FlyBase Allele Report: Dmel\Myc[dm-1]

General Information

Symbol

Dmel\Myc^dm-1

Species

D. melanogaster

Name

FlyBase ID

FBal0002702

Feature type

allele

Associated gene

Dmel\Myc

Associated Insertion(s)

gypsy{}Myc^dm-1

Carried in Construct

Also Known As

dm¹

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Johnston et al., 1999)

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

gypsy{}Myc^dm-1

Cytology

Description

gypsy is inserted into the first intron 418 nucleotides upstream of the translation initiation site, within a six-nucleotide sequence identical to other known gypsy insertion sites.

(Gallant et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:3,374,588..3,374,588 [+]

(Johnston et al., 1999, Gallant et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | female (with Myc²)

(Maines et al., 2004)

decreased body size | female (with Myc³)

(Maines et al., 2004)

decreased body size | female | recessive

(Moberg et al., 2004)

decreased body size | male | recessive

(Moberg et al., 2004)

decreased cell number | recessive

(Moberg et al., 2004)

female sterile

(Johnston et al., 1999)

female sterile (with Myc²)

(Maines et al., 2004)

female sterile (with Myc³)

(Maines et al., 2004)

female sterile (with Myc^PG45)

(Moberg et al., 2004)

female sterile | recessive

(Moberg et al., 2004, Gallant et al., 1996)

lethal | female limited

(Kappes et al., 2011)

visible

(Johnston et al., 1999, Schreiber-Agus et al., 1997)

visible | recessive

(Gallant et al., 1996)

Phenotype Manifest In

follicle cell

(Gallant et al., 1996)

germline cell

(Gallant et al., 1996)

macrochaeta

(Schreiber-Agus et al., 1997)

macrochaeta | female (with Myc²)

(Maines et al., 2004)

macrochaeta | female (with Myc³)

(Maines et al., 2004)

microchaeta

(Schreiber-Agus et al., 1997)

Detailed Description

Statement

Reference

Approximately 6% of dm¹ homozygous females survive to adulthood, compared with 85% of sibling dm¹/Y males.

(Kappes et al., 2011)

dm¹/dm² and dm¹/dm³ females are small with slender bristles and are sterile.

(Maines et al., 2004)

Homozygous females and hemizygous males smaller than wild-type flies. The hair density in dm¹ wings is the same, indicating that the cells are of comparable size, indicating that dm¹ wings are smaller than wild-type wings because they contain fewer cells. dm¹/dm^PG45 females produce eggs with a 2-3% hatching rate.

(Moberg et al., 2004)

Overt small and slender bristles and body. Mutant flies carrying dm^{Scer\UAS.cSAa} under the control of Scer\GAL4^sca-537.4 demonstrate a marked increase in the size of the micro- and macrochaetae of the adult cuticle. Mutant flies carrying dm^hs.PSA also exhibit rescue of the bristle and body size.

(Schreiber-Agus et al., 1997)

Germ cells and follicle cells are defective, failing to migrate and undergo the transition to columnar epithelium.

(Gallant et al., 1996)

Bristles and body small and slender. Viability excellent. Females sterile. Oocyte cyst development abnormal; nurse-cell nuclei swell in stage 7, subsequently becoming pycnotic (King and Burnett, 1957); cuboidal follicle cells covering developing oocyte in stage 8 fail to show normal growth and degenerate rather than becoming columnar (King and Vanoucek, 1960). Chambers degenerate around stage 8; phenotype of homozygous dm less severe than that of dm hemizygous with dm^- deficiency (King and Vanoucek, 1960). RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Myc^dm-1 has lethal | female limited phenotype, suppressible by sisA^unspecified

(Kappes et al., 2011)

Myc^dm-1 has lethal | female limited phenotype, suppressible by sc^sisB-1

(Kappes et al., 2011)

Myc^dm-1 has lethal | female limited phenotype, suppressible by run³

(Kappes et al., 2011)

Myc^dm-1 has decreased body size | recessive phenotype, suppressible by ago[+]/ago¹

(Moberg et al., 2004)

Myc^dm-1 has decreased body size | recessive | female phenotype, suppressible by ago[+]/ago¹

(Moberg et al., 2004)

Myc^dm-1 has female sterile | recessive phenotype, suppressible by ago[+]/ago¹

(Moberg et al., 2004)

Myc^dm-1 has decreased cell number | recessive phenotype, suppressible by ago[+]/ago¹

(Moberg et al., 2004)

Enhancer of

Statement

Reference

Myc^dm-1/Myc[+] is an enhancer of decreased size | adult stage | somatic clone - tissue specific phenotype of Kdm5^I1, hid^GMR.PG

(Herz and Bergmann, 2024)

Myc^dm-1/Myc[+] is an enhancer of visible | adult stage | somatic clone - tissue specific phenotype of Kdm5^I1, hid^GMR.PG

(Herz and Bergmann, 2024)

Suppressor of

Statement

Reference

Myc^dm-1 is a suppressor | partially of viable phenotype of Sxl^N.Hsp83.lacZ, Sxl^fP7B0

(Kappes et al., 2011)

Myc^dm-1 is a suppressor of viable phenotype of Sxl^fP7B0

(Kappes et al., 2011)

Myc^dm-1/dm[+] is a suppressor of visible | dominant phenotype of N^55e11

(Orian et al., 2007)

