FlyBase Allele Report: Dmel\sl[2]

General Information

Symbol

Dmel\sl²

Species

D. melanogaster

Name

FlyBase ID

FBal0015678

Feature type

allele

Associated gene

Dmel\sl

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(Thackeray et al., 1998)

Mutagen

X ray

Progenitor genotype

Cytology

Description

13bp deletion, beginning 3' of nucleotide 2027 of FBrf0073038, at the beginning of the first SH2 domain, which creates a stop codon beginning at nucleotide 2090.

(Thackeray et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:16,352,695..16,352,707 [+]

Comment:

13bp deletion beginning 3' of nucleotide 2027 of FBrf0073038

(Thackeray et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cone cell

(Thackeray et al., 1998)

embryonic/larval crystal cell | increased number | larval stage

(Destalminil-Letourneau et al., 2021)

eye

(Murillo-Maldonado et al., 2011, Thackeray et al., 1998)

eye photoreceptor cell

(Thackeray et al., 1998)

interommatidial bristle

(Thackeray et al., 1998)

interommatidial bristle | ectopic

(Thackeray et al., 1998)

ommatidium

(Schlesinger et al., 2004, Thackeray et al., 1998)

photoreceptor cell R7

(Schlesinger et al., 2004)

photoreceptor cell R7 | adult stage

(Murillo-Maldonado et al., 2011)

photoreceptor cell R7 | ectopic

(Thackeray et al., 1998)

photoreceptor cell R7 | increased number

(Abbeyquaye et al., 2003)

primary pigment cell

(Thackeray et al., 1998)

wing

(Thackeray et al., 1998)

wing (with sl^{CR01192-TG4.0})

(Ma et al., 2025)

wing blade

(Murillo-Maldonado et al., 2011)

wing vein | ectopic

(Murillo-Maldonado et al., 2011, Thackeray et al., 1998)

wing vein | ectopic (with sl^{CR01192-TG4.0})

(Ma et al., 2025)

Detailed Description

Statement

Reference

Wing blade area is reduced by 20% in homozygous sl² mutant males compared to wild type. This reduction can be explained by an increase in cell density as wing cells are 21% smaller than in controls but cell number is not significantly different.

sl² mutant flies sometimes show small ectopic wing veins.

Approximately 23% of sl² mutant ommatidia contain an increased number of R7 photoreceptors compared to wild type.

(Murillo-Maldonado et al., 2011)

Germaria mutant for sl² do not exhibit ectopic spectrosome containing cells.

(Liu et al., 2010)

In the eyes of sl² homozygous flies, ~22% of ommatidia are misrotated and almost half have between one and three extra R7 cells.

(Schlesinger et al., 2004)

Mutants have 1.253 +/- 0.038 R7 cells per ommatidia.

(Abbeyquaye et al., 2003)

Light responses in mutant photoreceptors have essentially wild-type properties.

(Hardie et al., 2003)

Border cell migration is normal in sl¹/sl² mutants.

(Duchek and Rorth, 2001)

Homozygotes show a modest reduction in wing length and a mildly rough eye. In addition, homozygotes show ectopic wing veins, most frequently adjacent to L2 but sometimes connected or adjacent to the posterior crossvein or in the posterior cell. Ommatidial array is disrupted, many ommatidia are abnormally shaped. Eyes show interommatidial bristle defects. Some are missing, some are duplicated and some appear at additional vertices. 51% of ommatidia contain extra inner photoreceptors. A small fraction of ommatidia have one or more extra (2%) or missing (10%) outer photoreceptors. The majority of supernumerary photoreceptors show an R7 identity. Homozygotes contain as many as three more cone cells than wild type, and an extra primary pigment cell is sometimes present.

