FlyBase Allele Report: Dmel\Pi3K92E[2H1]

General Information

Symbol

Dmel\Pi3K92E^2H1

Species

D. melanogaster

Name

FlyBase ID

FBal0123129

Feature type

allele

Associated gene

Dmel\Pi3K92E

Associated Insertion(s)

Carried in Construct

Also Known As

Dp110^2H1

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of type 2 diabetes mellitus

CEA

(Murillo-Maldonado et al., 2011)

CEA with Pi3K92E^A

(Murillo-Maldonado et al., 2011)

CEA with Pi3K92E^5W3

(Murillo-Maldonado et al., 2011)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing

(Murillo-Maldonado et al., 2011)

wing (with Pi3K92E^5W3)

(Murillo-Maldonado et al., 2011)

Detailed Description

Statement

Reference

Homozygous Pi3K92E^2H1 mutant adult flies have a reduced body weight compared to heterozygous controls. Wing area is also reduced compared to controls.

Lipid content is increased in homozygous Pi3K92E^2H1 mutant flies compared to controls. Carbohydrate content is similar to controls.

Homozygous Pi3K92E^2H1 mutant flies exhibit defective electroretinogram (ERG) readings.

Pi3K92E^2H1/Pi3K92E^A mutant adult flies have a reduced body weight compared to heterozygous controls.

Lipid and carbohydrate content are increased in Pi3K92E^2H1/Pi3K92E^A mutant flies compared to controls.

Pi3K92E^2H1/Pi3K92E^A mutant flies exhibit normal electroretinogram (ERG) readings.

Cholinesterase activity is not significantly reduced in Pi3K92E^2H1/Pi3K92E^A mutant flies compared to controls.

Pi3K92E^2H1/Pi3K92E^5W3 mutant adult flies have a reduced body weight compared to heterozygous controls. Wing area is also reduced compared to controls.

Lipid and carbohydrate content are increased in Pi3K92E^2H1/Pi3K92E^5W3 mutant flies compared to controls.

Pi3K92E^2H1/Pi3K92E^5W3 mutant flies exhibit defective electroretinogram (ERG) readings.

Cholinesterase activity is not significantly reduced in Pi3K92E^2H1/Pi3K92E^5W3 mutant flies compared to controls.

(Murillo-Maldonado et al., 2011)

The Pi3K92E^A/Pi3K92E^2H1 combination results in proportionally smaller than normal flies.

(Halfar et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Pi3K92E^2H1/Pi3K92E^A is a non-suppressor of visible phenotype of Ras85D^{G12V.Y40C.UAS}, Scer\GAL4^GMR.PF

(Halfar et al., 2001)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Pi3K92E^2H1/Pi3K92E^A is a non-suppressor of ommatidium phenotype of Ras85D^{G12V.Y40C.UAS}, Scer\GAL4^GMR.PF

(Halfar et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Ras85D^{G12V.Y40C.Scer\UAS} under the control of Scer\GAL4^GMR.PF is not suppressed by Pi3K92E^A/Pi3K92E^2H1.

(Halfar et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dp110^2H1

(Murillo-Maldonado et al., 2011, Halfar et al., 2001)

PI3K92E^2H1

(Nowak et al., 2013)

Pi3K92E^2H1

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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