FlyBase Allele Report: Dmel\sev[Y1485A.W1486A.sev]

General Information

Symbol

Dmel\sev^{Y1485A.W1486A.sev}

Species

D. melanogaster

Name

FlyBase ID

FBal0056182

Feature type

allele

Associated gene

Dmel\sev

Associated Insertion(s)

Carried in Construct

P{sE-sev^{Y1485A.W1486A}}

Key Links

Transgenic product class

missense_variant

(Raabe et al., 1995)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Raabe et al., 1995)

Mutagen

in vitro construct

(van der Straten et al., 1997, Dickson et al., 1995, Raabe et al., 1995)

Progenitor genotype

Carried in construct

P{sE-sev^{Y1485A.W1486A}}

Cytology

Description

Construct: Amino acid replacement: Y1485A. Amino acid replacement: W1486A. Mutant sev cDNA.

(Dickson et al., 1995)

Duplicated sev enhancer drives expression of a mutant sev cDNA which carries the amino acid replacements Y1485A and W1486A.

(Raabe et al., 1995)

Allele components

Component

Use(s)

Regulatory region(s)

sev

Encoded product / tool

sev

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

photoreceptor cell R7

(Dickson et al., 1995)

Detailed Description

Statement

Reference

sev¹⁴ mutants partially rescued by sev^{Y1485A.W1486A.sev} are referred to as 'sev³⁵¹' flies. 'sev³⁵¹' flies exhibit reduction in numbers of R7 cells per ommatidium.

(Dickson et al., 1995)

Number of R7 cells in 'sev³⁵¹' flies per ommatidium is 0.81 +/- 0.06 (n=354).

(Raabe et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

phyl¹, sev^{Y1485A.W1486A.sev} has photoreceptor cell R7 phenotype

(Dickson et al., 1995)

phyl², sev^{Y1485A.W1486A.sev} has photoreceptor cell R7 phenotype

(Dickson et al., 1995)

phyl³, sev^{Y1485A.W1486A.sev} has photoreceptor cell R7 phenotype

(Dickson et al., 1995)

phyl⁴, sev^{Y1485A.W1486A.sev} has photoreceptor cell R7 phenotype

(Dickson et al., 1995)

phyl⁵, sev^{Y1485A.W1486A.sev} has photoreceptor cell R7 phenotype

(Dickson et al., 1995)

phyl⁶, sev^{Y1485A.W1486A.sev} has photoreceptor cell R7 phenotype

(Dickson et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

The phenotype of 'sev³⁵¹' flies is dominantly enhanced by phyl mutants.

(Dickson et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

sev^{Y1485A.W1486A.sev} partially rescues sev¹⁴

(van der Straten et al., 1997)

sev^{Y1485A.W1486A.sev} partially rescues sev¹⁴

(Dickson et al., 1995)

Comments

'sev³¹⁵' flies are sev¹⁴ mutants partially rescued by sev^{Y1485A.W1486A.sev}.

(van der Straten et al., 1997)

sev¹⁴ mutants partially rescued by sev^{Y1485A.W1486A.sev} are referred to as 'sev³⁵¹' flies.

(Dickson et al., 1995)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sev³⁵¹

sev^{Y1485A.W1486A.sev}

Name Synonyms

Secondary FlyBase IDs

FBal0044335

References (3)

Report Sections

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