(Thackeray et al., 1998)

Similar to sl¹ but possibly more extreme. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

sl² has abnormal size | adult stage phenotype, enhanceable by Egfr[+]/Egfr^f2

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by spi¹/spi[+]

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by vn[+]/vn^C221

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by aos[+]/aos^Δ7

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, enhanceable by aos[+]/aos^Δ7

(Murillo-Maldonado et al., 2011)

sl² has visible | adult stage phenotype, enhanceable by aos[+]/aos^Δ7

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by InR[+]/InR^E19

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, enhanceable by InR[+]/InR^E19

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by Pi3K92E^5W3/Pi3K92E[+]

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by Itpr^B4/Itp-r83A[+]

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, enhanceable by Itpr^B4/Itp-r83A[+]

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by dos[+]/dos^R31

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by Pkc53E[+]/Pkc53E^EY14093

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, enhanceable by Pkc53E[+]/Pkc53E^EY14093

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by Rack1[+]/Rack1^EE

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by rho^ve-1/rho[+]

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by S[+]/S²

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, enhanceable by InR[+]/InR^93Dj-4

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by drk[+]/drk^e0A

(Murillo-Maldonado et al., 2011)

sl² has abnormal size | adult stage phenotype, enhanceable by Sos[+]/Sos^34Ea-6

(Murillo-Maldonado et al., 2011)

NOT Enhanced by

Statement

Reference

sl² has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^dome-PG125/btl^λ.UAS

(Destalminil-Letourneau et al., 2021)

sl² has abnormal size | adult stage phenotype, non-enhanceable by chico¹/chico[+]

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, non-enhanceable by Rack1[+]/Rack1^EE

(Murillo-Maldonado et al., 2011)

Suppressed by

Statement

Reference

sl² has abnormal size | adult stage phenotype, suppressible by Akt1[+]/Akt¹

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, suppressible by chico¹/chico[+]

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, suppressible by Pi3K92E^5W3/Pi3K92E[+]

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, suppressible by Akt1[+]/Akt¹

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, suppressible by rho^ve-1/rho[+]

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, suppressible by spi¹/spi[+]

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, suppressible by rl[+]/rl¹

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, suppressible by Sos[+]/Sos^34Ea-6

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, suppressible by vn[+]/vn^C221

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, suppressible by dos[+]/dos^R31

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, suppressible by Egfr[+]/Egfr^f2

(Murillo-Maldonado et al., 2011)

sl² has increased cell number | adult stage phenotype, suppressible by drk[+]/drk^e0A

(Murillo-Maldonado et al., 2011)

NOT suppressed by

Statement

Reference

sl² has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^dome-PG125/btl^λ.UAS

(Destalminil-Letourneau et al., 2021)

NOT Enhancer of

Statement

Reference

sl² is a non-enhancer of decreased cell number | adult stage | dominant phenotype of S²

(Murillo-Maldonado et al., 2011)

Suppressor of

Statement

Reference

sl²/sl² is a suppressor of abnormal planar polarity | recessive phenotype of ru¹

(Schlesinger et al., 2004)

sl² is a suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

sl² is a suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

sl² has wing blade phenotype, enhanceable by Egfr[+]/Egfr^f2

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by vn[+]/vn^C221

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by aos[+]/aos^Δ7

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, enhanceable by aos[+]/aos^Δ7

(Murillo-Maldonado et al., 2011)

sl² has eye phenotype, enhanceable by aos[+]/aos^Δ7

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, enhanceable by aos[+]/aos^Δ7

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by InR[+]/InR^E19

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, enhanceable by InR[+]/InR^E19

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, enhanceable by InR[+]/InR^E19

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by Pi3K92E^5W3/Pi3K92E[+]

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by dos[+]/dos^R31

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by Itpr^B4/Itp-r83A[+]

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, enhanceable by Itpr^B4/Itp-r83A[+]

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, enhanceable by Itpr^B4/Itp-r83A[+]

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by Pkc53E[+]/Pkc53E^EY14093

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, enhanceable by Pkc53E[+]/Pkc53E^EY14093

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, enhanceable by Pkc53E[+]/Pkc53E^EY14093

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by Rack1[+]/Rack1^EE

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, enhanceable by Rack1[+]/Rack1^EE

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by rho^ve-1/rho[+]

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, enhanceable by rho^ve-1/rho[+]

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by drk[+]/drk^e0A

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by S[+]/S²

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, enhanceable by S[+]/S²

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, enhanceable by InR[+]/InR^93Dj-4

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by Sos[+]/Sos^34Ea-6

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, enhanceable by spi¹/spi[+]

(Murillo-Maldonado et al., 2011)

