FlyBase Allele Report: Dmel\Bap170[hfl1]

General Information

Symbol

Dmel\Bap170^hfl1

Species

D. melanogaster

Name

FlyBase ID

FBal0248499

Feature type

allele

Associated gene

Dmel\Bap170

Associated Insertion(s)

Carried in Construct

Also Known As

hfl¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Rendina et al., 2010)

Progenitor genotype

Cytology

Description

16bp deletion in the fourth exon, resulting in a frameshift which is predicted to remove the most C-terminal 304 amino acids.

(Rendina et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:6,641,372..6,641,387 [+]

Comment:

Approximate location of 16bp deletion in Bap170^hfl1. Reported as a 16bp deletion in the fourth exon that leaves a mutated Bap170 that is deleted from the last C-terminal 304 amino acids.

(Rendina et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of prepupal stage (with Df(2R)hfl-37)

(Rendina et al., 2010)

lethal - all die before end of prepupal stage | recessive

(Rendina et al., 2010)

some die during prepupal stage | recessive

(Rendina et al., 2010)

some die during prepupal stage | recessive (with Df(2R)hfl-37)

(Rendina et al., 2010)

visible, with Bap170^C1.UAS, Scer\GAL4^Dll-md23

(Rendina et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous and Bap170^hfl1/Df(2R)hfl-37 animals show normal development and growth throughout larval life, but terminate further development within the first 12 hours of the prepupal period, with no evidence of eversion of either the imaginal discs or head capsule. Homozygous leg and wing discs start the elongation phase at 4 hours after puparium formation (as occurs in wild type), but as development proceeds, eversion outside the imago body fails and the imaginal discs remain partially elongated in the mutant prepupae.

Bap170^hfl1 adults which have been rescued by expression of Bap170^C1.Scer\UAS under the control of Scer\GAL4^Dll-md23 have eyes that are slightly larger than normal and have a rough appearance. The ommatidia often have more than the normal number of photoreceptor cells (some have extra outer photoreceptors, some have an extra putative R7 cell) and often have more than the normal four cone cells.

(Rendina et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Bap170^hfl1/Bap170[+] is an enhancer of visible phenotype of bs²

(Rendina et al., 2010)

Suppressor of

Statement

Reference

Bap170^hfl1/Bap170[+] is a suppressor of visible phenotype of pnt¹²⁷⁷/pnt^Δ88

(Rendina et al., 2010)

Bap170^hfl1 is a suppressor of visible phenotype of Ras85D^N17.sev

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor of visible phenotype of kni^ri-1

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor of visible phenotype of Raf¹²

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor of lethal | heat sensitive phenotype of Raf¹²

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor of visible phenotype of vn^C221/vn¹

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor | partially of visible phenotype of Egfr^T1/Egfr^f24

(Rendina et al., 2010)

NOT Suppressor of

Statement

Reference

Bap170^hfl1/Bap170[+] is a non-suppressor of visible phenotype of rho^ve-1

(Rendina et al., 2010)

Phenotype Manifest In

Enhancer of

Statement

Reference

Bap170^hfl1/Bap170[+] is an enhancer of wing vein | ectopic phenotype of bs²

(Rendina et al., 2010)

Suppressor of

Statement

Reference

Bap170^hfl1/Bap170[+] is a suppressor of eye photoreceptor cell phenotype of pnt¹²⁷⁷/pnt^Δ88

(Rendina et al., 2010)

Bap170^hfl1 is a suppressor of eye phenotype of Ras85D^N17.sev

(Rendina et al., 2010)

Bap170^hfl1 is a suppressor of photoreceptor cell R7 phenotype of Ras85D^N17.sev

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor of wing vein L2 | distal phenotype of kni^ri-1

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor of eye phenotype of Raf¹²

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor of photoreceptor neuron phenotype of Raf¹²

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor of wing vein L4 phenotype of vn^C221/vn¹

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor | partially of eye phenotype of Egfr^T1/Egfr^f24

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor | partially of eye photoreceptor cell phenotype of Egfr^T1/Egfr^f24

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a suppressor of wing vein L4 phenotype of Egfr^T1/Egfr^f24

(Rendina et al., 2010)

NOT Suppressor of

Statement

Reference

Bap170^hfl1/Bap170[+] is a non-suppressor of wing vein L3 | distal phenotype of rho^ve-1

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a non-suppressor of wing vein L4 phenotype of rho^ve-1

(Rendina et al., 2010)

Bap170^hfl1/Bap170[+] is a non-suppressor of wing vein L5 phenotype of rho^ve-1

(Rendina et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Bap170^hfl1 completely suppresses the rough eye phenotype and loss of photoreceptor R7 cells caused by Ras85D^N17.sev.

Bap170^hfl1/+ significantly suppresses the rough eye phenotype and loss of photoreceptor cells seen in phl¹² flies at 18[o]C.

The lethality caused by phl¹² at 25[o]C is partially rescued by Bap170^hfl1/+.

Bap170^hfl1/+ suppresses the loss of photoreceptor cells seen in pnt^Δ88/pnt¹²⁷⁷ flies.

The loss of wing vein L4 which is seen in vn¹/vn^C221 animals is rescued by Bap170^hfl1/+ in 90% of cases.

Bap170^hfl1/+ partially suppresses the rough eye phenotype and loss of photoreceptor cells which is seen in Egfr^f24/Egfr^T1 flies. The loss of wing vein L4 which is seen in Egfr^f24/Egfr^T1 flies is rescued by Bap170^hfl1/+ in 85% of cases.

Bap170^hfl1/+ enhances the ectopic wing vein phenotype of bs² homozygotes.

The loss of the distal part of wing vein L2 which is seen in kni^ri-1 homozygotes is almost completely suppressed by Bap170^hfl1/+ in 95% of cases.

The loss of wing veins seen in rho^ve-1 homozygotes is not suppressed by Bap170^hfl1/+.

(Rendina et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Bap170^hfl1 is rescued by Bap170^+Ra

(Rendina et al., 2010)

Bap170^hfl1 is rescued by Bap170^C1.UAS/Scer\GAL4^Tub.PU

(Rendina et al., 2010)

Partially rescued by

Bap170^hfl1 is partially rescued by Bap170^C1.UAS/Scer\GAL4^Dll-md23

(Rendina et al., 2010)

Not rescued by

Bap170^hfl1 is not rescued by Scer\GAL4^Tub.PU/Bap170^C2.UAS

(Rendina et al., 2010)

Comments

Bap170^+Ra rescues the lethality of Bap170^hfl1 homozygotes.

Expression of Bap170^C1.Scer\UAS under the control of Scer\GAL4^tub.PU rescues the lethality of Bap170^hfl1 homozygotes.

Expression of Bap170^C2.Scer\UAS under the control of Scer\GAL4^tub.PU fails to rescue the lethality of Bap170^hfl1 homozygotes.

Expression of Bap170^C1.Scer\UAS under the control of Scer\GAL4^Dll-md23 rescues the prepupal lethality of Bap170^hfl1 homozygotes.

(Rendina et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Bap170^hfl1 was originally isolated as a lethal mutation on a second chromosome which also carries cl^9d1.

(Rendina et al., 2010)

Separable from: cl^9d1.

(Rendina et al., 2010)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Bap170^hfl1

bap170^hfl1

(Rendina et al., 2010)

hfl¹

(Shidlovskii et al., 2021, Rendina et al., 2010, Rendina et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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