FlyBase Allele Report: Dmel\vn[C221]

General Information

Symbol

Dmel\vn^C221

Species

D. melanogaster

Name

FlyBase ID

FBal0081947

Feature type

allele

Associated gene

Dmel\vn

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Price et al., 1997)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with vn¹)

(Rendina et al., 2010)

Phenotype Manifest In

anterior crossvein

(Marenda et al., 2004, Price et al., 1997)

wing

(Price et al., 1997)

wing vein L4

(Price et al., 1997)

wing vein L4 (with vn¹)

(Rendina et al., 2010)

Detailed Description

Statement

Reference

vn¹/vn^C221 animals lack the L4 wing vein.

(Rendina et al., 2010)

Heterozygotes show an incomplete or deleted anterior crossvein in 5% of wings.

(Marenda et al., 2004)

vn^C221/vn¹ transheterozygotes are viable and display deletions of the anterior crossvein and a portion of wing vein L4 proximal to the posterior crossvein. vn^C221/vn^ddd-13 transheterozygotes are semi-viable at 25^oC, escapers survive for 3 days and are of normal appearance except for held-out wings and the absence of anterior cross vein.

(Price et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

vn^C221/vn¹ has visible phenotype, suppressible by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

Enhancer of

Statement

Reference

vn[+]/vn^C221 is an enhancer of abnormal size | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

vn^C221 is an enhancer of visible phenotype of Egfr^t1

(Price et al., 1997)

Suppressor of

Statement

Reference

vn[+]/vn^C221 is a suppressor of increased cell number | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

vn[+]/vn^C221 is a suppressor of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

vn^C221 is a suppressor of visible phenotype of N^55e11

(Price et al., 1997)

vn^C221 is a suppressor of visible phenotype of Su(H)¹⁶

(Price et al., 1997)

Other

Statement

Reference

brm[+]/brm², vn^C221 has visible phenotype

(Armstrong et al., 2005)

brm², vn[+]/vn^C221 has visible | dominant phenotype

(Armstrong et al., 2005)

E(Egfr)B56^B56, vn^C221 has visible phenotype

(Price et al., 1997)

Df(2R)Egfr18, vn^C221 has visible phenotype

(Price et al., 1997)

E(Egfr)C12^C12, vn^C221 has visible phenotype

(Price et al., 1997)

H^C21, vn^C221 has visible phenotype

(Price et al., 1997)

gro^C105, vn^C221 has visible phenotype

(Price et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

vn^C221 has humeral bristle phenotype, enhanceable by brm[+]/brm²

(Armstrong et al., 2005)

Suppressed by

Statement

Reference

vn^C221/vn¹ has wing vein L4 phenotype, suppressible by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

Enhancer of

Statement

Reference

vn[+]/vn^C221 is an enhancer of wing blade phenotype of sl²

(Murillo-Maldonado et al., 2011)

vn^C221 is an enhancer of wing vein L4 phenotype of Egfr^t1

(Price et al., 1997)

Suppressor of

Statement

Reference

vn[+]/vn^C221 is a suppressor of photoreceptor cell R7 | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

vn[+]/vn^C221 is a suppressor of wing vein | ectopic phenotype of sl²

(Murillo-Maldonado et al., 2011)

vn^C221/Scer\GAL4^Tub.PU is a suppressor | partially of wing vein phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

vn[+]/vn^C221 is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

vn^C221 is a suppressor of wing phenotype of N^55e11

(Price et al., 1997)

vn^C221 is a suppressor of wing phenotype of Su(H)¹⁶

(Price et al., 1997)

Other

Statement

Reference

brm², vn^C221 has wing phenotype

(Armstrong et al., 2005)

brm², vn[+]/vn^C221 has wing phenotype

(Armstrong et al., 2005)

E(Egfr)B56^B56, vn^C221 has wing vein L2 phenotype

(Price et al., 1997)

E(Egfr)B56^B56, vn^C221 has wing vein L5 phenotype

(Price et al., 1997)

gro^C105, vn^C221 has anterior crossvein phenotype

(Price et al., 1997)

gro^C105, vn^C221 has wing vein L4 phenotype

(Price et al., 1997)

Df(2R)Egfr18, vn^C221 has wing vein L4 phenotype

(Price et al., 1997)

E(Egfr)C12^C12, vn^C221 has anterior crossvein phenotype

(Price et al., 1997)

E(Egfr)C12^C12, vn^C221 has wing vein L4 phenotype

(Price et al., 1997)

E(Egfr)B56^B56, vn^C221 has wing vein L4 phenotype

(Price et al., 1997)

H^C21, vn^C221 has wing vein L5 phenotype

(Price et al., 1997)

H^C21, vn^C221 has wing vein L4 phenotype

(Price et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of vn^C221 enhances the reduction in wing blade area seen in homozygous sl² males.

One copy of vn^C221 partially suppresses the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of vn^C221 partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

(Murillo-Maldonado et al., 2011)

The loss of wing vein L4 which is seen in vn¹/vn^C221 animals is rescued by Bap170^hfl1/+ in 90% of cases.

(Rendina et al., 2010)

The presence of a vn^C221 background causes minor suppression of ectopic wing vein formation found in csw^{Y279C.Scer\UAS} (Scer\GAL4^tub) mutants.

(Oishi et al., 2009)

vn^C221/Snr1^E1 animals show an incomplete or deleted anterior crossvein in 15% of wings.

(Marenda et al., 2004)

Mutation enhances the Egfr mutant wing phenotype, the interaction is not specific to Egfr^t1.

(Price et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

2460

107344

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

E(Egfr)C221

(Price et al., 1997)

vn^C221

(Zhu et al., 2017, Casso et al., 2011, Moses et al., 2011, Murillo-Maldonado et al., 2011, Oishi et al., 2009, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Oishi et al., 2006)

vn^c221

(Curtis et al., 2013, Rendina et al., 2010, Armstrong et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

Open Close