NOT Enhanced by

Statement

Reference

sl² has embryonic/larval crystal cell | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^dome-PG125/btl^λ.UAS

(Destalminil-Letourneau et al., 2021)

sl² has wing vein | ectopic phenotype, non-enhanceable by spi¹/spi[+]

(Murillo-Maldonado et al., 2011)

sl² has wing blade phenotype, non-enhanceable by chico¹/chico[+]

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, non-enhanceable by chico¹/chico[+]

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, non-enhanceable by Akt1[+]/Akt¹

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, non-enhanceable by Rack1[+]/Rack1^EE

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | increased number phenotype, non-enhanceable by dos[+]/dos^P

(Abbeyquaye et al., 2003)

Suppressed by

Statement

Reference

sl² has wing blade phenotype, suppressible by Akt1[+]/Akt¹

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, suppressible by Egfr[+]/Egfr^f2

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, suppressible by dos[+]/dos^R31

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, suppressible by drk[+]/drk^e0A

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, suppressible by Sos[+]/Sos^34Ea-6

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, suppressible by Ras85D^e2F/Ras85D[+]

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, suppressible by vn[+]/vn^C221

(Murillo-Maldonado et al., 2011)

sl² has wing vein | ectopic phenotype, suppressible by Pi3K92E^5W3/Pi3K92E[+]

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, suppressible by chico¹/chico[+]

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, suppressible by Pi3K92E^5W3/Pi3K92E[+]

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, suppressible by Akt1[+]/Akt¹

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, suppressible by rho^ve-1/rho[+]

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, suppressible by spi¹/spi[+]

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, suppressible by rl[+]/rl¹

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, suppressible by Sos[+]/Sos^34Ea-6

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, suppressible by vn[+]/vn^C221

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, suppressible by dos[+]/dos^R31

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, suppressible by Egfr[+]/Egfr^f2

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | adult stage phenotype, suppressible by drk[+]/drk^e0A

(Murillo-Maldonado et al., 2011)

sl² has photoreceptor cell R7 | ectopic phenotype, suppressible by Egfr[+]/Egfr^f2

(Thackeray et al., 1998)

sl² has photoreceptor cell R7 | ectopic phenotype, suppressible by Egfr^f3/Egfr[+]

(Thackeray et al., 1998)

NOT suppressed by

Statement

Reference

sl² has embryonic/larval crystal cell | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^dome-PG125/btl^λ.UAS

(Destalminil-Letourneau et al., 2021)

sl² has photoreceptor cell R7 | increased number phenotype, non-suppressible by dos[+]/dos^P

(Abbeyquaye et al., 2003)

NOT Enhancer of

Statement

Reference

sl² is a non-enhancer of photoreceptor cell R7 | adult stage phenotype of S²

(Murillo-Maldonado et al., 2011)

Suppressor of

Statement

Reference

sl²/sl² is a suppressor of ommatidium phenotype of ru¹

(Schlesinger et al., 2004)

sl² is a suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

sl² is a suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

NOT Suppressor of

Statement

Reference

sl² is a non-suppressor of photoreceptor cell R7 phenotype of sina²

(Thackeray et al., 1998)

Other

Statement

Reference

sev¹, sl² has photoreceptor cell R7 phenotype

(Thackeray et al., 1998)

sev¹⁴, sl² has photoreceptor cell R7 phenotype

(Thackeray et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Egfr^f2 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of dos^R31 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of drk^e0A enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of Sos^34Ea-6 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of spi¹ enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of vn^C221 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of aos^Δ7 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of InR^E19 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of chico¹ does not enhance the reduction in wing blade area seen in homozygous sl² males.

One copy of Pi3K92E^5W3 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of Akt1¹ suppresses the reduction in wing blade area seen in homozygous sl² males, resulting in wings that are larger than wild type.

