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FB2026_02
,
released June 18, 2026
sis-a, sis a
Please see the JBrowse view of Dmel\sisA for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
0.8 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
189 (aa); 21 (kD predicted)
Homodimer. Interacts with dpn (via bHLH motif). Interacts with da (via bHLH motif). Interacts with Bap60.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sisA using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
sisA transcripts are detected in embryos from 0-12 hours but not at later stages of development. Transcripts are not detected in adult females indicating that the transcripts present in 0-2hr embryos are of zygotic origin. sisA transcripts are first detected at the end of the eighth nuclear cycle. Initially all nuclei express sisA but expression is extinguished in the prepole cell nuclei. Transcripts are closely associated with the somatic and yolk nuclei through cycle 10 after which they are distributed fairly uniformly in the somatic portion of the embryo and are no longer associated with nuclei. Transcript levels peak in late cycle 12 and cycle 13 and decay rapidly thereafter. In contrast to the somatic nuclei, the yolk nuclei accumulate high levels of sisA transcripts from cycle 8 until they degenerate ~10-11 hours after fertilization.
JBrowse - Visual display of RNA-Seq signals
View Dmel\sisA in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
In the absence of sisA function, endoderm migration and midgut formation are blocked in the embryo.
sisA has an essential function in the yolk nuclei of both sexes.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
An increased sisA and sc dose equivalent to that in females causes male lethal effects and cannot activate the construct P{SxlPe-lacZ}, which carries the embryonic promoter of Sxl, to the female expression level in all tissues. Male lethality can be completely suppressed by a Sxl null mutation.
Mutations in zygotic gene sisA interact with RpII140wimp.
sisA/Df(1)HC244 females are fully fertile.
Source for identity of: sisA CG1641