FlyBase Allele Report: Dmel\sl[1]

General Information

Symbol

Dmel\sl¹

Species

D. melanogaster

Name

FlyBase ID

FBal0015677

Feature type

allele

Associated gene

Dmel\sl

Associated Insertion(s)

412{}sl¹

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

loss of function allele

(Thackeray et al., 1998)

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

412{}sl¹

Cytology

Description

7.5kb insertion of 412 3' to nucleotide 3121 of FBrf0073038, in the PH domain.

(Thackeray et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:16,353,920..16,353,920

(Thackeray et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Schlesinger et al., 2004)

increased cell number | adult stage

(Murillo-Maldonado et al., 2011)

viable

(Thackeray et al., 1998)

visible | recessive

(Thackeray et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

sl¹ mutant ommatidia contain an increased number of R7 photoreceptors per ommatidium compared to wild type.

(Murillo-Maldonado et al., 2011)

Germaria mutant for sl¹ do not exhibit ectopic spectrosome containing cells.

(Liu et al., 2010)

sl¹ homozygotes have a mild eye phenotype: ommatidial organization in to ordered rows is slightly disrupted, interommatidial bristle location is abnormal and ~25% of ommatidia are mis-rotated.

(Schlesinger et al., 2004)

Light responses in mutant photoreceptors have essentially wild-type properties.

(Hardie et al., 2003)

Border cell migration is normal in sl¹/sl² mutants.

(Duchek and Rorth, 2001)

Supernumerary R7 phenotype in approximately 30% of ommatidia. The phenotype is similar to that of Gap1 mutations, but less severe.

(Powe et al., 1999)

Homozygotes show a modest reduction in wing length and a mildly rough eye. In addition, homozygotes show ectopic wing veins, most frequently adjacent to L2 but sometimes connected or adjacent to the posterior crossvein or in the posterior cell. Ommatidial array is disrupted, many ommatidia are abnormally shaped. Eyes show interommatidial bristle defects. Some are missing, some are duplicated and some appear at additional vertices. 51% of ommatidia contain extra inner photoreceptors. A small fraction of ommatidia have one or more extra (2%) or missing (10%) outer photoreceptors. The majority of supernumerary photoreceptors show an R7 identity. Homozygotes contain as many as three more cone cells than wild type, and an extra primary pigment cell is sometimes present.

(Thackeray et al., 1998)

Wings about 80% normal length, straight edged and blunt tipped. Crossveins rather close. Eyes large and slightly rough.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

sl¹ has increased cell number | adult stage phenotype, enhanceable by InR[+]/InR^93Dj-4

(Murillo-Maldonado et al., 2011)

Suppressor of

Statement

Reference

sl¹ is a suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

sl¹ is a suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

sl¹ has photoreceptor cell R7 | adult stage phenotype, enhanceable by InR[+]/InR^93Dj-4

(Murillo-Maldonado et al., 2011)

Suppressed by

Statement

Reference

sl¹ has photoreceptor cell R7 | ectopic phenotype, suppressible by Egfr[+]/Egfr^f2

(Thackeray et al., 1998)

sl¹ has photoreceptor cell R7 | ectopic phenotype, suppressible by Egfr^f3/Egfr[+]

(Thackeray et al., 1998)

Suppressor of

Statement

Reference

sl¹ is a suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

sl¹ is a suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

NOT Suppressor of

Statement

Reference

sl¹ is a non-suppressor of photoreceptor cell R7 phenotype of sina²

(Thackeray et al., 1998)

Other

Statement

Reference

Raf¹¹, sl¹ has border follicle cell | somatic clone phenotype

(Bianco et al., 2007)

Dsor1^LH110, sl¹ has border follicle cell | somatic clone phenotype

(Bianco et al., 2007)

sev¹, sl¹ has photoreceptor cell R7 phenotype

(Thackeray et al., 1998)

sev¹⁴, sl¹ has photoreceptor cell R7 phenotype

(Thackeray et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of InR^93Dj-4 enhances the increase in R7 photoreceptor cells per ommatidium seen in sl¹ mutant males.

(Murillo-Maldonado et al., 2011)

phl¹¹ sl¹ double mutant border cell clusters (induced as clones) initiate migration, but are delayed later in posterior migration and do not show dorsal migration.

Dsor1^LH110 sl¹ double mutant border cell clusters (induced as clones) initiate migration, but are delayed later in posterior migration and do not show dorsal migration.

phl¹¹ sl¹ double mutant cells are generally located at the rear of the cluster during border cell late posterior migration and dorsal migration in mosaic border cell clusters consisting of both wild-type and mutant cells.

(Bianco et al., 2007)

The viability of Itp-r83A^wc703/Itp-r83A^wc361 animals is unaffected by sl¹/sl¹.

(Banerjee et al., 2006)

In hemizygous mutants the average number of R7s is 1.3. Heterozygous Gap1^B2/+ in combination with sl¹ show more than 80% of ommatidia with multiple R7 cells. Average number of R7 cells per ommatidium is 2.2.

(Powe et al., 1999)

Eye supernumerary R7 cell phenotype of sl¹ and sl² is almost completely suppressed by reducing the dosage of Egfr, as in heterozygotes for Egfr^f2 and Egfr^f3. Double mutants of sl¹ or sl² with either sev¹ or sev¹⁴ show a mutant phenotype intermediate to that of either single mutant: 35-49% of ommatidia have one R7 cell, 6-12% contain two R7 cells and the rest have no R7 cells. Double mutants with sl¹ or sl² and rl¹ show phenotypes very close to that of rl¹ alone. Double mutants of sl¹ with sina² show no increase in proportion of R7 cells over that seen for sina² alone.