One copy of Itp-r83A^B4 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of Pkc53E^EY14093 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of Rack1^EE enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of rho^ve-1 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of S² enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of aos^Δ7 significantly enhances the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of spi¹ does not enhance the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Egfr^f2 partially suppresses the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of dos^R31 partially suppresses the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of drk^e0A partially suppresses the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Sos^34Ea-6 partially suppresses the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Ras85D^e2F partially suppresses the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of vn^C221 partially suppresses the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of InR^E19 significantly enhances the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Pi3K92E^5W3 partially suppresses the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of chico¹ does not enhance the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Akt1¹ does not enhance the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Itp-r83A^B4 significantly enhances the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Rack1^EE significantly enhances the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Pkc53E^EY14093 significantly enhances the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of rho^ve-1 significantly enhances the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of S² significantly enhances the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of aos^Δ7 dramatically enhances the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors. The eyes also appear rougher than in sl² mutants alone.

One copy of InR^E19 enhances the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

One copy of InR^93Dj-4 enhances the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also increased.

One copy of chico¹ partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

One copy of Pi3K92E^5W3 partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

One copy of Akt1¹ partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

One copy of Itp-r83A^B4 enhances the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also increased.

One copy of Pkc53E^EY14093 enhances the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also increased.

One copy of Rack1^EE does not enhance the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

One copy of rho^ve-1 partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also reduced.

One copy of spi¹ partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors. The number of R7 cells per ommatidium is also reduced.

sl² does not enhance the dominant R7 photoreceptor loss seen in S² heterozygotes.

One copy of rl¹ partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

One copy of Sos^34Ea-6 partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

One copy of vn^C221 partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

One copy of dos^R31 partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

One copy of Egfr^f2 partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

One copy of drk^e0A partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

(Murillo-Maldonado et al., 2011)

The viability of Itp-r83A^wc703/Itp-r83A^wc361 animals is unaffected by sl²/sl².

(Banerjee et al., 2006)

The defects in ommatidial rotation seen in ru¹ homozygotes are almost completely suppressed by sl²/sl².

(Schlesinger et al., 2004)

The number of R7 cells per ommatidia in sl² animals is not altered if they are also heterozygous for dos^P.

(Abbeyquaye et al., 2003)

Eye supernumerary R7 cell phenotype of sl¹ and sl² is almost completely suppressed by reducing the dosage of Egfr, as in heterozygotes for Egfr^f2 and Egfr^f3. Double mutants of sl¹ or sl² with either sev¹ or sev¹⁴ show a mutant phenotype intermediate to that of either single mutant: 35-49% of ommatidia have one R7 cell, 6-12% contain two R7 cells and the rest have no R7 cells. Double mutants with sl¹ or sl² and rl¹ show phenotypes very close to that of rl¹ alone. Double mutants of sl² with sina² show no increase in proportion of R7 cells over that seen for sina² alone.

(Thackeray et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sl³

(Thackeray et al., 1998)

sl¹

(Thackeray et al., 1998)

Rescued by

sl² is rescued by sl^+t10

(Murillo-Maldonado et al., 2011)

sl² is rescued by sl^C-SH2

(Murillo-Maldonado et al., 2011)

Partially rescued by

sl² is partially rescued by sl^N-SH2

(Murillo-Maldonado et al., 2011)

Comments

Expression of sl^+t10 rescues the wing size defects, ectopic veins and extra R7 photoreceptor phenotypes seen in sl² mutants.

Expression of sl^N-SH2 rescues the wing size defects seen in sl² mutants The ectopic vein and extra R7 photoreceptor phenotypes are only partially rescued.

Expression of sl^C-SH2 rescues the wing size defects, ectopic veins and extra R7 photoreceptor phenotypes seen in sl² mutants.

(Murillo-Maldonado et al., 2011)

Complementation data based on rough eye and wing phenotypes.

(Thackeray et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

724

In(1)bb^Df, y¹ sl²/FM4

5735

rud¹ v^54k tc¹ sl² smd¹/FM7c, sn⁺

Kyoto

106046

In(1)bb^Df, y¹ sl²/FM4

108394

rud¹ v^54k tc¹ sl² smd¹/FM7a

Notes on Origin

Discoverer

Dobzhansky, 3rd Feb. 1931.

Comments

Null allele.

(Thackeray et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

plc-γ²

(Liu et al., 2010)

sl²

(Ma et al., 2025, Destalminil-Letourneau et al., 2021, Murillo-Maldonado et al., 2011, Popodi et al., 2010-, Schlesinger et al., 2004, Settle et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (17)

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