FlyBase Allele Report: Dmel\S[IIN]

Homozygous S^IIN mutant third instar larva eye discs show misrotated ommatidia and missing photoreceptors. Photoreceptor axons are correctly targeted to the lamina, but defects in lamina cartridge neuron differentiation are seen. Only a small number of cells in the posterior lamina appear to have differentiated correctly.

(Yogev et al., 2010)

In S^IIN stage 15 embryos, the genital disc precursor cells are completely missing.

(Chen et al., 2005)

Homozygous embryos have a reduced number of midline glia per ventral nerve cord segment compared to wild type. The embryos have breaks in the dorsal trunk of the tracheal system at stage 15.

(Sonnenfeld et al., 2004)

No increase is seen in cardioblast numbers in the developing embryo.

(Alvarez et al., 2003)

S^IIN embryos have an average of 3.04 +/- 0.2 neurons per lch5 organ.

(Rusten et al., 2001)

Homozygous female germline clones do not develop beyond stage 1 of oogenesis.

(Ruden et al., 1999)

Homozygous embryos lack many myofibres.

(Buff et al., 1998)

Homozygous embryos have a reduced number of cells in both the anterior and posterior Malpighian tubules compared to wild-type embryos. The number of cells in the anterior Malpighian tubules is severely reduced in rho^7M43 S^IIN double mutant embryos.

(Kerber et al., 1998)

Early CNS development is essentially normal in mutant embryos.

(Skeath, 1998)

The central nervous system (CNS) is narrower than normal and the commissures are thicker than normal and incompletely separated in S^IIN embryos.

(Dong and Jacobs, 1997)

S¹/S^IIN embryos exhibit deletion of the ventral denticles and Keilin's organs are missing or defective. Wing, leg, haltere and eye/antenna S¹/S^IIN mutant discs can be in vivo cultured.

(Simcox, 1997)

Mutant embryos exhibit tracheal phenotype.

(Wappner et al., 1997)

Nondefective in gonad assembly.

(Warrior, 1994)

All or nearly all of the ventral epidermal cells are absent in mutant embryos.

(Kim and Crews, 1993)

No changes in phenotype of tor^13D embryos.

(Strecker et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

S[+]/S^IIN is a suppressor of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

S^IIN is a suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

S^IIN is a suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

S[+]/S^IIN is a suppressor of abnormal planar polarity | recessive phenotype of sl⁹

(Schlesinger et al., 2004)

Other

Statement

Reference

Df(2R)ST1/+, S^IIN has abnormal neuroanatomy | dominant phenotype

(Sonnenfeld et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

S^IIN has photoreceptor neuron phenotype, enhanceable by step[+]/step^k08110

(Hahn et al., 2013)

Egfr^f1, S^IIN has somatic muscle cell | embryonic stage phenotype, enhanceable by spi¹

(Buff et al., 1998)

NOT Enhanced by

Statement

Reference

S^IIN has photoreceptor neuron phenotype, non-enhanceable by InR[+]/InR⁰⁵⁵⁴⁵

(Hahn et al., 2013)

S^IIN has phenotype, non-enhanceable by rho^hs.PSt

(Lanoue and Jacobs, 1999)

Suppressed by

Statement

Reference

S^IIN has larval ventral nerve cord phenotype, suppressible by Df(3L)H99

(Dong and Jacobs, 1997)

NOT suppressed by

Statement

Reference

S^IIN has photoreceptor neuron phenotype, non-suppressible by InR[+]/InR⁰⁵⁵⁴⁵

(Hahn et al., 2013)

S^IIN has larval ventral midline glial cell phenotype, non-suppressible by jing^UAS.cSa/Scer\GAL4^sli.PS

(Sonnenfeld et al., 2004)

S^IIN has phenotype, non-suppressible by rho^hs.PSt

(Lanoue and Jacobs, 1999)

Enhancer of

Statement

Reference

S^IIN is an enhancer of eye phenotype of DCTN1-p150^Gl-1

(Iyadurai et al., 2008)

S[+]/S^IIN is an enhancer of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PU

(Protzer et al., 2008)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 2 dorsal acute muscle 1 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 3 dorsal acute muscle 1 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 6 ventral acute muscle 2 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 7 ventral acute muscle 2 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

S^IIN is an enhancer of somatic muscle cell | embryonic stage phenotype of Egfr^f1

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of somatic muscle cell | embryonic stage phenotype of Egfr^f1, spi¹

