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General Information
Symbol
Dmel\Hsp8319F2
Species
D. melanogaster
Name
FlyBase ID
FBal0049164
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
19F2
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C3194640T

Amino acid change:

R48C | Hsp83-PA; R48C | Hsp83-PB

Reported amino acid change:

R48C

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: R48C.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hsp8319F2/Hsp83e6A females have a series of ovarian defects. Approximately 75% of egg chambers are blocked at different developmental stages, not later than stage 9. The remaining egg chambers show a pronounced defect in the transfer of nurse cell cytoplasm to the oocyte; the nuclei of the nurse cells do not degenerate at the end of the dumping process, as occurs in wild-type egg chambers, but persist up to later stages of oogenesis. Mutant mature eggs are smaller in size than normal and have altered dorsal appendages.

Hsp8319F2 has no effect on an invariant bristle trait (thoracic and scutellar bristles were analysed). Hsp8319F2 has no significant effect on the trait mean of a variable bristle trait (the sternopleural, orbital, ocellar and vibrissa and carina bristles were analysed) compared to the background strain in which the Hsp8319F2 mutation was induced.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

Hsp8319F2/Hsp83[+] is an enhancer of egg chamber phenotype of cup15

Hsp8319F2/Hsp83[+] is an enhancer of egg chamber phenotype of cup21

Suppressor of
Statement
Reference

Hsp8319F2/Hsp83[+] is a suppressor of arista | increased number phenotype of obk1

Hsp8319F2 is a suppressor of eye phenotype of Raf::tor12D.sev

Other
Statement
Reference

Hsp8319F2/Hsp83[+], cup21 has egg chamber phenotype

Additional Comments
Genetic Interactions
Statement
Reference

The oogenesis defects seen in cup21 females are enhanced if they are also heterozygous for Hsp8319F2; double mutants show earlier egg chamber growth arrest and precocious degeneration of the nurse cell nuclei. The double mutant egg chambers are often misshapen, with egg chambers either unbudded or fused (seen by the presence of supernumerary nurse cell nuclei in the egg chamber).

The oogenesis defects seen in cup15 females are enhanced if they are also heterozygous for Hsp8319F2.

Dominantly suppresses the rough eye phenotype of phl::tor12D.sev. Synthetic lethal in combination with phl12.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Hsp8313F3 and Hsp8319F2 are independent isolates of the same point mutation.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)