Myc^dm-1 is a suppressor of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

NOT Suppressor of

Statement

Reference

Myc^dm-1/Myc[+] is a non-suppressor of visible | adult stage phenotype of hid^GMR.PG

(Herz and Bergmann, 2024)

Myc^dm-1/Myc[+] is a non-suppressor of decreased size | adult stage phenotype of hid^GMR.PG

(Herz and Bergmann, 2024)

Other

Statement

Reference

Egfr^f2, Myc^dm-1/dm[+] has lethal | dominant | maternal effect | embryonic stage phenotype

(Orian et al., 2007)

Egfr^f2, Myc^dm-1/dm[+] has abnormal neuroanatomy | dominant | embryonic stage phenotype

(Orian et al., 2007)

H^UAS.cMa, Myc^dm-1, Scer\GAL4^GMR.PF has lethal phenotype

(Müller et al., 2005)

Phenotype Manifest In

Suppressed by

Statement

Reference

Myc^dm-1 has phenotype, suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

Myc^dm-1/Myc[+] is an enhancer of eye | somatic clone - tissue specific phenotype of Kdm5^I1, hid^GMR.PG

(Herz and Bergmann, 2024)

Suppressor of

Statement

Reference

Myc^dm-1/dm[+] is a suppressor of chaeta | ectopic phenotype of N^55e11

(Orian et al., 2007)

Myc^dm-1 is a suppressor of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

NOT Suppressor of

Statement

Reference

Myc^dm-1/Myc[+] is a non-suppressor of eye phenotype of hid^GMR.PG

(Herz and Bergmann, 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Approximately 76% of sisA^unspecified dm¹ trans-heterozygous female offspring from dm¹ fathers mated to sisA^unspecified females survive.

Approximately 24% of sc^sisB-1 dm¹ trans-heterozygous female offspring from dm¹ fathers mated to sc^sisB-1 females survive.

All run³ dm¹ trans-heterozygous female offspring from dm¹ fathers mated to run³ females survive.

Females trans-heterozygous for Sxl^fP7B0 and dm¹ are approximately two-thirds as viable as their dm¹/+ siblings.

Sxl^{N.Hsp83.T:Ecol\lacZ} females that are trans-heterozygous for Sxl^fP7B0 and dm¹ are two-thirds as viable as their Sxl^{N.Hsp83.T:Ecol\lacZ} Sxl^fP7B0/+ sisters.

(Kappes et al., 2011)

More than 90% of dm¹/+ ; Egfr^f2/+ embryos show severe defects in the nervous system at stage 17.

The ectopic bristle phenotype seen in N^55e11/+ females is partially suppressed if they are also heterozygous for dm¹.

(Orian et al., 2007)

Heterozygosity for ago¹ increase the female body length of dm¹ flies by about 12%. The wings of dm¹ ; ago¹/+ adults are about 15% larger than those of dm¹ adults. This suppression is due to an increase in the number of cells. dm¹ ; ago¹/+ females lay eggs that can give rise to viable larvae.

(Moberg et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Myc^dm-1 is rescued by Myc^UAS.cSAa/Scer\GAL4^sca-537.4

(Schreiber-Agus et al., 1997)

Myc^dm-1 is rescued by Myc^hs.PSA

(Schreiber-Agus et al., 1997)

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (11)

Kyoto

105685

Myc^dm-1/C(1)DX, y¹ f¹

101072

Df(1)N71 / FM6, y^31d sc⁸ Myc^dm-1 Bar¹

101120

In(1LR)pn2b / FM6, y^31d sc⁸ Myc^dm-1 Bar¹

101097

FM6, y^31d sc⁸ Myc^dm-1 Bar¹ / qs¹

101099

FM6, y^31d sc⁸ Myc^dm-1 Bar¹ / shakB⁶

101100

FM6, y^31d sc⁸ Myc^dm-1 Bar¹ / stnA¹⁵

101089

eor¹ / FM6, y² sc⁸ Myc^dm-1 Bar¹ / Dp(1;Y)y⁺mal¹²⁶

107651

y¹ ac^Hw-1 Myc^dm-1 lz¹; su(Hw)² Sb^sbd-2/TM6, su(Hw)⁵

101102

FM6, y^31d sc⁸ Myc^dm-1 Bar¹ / w¹ fliI¹⁴ / Dp(1;Y)mal⁺

101098

FM6, y^31d sc⁸ Myc^dm-1 Bar¹ / Npc1b^LB2 / Dp(1;Y)y⁺mal¹⁰⁶

103247

FM6, y^31d sc⁸ Myc^dm-1 Bar¹ / y¹ ac¹ sc¹ pn¹ w¹ rb¹ cm¹ ct¹ sn³ ras⁴ v¹ m¹ g¹ f¹ car¹

Notes on Origin

Discoverer

Comments

Alleles can be ranked in a phenotypic series. Going from weakest to strongest phenotype: dm¹ < dm^P0 < dm^P1.

(Johnston et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

(Mukherjee et al., 2006)

Myc¹

Myc^dm-1

(Pan et al., 2022)

Myc^dm1

(Gamberi et al., 2017)

dMyc¹

(Herz and Bergmann, 2024)

dm¹

(Ribot et al., 2022, Fernando et al., 2015, Kappes et al., 2011, Christensen et al., 2009.7.21, Christensen et al., 2008.6.11, Orian et al., 2007)

dmyc^dm1

(Johnston et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (22)

Report Sections

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