FlyBase Allele Report: Dmel\obk[1]

General Information

Symbol

Dmel\obk¹

Species

D. melanogaster

Name

FlyBase ID

FBal0137133

Feature type

allele

Associated gene

obk

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Dworkin et al., 2001)

Phenotype Manifest In

antenna

(Dworkin et al., 2001)

arista | increased number

(Atallah et al., 2004, Dworkin et al., 2001)

eye

(Dworkin et al., 2001)

head & macrochaeta

(Dworkin et al., 2001)

maxillary palp

(Dworkin et al., 2001)

maxillary segment

(Dworkin et al., 2001)

second segment of antenna | increased number

(Dworkin et al., 2001)

third segment of antenna | increased number

(Dworkin et al., 2001)

wing vein

(Dworkin et al., 2001)

Detailed Description

Statement

Reference

obk¹ expressivity is affected by natural variation as shown by comparison in the background of eight distinct newly isolated wild caught third chromosomes. In addition arista number decreases with larval density.

(Atallah et al., 2004)

Mutants show a duplicated second, third and sixth/arista antennal segments. The effect varies and may not affect all segments. Sometimes triplications occur. Maxillary structures may be duplicated or absent, eyes may be reduced and bristles on the face may be abnormal.

(Dworkin et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Antp^73b, hth^dtl-S142204, obk¹ has visible phenotype

(Dworkin et al., 2001)

Antp^Ns, hth^dtl-S142204, obk¹ has visible phenotype

(Dworkin et al., 2001)

obk¹, ss^a has visible phenotype

(Dworkin et al., 2001)

Antp^hs.PHTA, obk¹ has visible phenotype

(Dworkin et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

obk¹ has arista | increased number phenotype, enhanceable by Hsp83^e6D/Hsp83[+]

(Atallah et al., 2004)

Suppressed by

Statement

Reference

obk¹ has arista | increased number phenotype, suppressible by l(2)gd1^d7

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, suppressible by wg^l-16

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, suppressible by wg^l-17

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, suppressible by dpp^d12

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, suppressible by Hsp83⁰⁸⁴⁴⁵/Hsp83[+]

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, suppressible by Hsp83^19F2/Hsp83[+]

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, suppressible by Hsp83^P582/Hsp83[+]

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, suppressible by Hsp83^j5C2/Hsp83[+]

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, suppressible by ex^brl

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, suppressible by ft⁴

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, suppressible by ft⁸

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, suppressible by hyd¹⁵

(Atallah et al., 2004)

NOT suppressed by

Statement

Reference

obk¹ has arista | increased number phenotype, non-suppressible by dpp^d5

(Atallah et al., 2004)

obk¹ has arista | increased number phenotype, non-suppressible by wg^l-8

(Atallah et al., 2004)

Other

Statement

Reference

Antp^73b, hth^dtl-S142204, obk¹ has leg | ectopic phenotype

(Dworkin et al., 2001)

Antp^73b, hth^dtl-S142204, obk¹ has antenna phenotype

(Dworkin et al., 2001)

Antp^Ns, hth^dtl-S142204, obk¹ has leg | ectopic phenotype

(Dworkin et al., 2001)

Antp^Ns, hth^dtl-S142204, obk¹ has antenna phenotype

(Dworkin et al., 2001)

obk¹, ss^a has leg | ectopic phenotype

(Dworkin et al., 2001)

obk¹, ss^a has antenna phenotype

(Dworkin et al., 2001)

Antp^hs.PHTA, obk¹ has leg | ectopic phenotype

(Dworkin et al., 2001)

Antp^hs.PHTA, obk¹ has antenna phenotype

(Dworkin et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

obk¹, Antp^73b (or Antp^Ns), hth^dtl-S142204 triple mutants produce biramous antenna/legs in place of single antennae. Biramous appendages also appear in obk¹, ss^a combinations. obk¹, Antp^hs.PHTA produces bi- or polyramous appendages with both antenna and leg combinations after heat shocks of 40 min duration at either 56 or 60 hours after hatch.

(Dworkin et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Partially complements: en^E. en^E fails to complement the wing venation defects of obk¹ but complements the antennal duplciation and eye bristle phenotype.

(Dworkin et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

obk¹

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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