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General Information
Symbol
Dmel\sl9
Species
D. melanogaster
Name
FlyBase ID
FBal0151485
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G16350746A

Reported nucleotide change:

G?A

Amino acid change:

W54term | sl-PA

Reported amino acid change:

W54term

Comment:

TGG to TAG

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G?A.

Amino acid replacement: W54term.

Amino acid replacement: ?54term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Wing blade area is reduced by approximately 20% in homozygous sl9 mutant males compared to wild type. The area of the eye is also reduced by about 8% compared to controls. sl9 mutant flies also show a 9% reduction in the number of ommatidia (sl9 mutant eyes have on average 698 ommatidia compared to 765 in wild type). sl9 mutant eyes have an increased number of R7 photoreceptors per ommatidium, but the combined area of the R1-R6 rhabdomeres is reduced by on average 15.2% compared to heterozygous controls indicating a reduced cell size.

Two day old homozygous sl9 mutant females are approximately 8% lighter than their heterozygous siblings. Pupal length and weight of stage 12-15 pupae do not differ from controls.

In the eyes of sl9 homozygous flies, ~9% of ommatidia are misrotated and over half have between one and three extra R7 cells extra photoreceptors. In addition, interommatidial bristles are sometimes misplaced or supernumerary.

58.9% of ommatidia have extra R7 cells in homozygous females. The length of the wing is approximately 80% normal length in homozygous females, and ectopic wing veins are seen. sl8/sl9 and sl7/sl9 females have wing lengths indistinguishable from each other and typical of sl mutant homozygotes. sl8/sl9 females have extra R7 cells in 45.9% of ommatidia. sl7/sl9 females have extra R7 cells in 7.8% of ommatidia.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

sl9 has increased cell number | adult stage phenotype, enhanceable by ItprB4/Itp-r83A[+]

sl9 has abnormal planar polarity | recessive phenotype, enhanceable by aosΔ7/argos[+]

NOT Enhanced by
Statement
Reference

sl9 has abnormal size | adult stage phenotype, non-enhanceable by Egfr[+]/Egfrf2

sl9 has abnormal size | adult stage phenotype, non-enhanceable by drk[+]/drke0A/drke0A

sl9 has abnormal size | adult stage phenotype, non-enhanceable by ItprB4/Itp-r83A[+]

sl9 has abnormal size | adult stage phenotype, non-enhanceable by InR[+]/InRE19

sl9 has abnormal size | adult stage phenotype, non-enhanceable by Akt1[+]/Akt1

Suppressed by
Statement
Reference

sl9 has abnormal planar polarity | recessive phenotype, suppressible by S[+]/SIIN

Suppressor of
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

sl9 has photoreceptor cell R7 | adult stage phenotype, enhanceable by ItprB4/Itp-r83A[+]

sl9 has ommatidium phenotype, enhanceable by aosΔ7/argos[+]

sl9 has interommatidial bristle phenotype, enhanceable by aosΔ7/argos[+]

NOT Enhanced by
Statement
Reference

sl9 has wing blade phenotype, non-enhanceable by Egfr[+]/Egfrf2

sl9 has wing blade phenotype, non-enhanceable by drk[+]/drke0A/drke0A

sl9 has wing blade phenotype, non-enhanceable by ItprB4/Itp-r83A[+]

sl9 has wing blade phenotype, non-enhanceable by InR[+]/InRE19

sl9 has wing blade phenotype, non-enhanceable by Akt1[+]/Akt1

Suppressed by
Statement
Reference

sl9 has ommatidium phenotype, suppressible | partially by Egfr[+]/Egfrf2

sl9 has interommatidial bristle phenotype, suppressible by Egfr[+]/Egfrf2

sl9 has ommatidium phenotype, suppressible | partially by S[+]/SIIN

sl9 has interommatidial bristle phenotype, suppressible by S[+]/SIIN

Suppressor of
Statement
Reference

sl9/sl9 is a suppressor | partially of ommatidium phenotype of ruPLLb

Additional Comments
Genetic Interactions
Statement
Reference

One copy of InRE19 does not enhance the reduction in wing blade area seen in homozygous sl9 males.

One copy of Akt11 does not enhance the reduction in wing blade area seen in homozygous sl9 males.

One copy of Egfrf2 does not enhance the reduction in wing blade area seen in homozygous sl9 males.

One copy of drke0A does not enhance the reduction in wing blade area seen in homozygous sl9 males.

One copy of Itp-r83AB4 does not enhance the reduction in wing blade area seen in homozygous sl9 males.

One copy of InR93Dj-4 does not enhance the increase in R7 photoreceptor cells per ommatidium that is seen in sl9 mutant males.

One copy of Itp-r83AB4 enhances the percentage of sl9 mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also increased.

Misrotation of ommatidia and extra R7 photoreceptor due to sl9/sl9 are almost completely suppressed by SIIN/+ or Egfrf2/+, but are enhanced by argosΔ7/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Rescued by
Partially rescued by
Comments

slScer\UAS.cSa; Scer\GAL4sca-537.4 largely rescues the eye phenotypes seen in sl9/sl9 homozygotes: most ommatidia have normal numbers of photoreceptor cells and only a small proportion have rotation defects.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)