FlyBase Allele Report: Dmel\DnaJ-1[EP411]

General Information

Symbol

Dmel\DnaJ-1^EP411

Species

D. melanogaster

Name

FlyBase ID

FBal0119670

Feature type

allele

Associated gene

Dmel\DnaJ-1

Associated Insertion(s)

P{EP}DnaJ-1^EP411

Carried in Construct

Also Known As

EP411

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-, Fernandez-Funez et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}DnaJ-1^EP411

Cytology

Description

The P{EP} insertion is 600bp upstream of the putative ATG start codon in the same orientation to the transcription unit.

(Fernandez-Funez et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:5,752,193..5,752,193 [-]

(Branco et al., 2008, Bilen and Bonini, 2007, Gene Disruption Project members, 2001-, Fernandez-Funez et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Bilen and Bonini, 2007)

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^30Q.UAS

(Fernandez-Funez et al., 2000)

modeled by Hsap\ATXN1^82Q.UAS

(Fernandez-Funez et al., 2000)

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Branco et al., 2008)

ameliorates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

DnaJ-1^EP411, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Suppressor of

Statement

Reference

DnaJ-1^EP411, Scer\GAL4^GMR.PU is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

DnaJ-1^EP411, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Suppressor of

Statement

Reference

DnaJ-1^EP411, Scer\GAL4^GMR.PU is a suppressor of retina phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Branco et al., 2008)

DnaJ-1^EP411, Scer\GAL4^GMR.PU is a suppressor of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

DnaJ-1^EP411, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

DnaJ-1^EP411, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

DnaJ-1^EP411, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of DnaJ-1^EP411 suppresses the retinal phenotype seen when Hsap\HTT^{128Q.1-336.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of DnaJ-1^EP411 suppresses the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

(Branco et al., 2008)

DnaJ-1^EP411 is a strong suppressor of the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

(Bilen and Bonini, 2007)

The addition of DnaJ-1^EP411 to Hsap\ATX1^82Q.Scer\UAS flies produces a suppression of the eye phenotype, revealing less disrupted ommatidia and improved retinal thickness.

(Fernandez-Funez et al., 2000)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33805

P{GawB}elav^C155; P{EP}DnaJ-1^EP411

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

DnaJ-1^EP411

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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