Open Close
General Information
Symbol
Dmel\sl2
Species
D. melanogaster
Name
FlyBase ID
FBal0015678
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutagen
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

13bp deletion beginning 3' of nucleotide 2027 of FBrf0073038

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

13bp deletion, beginning 3' of nucleotide 2027 of FBrf0073038, at the beginning of the first SH2 domain, which creates a stop codon beginning at nucleotide 2090.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Wing blade area is reduced by 20% in homozygous sl2 mutant males compared to wild type. This reduction can be explained by an increase in cell density as wing cells are 21% smaller than in controls but cell number is not significantly different.

sl2 mutant flies sometimes show small ectopic wing veins.

Approximately 23% of sl2 mutant ommatidia contain an increased number of R7 photoreceptors compared to wild type.

Germaria mutant for sl2 do not exhibit ectopic spectrosome containing cells.

In the eyes of sl2 homozygous flies, ~22% of ommatidia are misrotated and almost half have between one and three extra R7 cells.

Mutants have 1.253 +/- 0.038 R7 cells per ommatidia.

Light responses in mutant photoreceptors have essentially wild-type properties.

Border cell migration is normal in sl1/sl2 mutants.

Homozygotes show a modest reduction in wing length and a mildly rough eye. In addition, homozygotes show ectopic wing veins, most frequently adjacent to L2 but sometimes connected or adjacent to the posterior crossvein or in the posterior cell. Ommatidial array is disrupted, many ommatidia are abnormally shaped. Eyes show interommatidial bristle defects. Some are missing, some are duplicated and some appear at additional vertices. 51% of ommatidia contain extra inner photoreceptors. A small fraction of ommatidia have one or more extra (2%) or missing (10%) outer photoreceptors. The majority of supernumerary photoreceptors show an R7 identity. Homozygotes contain as many as three more cone cells than wild type, and an extra primary pigment cell is sometimes present.

Similar to sl1 but possibly more extreme. RK2.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

sl2 has size defective | adult stage phenotype, enhanceable by Egfr[+]/Egfrf2

sl2 has size defective | adult stage phenotype, enhanceable by spi1/spi[+]

sl2 has size defective | adult stage phenotype, enhanceable by vn[+]/vnC221

sl2 has size defective | adult stage phenotype, enhanceable by aos[+]/aosΔ7

sl2 has visible | adult stage phenotype, enhanceable by aos[+]/aosΔ7

sl2 has size defective | adult stage phenotype, enhanceable by InR[+]/InRE19

sl2 has size defective | adult stage phenotype, enhanceable by Pi3K92E5W3/Pi3K92E[+]

sl2 has size defective | adult stage phenotype, enhanceable by ItprB4/Itp-r83A[+]

sl2 has increased cell number | adult stage phenotype, enhanceable by ItprB4/Itp-r83A[+]

sl2 has size defective | adult stage phenotype, enhanceable by dos[+]/dosR31

sl2 has size defective | adult stage phenotype, enhanceable by Rack1[+]/Rack1EE

sl2 has size defective | adult stage phenotype, enhanceable by rhove-1/rho[+]

sl2 has size defective | adult stage phenotype, enhanceable by S[+]/S2

NOT Enhanced by
Statement
Reference

sl2 has size defective | adult stage phenotype, non-enhanceable by chico1/chico[+]

sl2 has increased cell number | adult stage phenotype, non-enhanceable by Rack1[+]/Rack1EE

