Open Close
General Information
Symbol
Dmel\sl1
Species
D. melanogaster
Name
FlyBase ID
FBal0015677
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
transposable element insertion site
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

7.5kb insertion of 412 3' to nucleotide 3121 of FBrf0073038, in the PH domain.

Insertion components
412{}sl1
Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

sl1 mutant ommatidia contain an increased number of R7 photoreceptors per ommatidium compared to wild type.

Germaria mutant for sl1 do not exhibit ectopic spectrosome containing cells.

sl1 homozygotes have a mild eye phenotype: ommatidial organization in to ordered rows is slightly disrupted, interommatidial bristle location is abnormal and ~25% of ommatidia are mis-rotated.

Light responses in mutant photoreceptors have essentially wild-type properties.

Border cell migration is normal in sl1/sl2 mutants.

Supernumerary R7 phenotype in approximately 30% of ommatidia. The phenotype is similar to that of Gap1 mutations, but less severe.

Homozygotes show a modest reduction in wing length and a mildly rough eye. In addition, homozygotes show ectopic wing veins, most frequently adjacent to L2 but sometimes connected or adjacent to the posterior crossvein or in the posterior cell. Ommatidial array is disrupted, many ommatidia are abnormally shaped. Eyes show interommatidial bristle defects. Some are missing, some are duplicated and some appear at additional vertices. 51% of ommatidia contain extra inner photoreceptors. A small fraction of ommatidia have one or more extra (2%) or missing (10%) outer photoreceptors. The majority of supernumerary photoreceptors show an R7 identity. Homozygotes contain as many as three more cone cells than wild type, and an extra primary pigment cell is sometimes present.

Wings about 80% normal length, straight edged and blunt tipped. Crossveins rather close. Eyes large and slightly rough.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressor of
Statement
Reference

sl1 is a suppressor of visible phenotype of Pp2B-14Dact.GMR

Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference

sl1 has photoreceptor cell R7 | ectopic phenotype, suppressible by Egfr[+]/Egfrf2

sl1 has photoreceptor cell R7 | ectopic phenotype, suppressible by Egfrf3/Egfr[+]

Suppressor of
Statement
Reference

sl1 is a suppressor of eye phenotype of Pp2B-14Dact.GMR

sl1 is a suppressor of eye phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

NOT Suppressor of
Statement
Reference

sl1 is a non-suppressor of photoreceptor cell R7 phenotype of sina2

Other
Additional Comments
Genetic Interactions
Statement
Reference

One copy of InR93Dj-4 enhances the increase in R7 photoreceptor cells per ommatidium seen in sl1 mutant males.

phl11 sl1 double mutant border cell clusters (induced as clones) initiate migration, but are delayed later in posterior migration and do not show dorsal migration.

Dsor1LH110 sl1 double mutant border cell clusters (induced as clones) initiate migration, but are delayed later in posterior migration and do not show dorsal migration.

phl11 sl1 double mutant cells are generally located at the rear of the cluster during border cell late posterior migration and dorsal migration in mosaic border cell clusters consisting of both wild-type and mutant cells.

The viability of Itp-r83Awc703/Itp-r83Awc361 animals is unaffected by sl1/sl1.

In hemizygous mutants the average number of R7s is 1.3. Heterozygous Gap1B2/+ in combination with sl1 show more than 80% of ommatidia with multiple R7 cells. Average number of R7 cells per ommatidium is 2.2.

Eye supernumerary R7 cell phenotype of sl1 and sl2 is almost completely suppressed by reducing the dosage of Egfr, as in heterozygotes for Egfrf2 and Egfrf3. Double mutants of sl1 or sl2 with either sev1 or sev14 show a mutant phenotype intermediate to that of either single mutant: 35-49% of ommatidia have one R7 cell, 6-12% contain two R7 cells and the rest have no R7 cells. Double mutants with sl1 or sl2 and rl1 show phenotypes very close to that of rl1 alone. Double mutants of sl1 with sina2 show no increase in proportion of R7 cells over that seen for sina2 alone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer

Bridges, 21st Dec. 1915.

Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (14)