the degree seen in Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} eyes.

The increase in inclusion bodies in larval eye discs caused by Scer\GAL4^GMR.PF-mediated expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is further increased by co-expression of Pros26^1.B.Scer\UAS and Prosβ2^1.Scer\UAS. However, co-expression of P{Sym-UAS-Hsrω} fails to reduce the number of inclusion bodies in the Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Pros26^1.B.Scer\UAS, Prosβ2^1.Scer\UAS background.

The damaged eye phenotype that results from Scer\GAL4^GMR.PF-mediated expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} is not further enhanced by co-expression of Pros26^1.B.Scer\UAS and Prosβ2^1.Scer\UAS. Co-expression of P{Sym-UAS-Hsrω} still suppresses the damage in Scer\GAL4^GMR.PF, Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Pros26^1.B.Scer\UAS, Prosβ2^1.Scer\UAS eyes, but the eyes are not rescued to the degree seen in Scer\GAL4^GMR.PF, Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} eyes.

(Mallik and Lakhotia, 2010)

Co-expression of Prosβ6^1.B.Scer\UAS does not enhance the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

In the presence of Prosβ6^1.B.Scer\UAS, CG11700^EP1384 cannot suppress the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

In the presence of Prosβ6^1.B.Scer\UAS, Ubp64E^E213-1A cannot suppress the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

DnaJ-1^B345.2 and wech^JM265 are each still able to suppress the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU when the flies also carry Prosβ6^1.B.Scer\UAS.

(Bilen and Bonini, 2007)

Complementation and Rescue Data

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Mutant

Wild-type

Stocks (2)

Bloomington

6786

w¹¹¹⁸; P{UAS-Prosβ6¹.B}2B

6787

w¹¹¹⁸; P{UAS-Prosβ6¹.B}2B; P{UAS-Prosβ2¹}1B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Pros26^1.B.Scer\UAS

Prosβ6^1.B.Scer\UAS

Prosβ6^1.B.UAS

Name Synonyms

Secondary FlyBase IDs

References (29)

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