FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sisAunspecified
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General Information
Symbol
Dmel\sisAunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0062466
Feature type
allele
Associated gene
Dmel\sisA
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Male mutant embryos have a gap between the yolk cells and the adjacent soma. This defect is first seen in stage 8 embryos and persists in later stages. Some of the embryos arrest late in germband retraction, while others develop a wide range of cuticular and internal structures, occasionally nearly completing development. The yolk mass often contains large globular yolk droplets.

        (Walker et al., 2000)

        sisAunspecified In(2LR)Scorv1LTE35B-4R double heterozygous females have reduced viability at 29oC.

        (Sanchez et al., 1994)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        sisAunspecified is a suppressor of lethal | female limited phenotype of Mycdm-1

        (Kappes et al., 2011)

        sisAunspecified is a suppressor of lethal | female limited phenotype of MycP0

        (Kappes et al., 2011)

        sisAunspecified is a suppressor of lethal | female limited phenotype of MycP1

        (Kappes et al., 2011)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Approximately 76% of sisAunspecified dm1 trans-heterozygous female offspring from dm1 fathers mated to sisAunspecified females survive.

        Approximately 88% of sisAunspecified dmP0 trans-heterozygous female offspring from dmP0 fathers mated to sisAunspecified mothers survive.

        Approximately 84% of sisAunspecified dmP1 trans-heterozygous female offspring from dmP1 fathers mated to sisAunspecified mothers survive.

        (Kappes et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        sisA
        (Kappes et al., 2011)
        sisAunspecified
        unspecified
        (Sanchez et al., 1994)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)