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General Information
Symbol
Dmel\phyl2
Species
D. melanogaster
Name
FlyBase ID
FBal0044256
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Point mutation leading to premature termination of translation.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

adult abdominal segment 3 & chaeta (with phyl4)

adult abdominal segment 3 & microchaeta (with phyl4)

adult abdominal segment 3 & tormogen cell | supernumerary (with phyl4)

adult abdominal segment 3 & trichogen cell | supernumerary (with phyl4)

adult abdominal segment 4 & chaeta (with phyl4)

adult abdominal segment 4 & microchaeta (with phyl4)

adult abdominal segment 4 & tormogen cell | supernumerary (with phyl4)

adult abdominal segment 4 & trichogen cell | supernumerary (with phyl4)

mesothoracic tergum & chaeta (with phyl4)

mesothoracic tergum & microchaeta (with phyl4)

mesothoracic tergum & tormogen cell | supernumerary (with phyl4)

mesothoracic tergum & trichogen cell | supernumerary (with phyl4)

Detailed Description
Statement
Reference

phyl1/phyl2 animals die at late embryonic or first larval instar stages.

phyl2/Df(2R)trix embryos show loss of the LL1 and DO4 muscles.

The number of notal microchaetae and microchaetae on abdominal segments 3 and 4 are reduced in phyl2/phyl4 flies. 58% of bristles on the notum are duplicated, having 2 hairs emerging from 2 sockets or a fused socket, and 9.2% of bristles on the notum show other defects (including 1 hair surrounded by 2-3 sockets, and 2 socket or 4 socket clusters without shafts). 6.7% of bristles on abdominal segments 3 and 4 are duplicated (2 hairs/2 sockets) and 11.6% show other defects. Homozygous clones in the notum lack most bristles and the few remaining ones have a four socket phenotype. 75% of the neurons and 50% of the sheath cells of the es organs are missing in phyl1/phyl2 embryos, although most es organs form.

Embryos derived from homozygous germline clones show defects dissimilar to those caused by defective tor signalling: head skeleton and filzkorper are abnormal.

Ommatidia of phyl2/phyl4 flies contain only 5 photoreceptor cells, an R8 and four cells of the R1-6 class. Rare ommatidia have five R1-R6 cells. This phenotype is also seen in clones of phyl2 cells. Missing receptor cells are transformed to cone cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

phyl2/phyl4 has visible phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has visible phenotype, enhanceable by ttk[+]/ttkosn

Suppressed by
Statement
Reference

phyl2/phyl4 has visible phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has visible phenotype, suppressible by ttk[+]/ttkosn

NOT suppressed by
Statement
Reference

phyl2 has visible | somatic clone phenotype, non-suppressible by Scer\GAL4Eq/sensUAS.cNa

Enhancer of
Statement
Reference

phyl2/phyl[+] is an enhancer of visible phenotype of sina3/sina2

Phenotype Manifest In
Enhanced by
Statement
Reference

phyl2/phyl4 has adult abdominal segment 3 & chaeta phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 3 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 4 & chaeta phenotype, enhanceable by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 4 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 4 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 3 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 3 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 4 & chaeta phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 4 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 4 & trichogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 3 & chaeta phenotype, enhanceable by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 3 & tormogen cell | supernumerary phenotype, enhanceable by ttk[+]/ttkosn

Suppressed by
Statement
Reference

phyl2/phyl4 has adult abdominal segment 3 & microchaeta phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has mesothoracic tergum & chaeta phenotype, suppressible by ttk[+]/ttkosn

phyl2/phyl4 has mesothoracic tergum & microchaeta phenotype, suppressible by ttk[+]/ttkosn

phyl2/phyl4 has mesothoracic tergum & tormogen cell | supernumerary phenotype, suppressible by ttk[+]/ttkosn

phyl2/phyl4 has mesothoracic tergum & trichogen cell | supernumerary phenotype, suppressible by ttk[+]/ttkosn

phyl1/phyl2 has eo neuron | embryonic stage phenotype, suppressible by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 4 & microchaeta phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has mesothoracic tergum & chaeta phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has mesothoracic tergum & microchaeta phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has mesothoracic tergum & tormogen cell | supernumerary phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has mesothoracic tergum & trichogen cell | supernumerary phenotype, suppressible by ttk[+]/ttk1e11

phyl2/phyl4 has adult abdominal segment 3 & microchaeta phenotype, suppressible by ttk[+]/ttkosn

phyl2/phyl4 has adult abdominal segment 4 & microchaeta phenotype, suppressible by ttk[+]/ttkosn

NOT suppressed by
Statement
Reference

phyl2 has chaeta | somatic clone phenotype, non-suppressible by Scer\GAL4Eq/sensUAS.cNa

Enhancer of
Statement
Reference

phyl2/phyl[+] is an enhancer of adult abdominal segment 3 & chaeta phenotype of sina3/sina2

phyl2/phyl[+] is an enhancer of adult abdominal segment 3 & microchaeta phenotype of sina3/sina2

phyl2/phyl[+] is an enhancer of adult abdominal segment 4 & chaeta phenotype of sina3/sina2

phyl2/phyl[+] is an enhancer of adult abdominal segment 4 & microchaeta phenotype of sina3/sina2

phyl2/phyl[+] is an enhancer of mesothoracic tergum & chaeta phenotype of sina3/sina2

phyl2/phyl[+] is an enhancer of mesothoracic tergum & microchaeta phenotype of sina3/sina2

phyl2/phyl[+] is an enhancer of mesothoracic tergum & tormogen cell | supernumerary phenotype of sina3/sina2

phyl2/phyl[+] is an enhancer of mesothoracic tergum & trichogen cell | supernumerary phenotype of sina3/sina2

phyl2 is an enhancer of eye phenotype of Raf12

phyl2 is an enhancer of photoreceptor cell R1 phenotype of Raf12

phyl2 is an enhancer of photoreceptor cell R2 phenotype of Raf12

phyl2 is an enhancer of photoreceptor cell R3 phenotype of Raf12

phyl2 is an enhancer of photoreceptor cell R4 phenotype of Raf12

phyl2 is an enhancer of photoreceptor cell R5 phenotype of Raf12

phyl2 is an enhancer of photoreceptor cell R6 phenotype of Raf12

phyl2 is an enhancer of photoreceptor cell R7 phenotype of Raf12

NOT Enhancer of
Statement
Reference

phyl1/phyl2 is a non-enhancer of sensory neuron | supernumerary phenotype of ttkosn

Suppressor of
Statement
Reference

phyl2 is a suppressor of eye phenotype of Raf::tor12D.sev

NOT Suppressor of
Statement
Reference

phyl1/phyl2 is a non-suppressor of sensory neuron | supernumerary phenotype of ttkosn

Other
Additional Comments
Genetic Interactions
Statement
Reference

phyl2/+ ; sinah1/sinah1 flies have no visible mutant phenotype.

Expression of sensScer\UAS.cNa under the control of Scer\GAL4Eq1 fails to rescue external sensory organ formation in homozygous phyl2 clones in the notum.

Nl1N-ts1 ; phyl1/phyl2 embryos show a reduction in the number of neurons in each abdominal hemisegment.

Dominantly suppresses the rough eye phenotype of phl::tor12D.sev.

Suppresses rough eye phenotype of phl::tor12D.hs.sev, almost completely eliminating the extra R7 cells. Dominantly enhances the photoreceptor phenotype of phl12 and 'sev351'.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

phyl1/phyl2 is partially rescued by phyl3.4.ORF

phyl1/phyl2 is partially rescued by phyl4.1.ORF

Not rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (9)