Suppressed by
Statement
Reference

sl2 has size defective | adult stage phenotype, suppressible by Akt1[+]/Akt11

NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

sl2 is a suppressor of visible phenotype of Pp2B-14Dact.GMR

Phenotype Manifest In
Enhanced by
Statement
Reference

sl2 has wing blade phenotype, enhanceable by Egfr[+]/Egfrf2

sl2 has wing blade phenotype, enhanceable by vn[+]/vnC221

sl2 has wing blade phenotype, enhanceable by aos[+]/aosΔ7

sl2 has wing vein | ectopic phenotype, enhanceable by aos[+]/aosΔ7

sl2 has eye phenotype, enhanceable by aos[+]/aosΔ7

sl2 has wing blade phenotype, enhanceable by InR[+]/InRE19

sl2 has wing vein | ectopic phenotype, enhanceable by InR[+]/InRE19

sl2 has wing blade phenotype, enhanceable by Pi3K92E5W3/Pi3K92E[+]

sl2 has wing blade phenotype, enhanceable by dos[+]/dosR31

sl2 has wing blade phenotype, enhanceable by ItprB4/Itp-r83A[+]

sl2 has wing vein | ectopic phenotype, enhanceable by ItprB4/Itp-r83A[+]

sl2 has photoreceptor cell R7 | adult stage phenotype, enhanceable by ItprB4/Itp-r83A[+]

sl2 has wing blade phenotype, enhanceable by Pkc53E[+]/Pkc53EEY14093

sl2 has wing vein | ectopic phenotype, enhanceable by Pkc53E[+]/Pkc53EEY14093

sl2 has wing blade phenotype, enhanceable by Rack1[+]/Rack1EE

sl2 has wing vein | ectopic phenotype, enhanceable by Rack1[+]/Rack1EE

sl2 has wing blade phenotype, enhanceable by rhove-1/rho[+]

sl2 has wing vein | ectopic phenotype, enhanceable by rhove-1/rho[+]

sl2 has wing blade phenotype, enhanceable by drk[+]/drke0A/drke0A

sl2 has wing blade phenotype, enhanceable by S[+]/S2

sl2 has wing vein | ectopic phenotype, enhanceable by S[+]/S2

sl2 has wing blade phenotype, enhanceable by Sos[+]/Sos34Ea-6

sl2 has wing blade phenotype, enhanceable by spi1/spi[+]

NOT Enhanced by
Statement
Reference

sl2 has wing vein | ectopic phenotype, non-enhanceable by spi1/spi[+]

sl2 has wing blade phenotype, non-enhanceable by chico1/chico[+]

sl2 has wing vein | ectopic phenotype, non-enhanceable by chico1/chico[+]

sl2 has wing vein | ectopic phenotype, non-enhanceable by Akt1[+]/Akt11

sl2 has photoreceptor cell R7 | adult stage phenotype, non-enhanceable by Rack1[+]/Rack1EE

sl2 has photoreceptor cell R7 | supernumerary phenotype, non-enhanceable by dos[+]/dosP

Suppressed by
Statement
Reference

sl2 has wing vein | ectopic phenotype, suppressible | partially by dos[+]/dosR31

sl2 has wing vein | ectopic phenotype, suppressible | partially by drk[+]/drke0A/drke0A

sl2 has wing vein | ectopic phenotype, suppressible | partially by Egfr[+]/Egfrf2

sl2 has wing vein | ectopic phenotype, suppressible | partially by Sos[+]/Sos34Ea-6

sl2 has wing vein | ectopic phenotype, suppressible | partially by vn[+]/vnC221

sl2 has wing vein | ectopic phenotype, suppressible | partially by Pi3K92E5W3/Pi3K92E[+]

sl2 has wing blade phenotype, suppressible by Akt1[+]/Akt11

sl2 has wing vein | ectopic phenotype, suppressible | partially by Ras85De2F/Ras85D[+]

sl2 has photoreceptor cell R7 | ectopic phenotype, suppressible by Egfr[+]/Egfrf2

sl2 has photoreceptor cell R7 | ectopic phenotype, suppressible by Egfrf3/Egfr[+]

NOT suppressed by
Statement
Reference

sl2 has photoreceptor cell R7 | supernumerary phenotype, non-suppressible by dos[+]/dosP

NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

sl2/sl2 is a suppressor of ommatidium phenotype of ru1

sl2 is a suppressor of eye phenotype of Pp2B-14Dact.GMR

sl2 is a suppressor of eye phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

NOT Suppressor of
Statement
Reference

sl2 is a non-suppressor of photoreceptor cell R7 phenotype of sina2

Other
Additional Comments
Genetic Interactions
Statement
Reference

One copy of Egfrf2 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of dosR31 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of drke0A enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of Sos34Ea-6 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of spi1 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of vnC221 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of aosΔ7 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of InRE19 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of chico1 does not enhance the reduction in wing blade area seen in homozygous sl2 males.