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 4 dorsal acute muscle 1 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 5 dorsal acute muscle 1 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 6 dorsal acute muscle 1 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 7 dorsal acute muscle 1 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 2 ventral acute muscle 2 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 3 ventral acute muscle 2 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 4 ventral acute muscle 2 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

S[+]/S^IIN is an enhancer of muscle cell of abdominal 5 ventral acute muscle 2 phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^how-24B, Scer\GAL4^twi.PG

(Buff et al., 1998)

NOT Enhancer of

Statement

Reference

S^IIN is a non-enhancer of cephalopharyngeal skeleton phenotype of Krn^UAS.cRa, Scer\GAL4^69B

(Reich and Shilo, 2002)

S^IIN is a non-enhancer of wing phenotype of Krn^UAS.cRa, Scer\GAL4^Bx-MS1096

(Reich and Shilo, 2002)

S^IIN is a non-enhancer of eye phenotype of N^spl-1

(Nagel and Preiss, 1999)

Suppressor of

Statement

Reference

S^IIN, Scer\GAL4^Tub.PU is a suppressor of wing vein phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

S^IIN, Scer\GAL4^Tub.PU is a suppressor of eye phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

S^IIN, Scer\GAL4^Tub.PU is a suppressor of ommatidium phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

S^IIN, Scer\GAL4^Tub.PU is a suppressor of photoreceptor cell R7 | ectopic phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

S[+]/S^IIN is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

S^IIN is a suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

S^IIN is a suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

S[+]/S^IIN is a suppressor | partially of photoreceptor cell R7 | increased number phenotype of sl⁹

(Schlesinger et al., 2004)

S[+]/S^IIN is a suppressor | partially of ommatidium phenotype of sl⁹

(Schlesinger et al., 2004)

S[+]/S^IIN is a suppressor of interommatidial bristle phenotype of sl⁹

(Schlesinger et al., 2004)

S^IIN/S^IIN is a suppressor of larval ventral midline glial cell | ectopic phenotype of Scer\GAL4^sli.PS, jing^UAS.cSa

(Sonnenfeld et al., 2004)

S[+]/S^IIN is a suppressor of phenotype of Src42A^Su(Raf)1-1

(Zhang et al., 1999)

S^IIN is a suppressor of larval dorsal hair phenotype of Scer\GAL4^55B, rho^UAS.cGa

(Sapir et al., 1998)

S^IIN is a suppressor of dorsal appendage phenotype of Scer\GAL4^55B, rho^UAS.cGa

(Sapir et al., 1998)

S^IIN is a suppressor of ventral denticle belt phenotype of Scer\GAL4^55B, rho^UAS.cGa

(Sapir et al., 1998)

NOT Suppressor of

Statement

Reference

S[+]/S^IIN is a non-suppressor of larval ventral midline glial cell | ectopic phenotype of Scer\GAL4^sli.PS, jing^UAS.cSa

(Sonnenfeld et al., 2004)

S^IIN is a non-suppressor of cephalopharyngeal skeleton phenotype of Krn^UAS.cRa, Scer\GAL4^69B

(Reich and Shilo, 2002)

S^IIN is a non-suppressor of wing phenotype of Krn^UAS.cRa, Scer\GAL4^Bx-MS1096

(Reich and Shilo, 2002)

Other

Statement

Reference

Df(2R)ST1/+, S^IIN has larval ventral midline glial cell phenotype

(Sonnenfeld et al., 2004)

S^IIN, jing[+]/jing⁰¹⁰⁹⁴ has embryonic/larval tracheal dorsal trunk phenotype

(Sonnenfeld et al., 2004)

S^IIN, jing[+]/jing³ has embryonic/larval tracheal dorsal trunk phenotype

(Sonnenfeld et al., 2004)

S^IIN, jing⁰¹⁰⁹⁴ has embryonic/larval tracheal dorsal trunk phenotype

(Sonnenfeld et al., 2004)

S^IIN, jing³ has embryonic/larval tracheal dorsal trunk phenotype

(Sonnenfeld et al., 2004)

Ras85D^N17.sev, S^IIN has photoreceptor cell R7 phenotype

(Ruden et al., 1999)

Raf¹², S^IIN has photoreceptor cell R7 phenotype

(Ruden et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

S^IIN/step^k08110 trans-heterozygotes exhibit a photoreceptor differentiation phenotype, increased in severity from S^IIN heterozygotes.

S^IIN/+;InR⁰⁵⁵⁴⁵/+ flies do not exhibit an enhanced photoreceptor differentiation phenotype compared to S^IIN heterozygotes.

