FlyBase Allele Report: Dmel\Egfr[T1]

General Information

Symbol

Dmel\Egfr^T1

Species

D. melanogaster

Name

FlyBase ID

FBal0248505

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with Egfr^f24)

(Rendina et al., 2010)

Phenotype Manifest In

eye (with Egfr^f24)

(Rendina et al., 2010)

eye photoreceptor cell (with Egfr^f24)

(Rendina et al., 2010)

wing vein L4 (with Egfr^f24)

(Rendina et al., 2010)

Detailed Description

Statement

Reference

Egfr^T1 mutants do not show any alteration in mortality as a result of WNV-Kun infection when compared to controls.

(Ahlers et al., 2019)

Egfr^f24/Egfr^T1 flies have severe rough eyes which have a reduced number of photoreceptor cells per ommatidium. Most of vein L4 is lost in the wing.

(Rendina et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Egfr^T1/Egfr^f24 has visible phenotype, enhanceable by Bap170^C1.UAS/Scer\GAL4^Bx-MS1096

(Rendina et al., 2010)

Suppressed by

Statement

Reference

Egfr^T1/Egfr^f24 has visible phenotype, suppressible | partially by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Egfr^T1/Egfr^f24 has wing vein L4 phenotype, enhanceable by Bap170^C1.UAS/Scer\GAL4^Bx-MS1096

(Rendina et al., 2010)

Suppressed by

Statement

Reference

Egfr^T1/Egfr^f24 has eye phenotype, suppressible | partially by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

Egfr^T1/Egfr^f24 has eye photoreceptor cell phenotype, suppressible | partially by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

Egfr^T1/Egfr^f24 has wing vein L4 phenotype, suppressible by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

Other

Statement

Reference

Bap170^C1.UAS, Egfr^T1/Egfr^f24, Scer\GAL4^Bx-MS1096 has wing vein L3 phenotype

(Rendina et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Bap170^hfl1/+ partially suppresses the rough eye phenotype and loss of photoreceptor cells which is seen in Egfr^f24/Egfr^T1 flies. The loss of wing vein L4 which is seen in Egfr^f24/Egfr^T1 flies is rescued by Bap170^hfl1/+ in 85% of cases.

(Rendina et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Egfr^T1

(Rendina et al., 2010)

egfr^t1

(Ahlers et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close