FlyBase Allele Report: Dmel\Pi3K92E[5W3]

General Information

Symbol

Dmel\Pi3K92E^5W3

Species

D. melanogaster

Name

FlyBase ID

FBal0152313

Feature type

allele

Associated gene

Dmel\Pi3K92E

Associated Insertion(s)

Carried in Construct

Also Known As

Dp110^5W3

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of type 2 diabetes mellitus

CEA

(Murillo-Maldonado et al., 2011)

CEA with Pi3K92E^2H1

(Murillo-Maldonado et al., 2011)

CEA with Pi3K92E^A

(Murillo-Maldonado et al., 2011)

model of glucose metabolism disease

CEA with Pi3K92E^A

(Álvarez-Rendón and Riesgo-Escovar, 2020)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | adult stage (with Pi3K92E^2H1)

(Murillo-Maldonado et al., 2011)

abnormal neurophysiology | adult stage (with Pi3K92E^A)

(Murillo-Maldonado et al., 2011)

abnormal neurophysiology | adult stage | recessive

(Murillo-Maldonado et al., 2011)

decreased body size | adult stage (with Pi3K92E^2H1)

(Murillo-Maldonado et al., 2011)

decreased body size | adult stage (with Pi3K92E^A)

(Murillo-Maldonado et al., 2011)

decreased body size | adult stage | recessive

(Murillo-Maldonado et al., 2011)

viable

(Murillo-Maldonado et al., 2011)

viable (with Pi3K92E^2H1)

(Murillo-Maldonado et al., 2011)

viable (with Pi3K92E^A)

(Murillo-Maldonado et al., 2011)

visible | adult stage (with Pi3K92E^2H1)

(Murillo-Maldonado et al., 2011)

visible | adult stage | recessive

(Murillo-Maldonado et al., 2011)

visible | somatic clone

(Junger et al., 2003)

Phenotype Manifest In

adult head capsule | somatic clone

(Junger et al., 2003)

wing (with Pi3K92E^2H1)

(Murillo-Maldonado et al., 2011)

Detailed Description

Statement

Reference

Homozygous Pi3K92E^5W3 mutant adult flies have a reduced body weight compared to heterozygous controls.

Lipid and carbohydrate content are not increased in homozygous Pi3K92E^5W3 mutant flies compared to controls.

Homozygous Pi3K92E^5W3 mutant flies exhibit defective electroretinogram (ERG) readings.

Cholinesterase activity is significantly reduced in homozygous Pi3K92E^5W3 mutant flies compared to controls.

Pi3K92E^2H1/Pi3K92E^5W3 mutant adult flies have a reduced body weight compared to heterozygous controls. Wing area is also reduced compared to controls.

Lipid and carbohydrate content are increased in Pi3K92E^2H1/Pi3K92E^5W3 mutant flies compared to controls.

Pi3K92E^2H1/Pi3K92E^5W3 mutant flies exhibit defective electroretinogram (ERG) readings.

Cholinesterase activity is not significantly reduced in Pi3K92E^2H1/Pi3K92E^5W3 mutant flies compared to controls.

Pi3K92E^A/Pi3K92E^5W3 mutant adult flies have a reduced body weight compared to heterozygous controls.

Lipid and carbohydrate content are increased in Pi3K92E^A/Pi3K92E^5W3 mutant flies compared to controls.

Pi3K92E^A/Pi3K92E^5W3 mutant flies exhibit defective electroretinogram (ERG) readings.

Cholinesterase activity is not significantly reduced in Pi3K92E^A/Pi3K92E^5W3 mutant flies compared to controls.

(Murillo-Maldonado et al., 2011)

Head capsule reduced - pinhead phenotype.

(Junger et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Pi3K92E^5W3 has visible | somatic clone phenotype, suppressible | partially by foxo²⁵

(Junger et al., 2003)

Enhancer of

Statement

Reference

Pi3K92E^5W3/Pi3K92E[+] is an enhancer of abnormal size | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Suppressor of

Statement

Reference

Pi3K92E^5W3/Pi3K92E[+] is a suppressor of increased cell number | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Phenotype Manifest In

Suppressed by

Statement

Reference

Pi3K92E^5W3 has adult head capsule | somatic clone phenotype, suppressible | partially by foxo²⁵

(Junger et al., 2003)

Enhancer of

Statement

Reference

Pi3K92E^5W3/Pi3K92E[+] is an enhancer of wing blade phenotype of sl²

(Murillo-Maldonado et al., 2011)

Suppressor of

Statement

Reference

Pi3K92E^5W3/Pi3K92E[+] is a suppressor of wing vein | ectopic phenotype of sl²

(Murillo-Maldonado et al., 2011)

Pi3K92E^5W3/Pi3K92E[+] is a suppressor of photoreceptor cell R7 | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Pi3K92E^5W3 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of Pi3K92E^5W3 partially suppresses the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of Pi3K92E^5W3 partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

(Murillo-Maldonado et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dp110^5W3

(Murillo-Maldonado et al., 2011, Murillo-Maldonado et al., 2011, Junger et al., 2003)

Dp110^5w3

(Álvarez-Rendón and Riesgo-Escovar, 2020)

Pi3K92E^5W3

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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