FlyBase Allele Report: Dmel\CG14207[EP1348]

General Information

Symbol

Dmel\CG14207^EP1348

Species

D. melanogaster

Name

FlyBase ID

FBal0267714

Feature type

allele

Associated gene

Dmel\CG14207

Associated Insertion(s)

P{EP}CG14207^EP1348

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gregory et al., 2012)

Progenitor genotype

Associated Insertion(s)

P{EP}CG14207^EP1348

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:19,605,153..19,605,153 [+]

(Gregory et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Bilen and Bonini, 2007)

ameliorates neurodegenerative disease

modeled by Hsap\TARDBP^UAS.Tag:HA

(Gregory et al., 2012)

modeled by Hsap\TARDBP^{TDP-25.UAS.Tag:HA}

(Gregory et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

CG14207^EP1348, Scer\GAL4^Toll-6-D42, Scer\GAL80^ts.αTub84B is a suppressor | partially of short lived phenotype of Hsap\TARDBP^UAS.Tag:HA, Scer\GAL4^Toll-6-D42, Scer\GAL80^ts.αTub84B

(Gregory et al., 2012)

CG14207^EP1348, Scer\GAL4^Toll-6-D42, Scer\GAL80^ts.αTub84B is a suppressor | partially of abnormal locomotor behavior phenotype of Hsap\TARDBP^UAS.Tag:HA, Scer\GAL4^Toll-6-D42, Scer\GAL80^ts.αTub84B

(Gregory et al., 2012)

CG14207^EP1348, Scer\GAL4^Toll-6-D42, Scer\GAL80^ts.αTub84B is a suppressor of short lived phenotype of Hsap\TARDBP^{TDP-25.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42, Scer\GAL80^ts.αTub84B

(Gregory et al., 2012)

CG14207^EP1348, Scer\GAL4^Toll-6-D42, Scer\GAL80^ts.αTub84B is a suppressor of abnormal locomotor behavior phenotype of Hsap\TARDBP^{TDP-25.UAS.Tag:HA}, Scer\GAL4^Toll-6-D42, Scer\GAL80^ts.αTub84B

(Gregory et al., 2012)

CG14207^EP1348, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

CG14207^EP1348, Scer\GAL4^GMR.PU is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

CG14207^EP1348 is a suppressor of abnormal phototaxis | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

CG14207^EP1348 is a suppressor | partially of abnormal phototaxis | adult stage phenotype of Hsap\ATXN3^{fl.Q84.UAS.Tag:MYC}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

CG14207^EP1348, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

CG14207^EP1348, Scer\GAL4^GMR.long is a suppressor | partially of ommatidium phenotype of Hsap\TARDBP^UAS.Tag:HA, Scer\GAL4^GMR.long

(Gregory et al., 2012)

CG14207^EP1348, Scer\GAL4^GMR.long is a suppressor of ommatidium phenotype of Hsap\TARDBP^{TDP-25.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Gregory et al., 2012)

CG14207^EP1348/Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Hsap\TARDBP^{TDP-25.UAS.Tag:HA}, Scer\GAL4^GMR.long

(Gregory et al., 2012)

CG14207^EP1348, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

CG14207^EP1348, Scer\GAL4^GMR.PU is a suppressor of retina phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

CG14207^EP1348, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\HSPA1L^K71E.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Overexpression of CG14207^EP1348 under the control of Scer\GAL4^GMR.long partially suppresses the ommatidium phenotype caused by Hsap\TARDBP^{Scer\UAS.T:Ivir\HA1} expression.

Overexpression of CG14207^EP1348 under the control of Scer\GAL4^GMR.long completely suppresses the ommatidium phenotype caused by Hsap\TARDBP^{TDP-25.Scer\UAS.T:Ivir\HA1} expression.

Overexpression of CG14207^EP1348 under the control of Scer\GAL4^GMR.PF completely suppresses the ommatidium phenotype caused by Hsap\TARDBP^{TDP-25.Scer\UAS.T:Ivir\HA1} expression.

Overexpression of CG14207^EP1348 at the permissive temperature under the control of both Scer\GAL4^D42 and Scer\GAL80^ts.αTub84B partially suppresses the shortened lifespan phenotype caused by Hsap\TARDBP^{Scer\UAS.T:Ivir\HA1} expression alone.

Overexpression of CG14207^EP1348 at the permissive temperature under the control of both Scer\GAL4^D42 and Scer\GAL80^ts.αTub84B completely suppresses the shortened lifespan phenotype caused by Hsap\TARDBP^{TDP-25.Scer\UAS.T:Ivir\HA1} expression alone.

Overexpression of CG14207^EP1348 at the permissive temperature under the control of both Scer\GAL4^D42 and Scer\GAL80^ts.αTub84B completely suppresses the locomotor defects caused by Hsap\TARDBP^{TDP-25.Scer\UAS.T:Ivir\HA1} expression alone.

Overexpression of CG14207^EP1348 at the permissive temperature under the control of both Scer\GAL4^D42 and Scer\GAL80^ts.αTub84B partially suppresses the locomotor defects caused by Hsap\TARDBP^{Scer\UAS.T:Ivir\HA1} expression alone.

(Gregory et al., 2012)

CG14207^EP1348 is a strong suppressor of the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU. External eye pigmentation is restored, and the thickness of the retina is restored towards normal.

Co-expression of CG14207^EP1348 partially restores visual behaviour in 1 day old flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU and tested in a phototaxis assay.

Co-expression of CG14207^EP1348 strongly suppresses the defects in phototaxis seen in 7 day old flies expressing Hsap\ATXN3^{fl.Q84.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PU.

(Bilen and Bonini, 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CG14207^EP1348

(Bilen and Bonini, 2007)

Name Synonyms

Secondary FlyBase IDs

References (2)

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