(Hahn et al., 2013)

The presence of a S^IIN background significantly suppresses ectopic wing vein formation found in csw^{Y279C.Scer\UAS} (Scer\GAL4^tub) mutants.

A S^IIN background suppresses the csw^{Y279C.Scer\UAS} (Scer\GAL4^tub) rough eye phenotype, normalizing the numbers of R7 and ommatidial rotation.

(Oishi et al., 2009)

The small-eye phenotype observed in animals expressing H^Scer\UAS.cMa in the eye under the control of Scer\GAL4^GMR.PU is enhanced in a S^IIN/+ background.

(Protzer et al., 2008)

The increase in the number of midline glia per ventral nerve cord segment seen in embryos expressing jing^Scer\UAS.cSa under the control of Scer\GAL4^sli.PS is not suppressed by S^IIN, but expression of jing^Scer\UAS.cSa under the control of Scer\GAL4^sli.PS in a homozygous S^IIN background does not induce extra midline glia and the number of midline glia per ventral nerve cord segment in these double mutant embryos is reduced compared to wild type and is similar to that seen in homozygous S^IIN single mutants. S^IIN/Df(2R)ST1 double heterozygous embryos have a reduced number of midline glia per segment compared to wild type. S^IIN/jing³ and S^IIN/jing⁰¹⁰⁹⁴ double heterozygous embryos have breaks in the dorsal trunk of the tracheal system at stage 15.

(Sonnenfeld et al., 2004)

salm³ S^IIN double mutant embryos have an average of 3.05 +/- 0.20 neurons per lch5 organ, similar to S^IIN single mutant embryos. The embryos show misplacement of the lch5 organ along the dorsoventral axis comparable to the phenotype seen in salm single mutants.

(Rusten et al., 2001)

The ubiquitous expression of rho^hs.PSt under heatshock has no effect on S^IIN embryos.

(Lanoue and Jacobs, 1999)

Has no effect on the eye phenotype of N^spl-1.

(Nagel and Preiss, 1999)

Flies doubly mutant for S^IIN and either phl¹² or Ras85D^N17.sev have no R7 photoreceptor cells.

(Ruden et al., 1999)

Dominantly suppresses the ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies.

(Zhang et al., 1999)

Embryos expressing Egfr^{DN.Scer\UAS.cBa} under the control of both Scer\GAL4^twi.PG and Scer\GAL4^how-24B show a partial reduction in the development of muscles DA1 and VA2. This phenotype is dominantly enhanced by S^IIN. Dominantly enhances the mild muscle phenotype of Egfr^f1 embryos raised at 18^oC. Further enhancement of the phenotype is also seen if the flies are also heterozygous for spi¹.

(Buff et al., 1998)

Germline clones fail to rescue the female sterile phenotype of Fs(2)Ugr.

(Sapir et al., 1998)

The width of the CNS is closer to wild-type if S^IIN embryos are also mutant for Df(3L)H99, although commissure separation remains incomplete.

(Dong and Jacobs, 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

S^rK134

(Iyadurai et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

2772

S^IIN cn¹ bw¹ speck¹/CyO

Kyoto

107464

S^IIN cn¹ bw¹ speck¹/CyO

Notes on Origin

Discoverer

Comments

Less than 10% of wild type number of ventral epidermal cells expressing P{lacZ}BP28 are evident in mutant embryos. oc expression is greatly reduced along the midline.

(Kim and Crews, 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

S^11N23

(Shamloula et al., 2002, Kolodkin et al., 1994)

S^II

(Warrior, 1994)

S^IIN23

(Yogev et al., 2010, Chen et al., 2005, Sonnenfeld et al., 2004, Reich and Shilo, 2002, Lanoue and Jacobs, 1999, Nagel and Preiss, 1999, Zhang et al., 1999, Kerber et al., 1998, Sapir et al., 1998, Dong and Jacobs, 1997, Stemerdink and Jacobs, 1997, Wappner et al., 1997, Golembo et al., 1996, Schweitzer et al., 1995, Raz and Shilo, 1993, Strecker et al., 1991)

S^IIN

(Zhu et al., 2017, Huh et al., 2009, Oishi et al., 2009, Iyadurai et al., 2008, Kim et al., 2007, Maeda et al., 2007, Oishi et al., 2006)

Star^IIN23

(Schlesinger et al., 2004)

Star^IIN

(Protzer et al., 2008, Skeath, 1998)

star^IIN

(Liu et al., 2010)

Name Synonyms

StarIIN

(Hahn et al., 2013)

Secondary FlyBase IDs

References (43)

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