FlyBase Allele Report: Dmel\phyl[1]

General Information

Symbol

Dmel\phyl¹

Species

D. melanogaster

Name

FlyBase ID

FBal0044254

Feature type

allele

Associated gene

Dmel\phyl

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Dickson et al., 1995)

Mutagen

ethyl methanesulfonate

(Dickson et al., 1996, Dickson et al., 1995)

Progenitor genotype

Cytology

Description

Point mutation leading to premature termination of translation.

(Dickson et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Pi et al., 2001, Dickson et al., 1996, Dickson et al., 1995)

lethal - all die during embryonic stage (with phyl²)

(Pi et al., 2004)

lethal - all die during first instar larval stage (with phyl²)

(Pi et al., 2004)

partially lethal - majority live (with phyl⁴)

(Pi et al., 2001)

visible (with phyl⁴)

(Pi et al., 2001)

Phenotype Manifest In

adult abdominal segment 3 & chaeta (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 3 & microchaeta (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 3 & tormogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 3 & trichogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 4 & chaeta (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 4 & microchaeta (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 4 & tormogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

adult abdominal segment 4 & trichogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

eo neuron | embryonic stage (with phyl²)

(Pi et al., 2001)

mesothoracic tergum & chaeta (with phyl⁴)

(Pi et al., 2001)

mesothoracic tergum & microchaeta (with phyl⁴)

(Pi et al., 2001)

mesothoracic tergum & tormogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

mesothoracic tergum & trichogen cell | supernumerary (with phyl⁴)

(Pi et al., 2001)

photoreceptor cell R1

(Dickson et al., 1995)

photoreceptor cell R6

(Dickson et al., 1995)

photoreceptor cell R7

(Dickson et al., 1995)

thecogen cell | embryonic stage (with phyl²)

(Pi et al., 2001)

Detailed Description

Statement

Reference

phyl¹/phyl² animals die at late embryonic or first larval instar stages.

(Pi et al., 2004)

78% of the notal microchaetae and 87% of the microchaetae on abdominal segments 3 and 4 are missing in phyl¹/phyl⁴ flies. 45% of bristles on the notum are duplicated, having 2 hairs emerging from 2 sockets or a fused socket, and 28% of bristles on the notum show other defects (including 1 hair surrounded by 2-3 sockets, and 2 socket or 4 socket clusters without shafts). 1% of bristles on abdominal segments 3 and 4 are duplicated (2 hairs/2 sockets) and 20% show other defects. 75% of the neurons and 50% of the sheath cells of the es organs are missing in phyl¹/phyl² embryos, although most es organs form.

(Pi et al., 2001)

In clones of phyl¹ cells ommatidia contain only 5 photoreceptor cells, an R8 and four cells of the R1-6 class. Rare ommatidia have five R1-R6 cells. Missing receptor cells are transformed to cone cells. Clonal analysis reveals that phyl is required only in R1, R6 and R7.

(Dickson et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

phyl¹/phyl² has eo neuron | embryonic stage phenotype, suppressible by ttk[+]/ttk^osn

(Pi et al., 2001)

Enhancer of

Statement

Reference

phyl¹ is an enhancer of eye phenotype of Raf¹²

(Dickson et al., 1996)

phyl¹ is an enhancer of photoreceptor cell R1 phenotype of Raf¹²

(Dickson et al., 1995)

phyl¹ is an enhancer of photoreceptor cell R2 phenotype of Raf¹²

(Dickson et al., 1995)

phyl¹ is an enhancer of photoreceptor cell R3 phenotype of Raf¹²

(Dickson et al., 1995)

phyl¹ is an enhancer of photoreceptor cell R4 phenotype of Raf¹²

(Dickson et al., 1995)

phyl¹ is an enhancer of photoreceptor cell R5 phenotype of Raf¹²

(Dickson et al., 1995)

phyl¹ is an enhancer of photoreceptor cell R6 phenotype of Raf¹²

(Dickson et al., 1995)

phyl¹ is an enhancer of photoreceptor cell R7 phenotype of Raf¹²

(Dickson et al., 1995)

NOT Enhancer of

Statement

Reference

phyl¹/phyl² is a non-enhancer of sensory neuron | increased number phenotype of ttk^osn

(Pi et al., 2001)

Suppressor of

Statement

Reference

phyl¹ is a suppressor of eye phenotype of Raf::tor^12D.hs.sev

(Dickson et al., 1996)

phyl¹ is a suppressor of photoreceptor cell R7 phenotype of Raf::tor^12D.hs.sev

(Dickson et al., 1995)

NOT Suppressor of

Statement

Reference

phyl¹/phyl² is a non-suppressor of sensory neuron | increased number phenotype of ttk^osn

(Pi et al., 2001)

Other

Statement

Reference

Raf::tor^12D.sev, phyl¹ has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

phyl¹, sev^{Y1485A.W1486A.sev} has photoreceptor cell R7 phenotype

(Dickson et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

N^l1N-ts1 ; phyl¹/phyl² embryos show a reduction in the number of neurons in each abdominal hemisegment.

(Pi et al., 2001)

Dominantly suppresses the rough eye phenotype of phl::tor^12D.hs.sev. Modifies the eye phenotype of phl¹².

(Dickson et al., 1996)

Suppresses rough eye phenotype of phl::tor^12D.hs.sev, almost completely eliminating the extra R7 cells. Dominantly enhances the photoreceptor phenotype of phl¹² and 'sev³⁵¹'.

(Dickson et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

phyl¹/phyl² is rescued by phyl^+t15

(Dickson et al., 1995)

phyl¹ is rescued by phyl^+t15

(Dickson et al., 1995)

Partially rescued by

phyl¹/phyl² is partially rescued by phyl^3.4.ORF

(Pi et al., 2004)

phyl¹/phyl² is partially rescued by phyl^4.1.ORF

(Pi et al., 2004)

Not rescued by

phyl¹/phyl² is not rescued by phyl^3.4ΔES.ORF

(Pi et al., 2004)

phyl¹/phyl² is not rescued by phyl^3.4ΔE.ORF

(Pi et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

phyl¹

phyl^3G6

(Dickson et al., 1996)

Name Synonyms

Secondary FlyBase IDs

References (4)

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