One copy of Pi3K92E5W3 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of Akt11 suppresses the reduction in wing blade area seen in homozygous sl2 males, resulting in wings that are larger than wild type.

One copy of Itp-r83AB4 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of Pkc53EEY14093 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of Rack1EE enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of rhove-1 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of S2 enhances the reduction in wing blade area seen in homozygous sl2 males.

One copy of aosΔ7 significantly enhances the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of spi1 does not enhance the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of Egfrf2 partially suppresses the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of dosR31 partially suppresses the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of drke0A partially suppresses the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of Sos34Ea-6 partially suppresses the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of Ras85De2F partially suppresses the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of vnC221 partially suppresses the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of InRE19 significantly enhances the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of Pi3K92E5W3 partially suppresses the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of chico1 does not enhance the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of Akt11 does not enhance the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of Itp-r83AB4 significantly enhances the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of Rack1EE significantly enhances the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of Pkc53EEY14093 significantly enhances the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of rhove-1 significantly enhances the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of S2 significantly enhances the ectopic wing vein phenotype seen in sl2 homozygotes.

One copy of aosΔ7 dramatically enhances the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors. The eyes also appear rougher than in sl2 mutants alone.

One copy of InRE19 enhances the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors.

One copy of InR93Dj-4 enhances the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also increased.

One copy of chico1 partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors.

One copy of Pi3K92E5W3 partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors.

One copy of Akt11 partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors.

One copy of Itp-r83AB4 enhances the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also increased.

One copy of Pkc53EEY14093 enhances the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also increased.

One copy of Rack1EE does not enhance the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors.

One copy of rhove-1 partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also reduced.

One copy of spi1 partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also reduced.

sl2 does not enhance the dominant R7 photoreceptor loss seen in S2 heterozygotes.

One copy of rl1 partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors.

One copy of Sos34Ea-6 partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors.

One copy of vnC221 partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors.

One copy of dosR31 partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors.

One copy of Egfrf2 partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors.

One copy of drke0A partially suppresses the percentage of sl2 mutant ommatidia that contain extra R7 photoreceptors.

The viability of Itp-r83Awc703/Itp-r83Awc361 animals is unaffected by sl2/sl2.

The defects in ommatidial rotation seen in ru1 homozygotes are almost completely suppressed by sl2/sl2.

The number of R7 cells per ommatidia in sl2 animals is not altered if they are also heterozygous for dosP.

Eye supernumerary R7 cell phenotype of sl1 and sl2 is almost completely suppressed by reducing the dosage of Egfr, as in heterozygotes for Egfrf2 and Egfrf3. Double mutants of sl1 or sl2 with either sev1 or sev14 show a mutant phenotype intermediate to that of either single mutant: 35-49% of ommatidia have one R7 cell, 6-12% contain two R7 cells and the rest have no R7 cells. Double mutants with sl1 or sl2 and rl1 show phenotypes very close to that of rl1 alone. Double mutants of sl2 with sina2 show no increase in proportion of R7 cells over that seen for sina2 alone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

sl2 is partially rescued by slN-SH2

Comments

Expression of sl+t10 rescues the wing size defects, ectopic veins and extra R7 photoreceptor phenotypes seen in sl2 mutants.

Expression of slN-SH2 rescues the wing size defects seen in sl2 mutants The ectopic vein and extra R7 photoreceptor phenotypes are only partially rescued.

Expression of slC-SH2 rescues the wing size defects, ectopic veins and extra R7 photoreceptor phenotypes seen in sl2 mutants.

Complementation data based on rough eye and wing phenotypes.

Images (0)
Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer

Dobzhansky, 3rd Feb. 1931.

Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (15)