5bp deletion causing a frameshift in the C-terminal region of the protein.
Mutation within the 5' regulatory sequence.
Amino acid replacement: W238R. Previously thought to be an insertion into the promoter, but this result was not reproducible. A mutation was detected but this corresponds to a wild type polymorphism.
4kb DNA insertion.
Expression of S6kIIScer\UAS.T:Hsap\MYC, under the control of Scer\GAL4GMR.PF, causes a more severe roughened-eye phenotype and a greater loss of rhabdomeres when expressed in a phl12/+ background than when expressed in a wild-type background.
The eye roughness and decreased rhabdomere phenotypes seen in phl12 flies are suppressed in phl12, S6kIID1/Y flies. The male temperature sensitive lethality of phl12/Y flies is suppressed in phl12/Y, S6kIID1/Y flies.
At 28oC, less than 3% lamellocytes are seen in phl12 hopTum larvae. Plasmatocytes with abnormal morphology are occasionally seen in these animals; some blood cells are larger than the plasmatocytes normally seen in wild-type larvae, while others have processes or an elongated morphology. The overproliferation of blood cells seen in hopTum larvae is not suppressed by phl12. phl12 hopTum larvae have reduced melanotic tumour formation compared to hopTum larvae, but the lymph glands are still overgrown.
Phenotype can be slightly rescued (60-70% ommatidia have wild-type complement of photoreceptor cells) by JraS82D.T92D.T107D.hs.sev.
Reduced viability is dominantly suppressed by rlSem. Surviving flies have a reduced number of photoreceptors.