FlyBase Allele Report: Dmel\dpp[d5]

General Information

Symbol

Dmel\dpp^d5

Species

D. melanogaster

Name

FlyBase ID

FBal0003002

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Also Known As

dpp⁵

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Spencer et al., 1982)

Description

Alterations in the disk regulatory region of dpp gene.

(Capdevila et al., 1994)

Breakpoint allele.

(St. Johnston et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die (with dpp^hr56)

(Twombly et al., 2009)

viable (with dpp^s-hc1)

(Stultz et al., 2005)

viable (with dpp^TgR46.1)

(Stultz et al., 2005)

visible

(Eivers et al., 2011, Masucci et al., 1990, St. Johnston et al., 1990, Bryant, 1988)

visible (with dpp^d6)

(Bangi and Wharton, 2006)

visible (with dpp^d12)

(Bangi and Wharton, 2006, de Navas et al., 2006, Gorfinkiel et al., 2003, Capdevila et al., 1994)

visible (with dpp^hr4)

(Zeng et al., 2007, Bangi and Wharton, 2006)

visible (with dpp^hr27)

(Adachi-Yamada et al., 1999)

visible (with dpp^hr56)

(Zeng et al., 2007, Bangi and Wharton, 2006, Ray and Wharton, 2001, Adachi-Yamada et al., 1999)

visible | recessive

(Capdevila et al., 1994)

Phenotype Manifest In

aedeagus | increased number (with dpp^d12)

(Gorfinkiel et al., 2003)

anterior crossvein (with dpp^hr56)

(Liu et al., 2011)

capitellum (with dpp^d12)

(de Navas et al., 2006)

crossvein (with dpp^hr56)

(Bangi and Wharton, 2006)

discal wing cell (with dpp^hr56)

(Ray and Wharton, 2001)

eye

(Horsfield et al., 1998, Masucci et al., 1990)

female analia (with dpp^d12)

(Gorfinkiel et al., 2003)

haltere

(St. Johnston et al., 1990)

male genitalia

(St. Johnston et al., 1990)

male terminalia (with dpp^d12)

(Gorfinkiel et al., 2003)

wing

(Barrio et al., 2007, Capdevila et al., 1994, Masucci et al., 1990, St. Johnston et al., 1990, Bryant, 1988)

wing (with dpp^d6)

(Bangi and Wharton, 2006)

wing (with dpp^d12)

(Bangi and Wharton, 2006, Capdevila et al., 1994)

wing (with dpp^hr27)

(Adachi-Yamada et al., 1999)

wing (with dpp^hr56)

(Twombly et al., 2009, Adachi-Yamada et al., 1999)

wing | distal

(de Celis et al., 1996)

wing cell (with dpp^hr4)

(Zeng et al., 2007)

wing cell (with dpp^hr56)

(Zeng et al., 2007)

wing disc

(Buratovich and Bryant, 1995)

wing margin bristle | ectopic

(Eivers et al., 2011)

wing vein (with dpp^hr4)

(Zeng et al., 2007)

wing vein (with dpp^hr56)

(Zeng et al., 2007)

wing vein L2 (with dpp^hr4)

(Bangi and Wharton, 2006)

wing vein L2 (with dpp^hr56)

(Bangi and Wharton, 2006)

wing vein L4 (with dpp^hr4)

(Bangi and Wharton, 2006)

wing vein L4 (with dpp^hr56)

(Ray and Wharton, 2001)

wing vein L5 (with dpp^hr56)

(Ray and Wharton, 2001)

Detailed Description

Statement

Reference

Mutant flies have ectopic anterior wing margin bristles.

(Eivers et al., 2011)

The anterior crossvein is absent in dpp^hr56/dpp^d5 wings.

(Liu et al., 2011)

dpp^d5/dpp^hr56 mutants show abnormal wing phenotypes and reduced viability.

(Twombly et al., 2009)

Wings are small with reduced venation.

(Barrio et al., 2007)

Heterozygotes do not have an ectopic wing vein phenotype.

(Ramel et al., 2007)

dpp^d5/dpp^hr56 flies show reductions in wing vein spacing and loss of wing veins.

dpp^d5/dpp^hr4 flies show reductions in wing vein spacing and loss of wing veins.

(Zeng et al., 2007)

The wings of dpp^d5/dpp^hr56 transheterozygotes show a truncation of the L2 vein (40% penetrance), reduction of the L4-L5 intervein (48% penetrance) and partial fusion of the L4-L5 intervein (52% penetrance). dpp^d5/dpp^hr4 wings show a truncation of both the L2 and L4 veins. The wings of dpp^d5/dpp^d6 and dpp^d5/dpp^d12 mutants are so small that the identification of patterning defects is obscured.

(Bangi and Wharton, 2006)

The size of the capitellum of the haltere is reduced in dpp^d5/dpp^d12 adults compared to wild type.

(de Navas et al., 2006)

dpp^d5/dpp^d12 females have normal vaginal plates and tergite eight, showing discretely reduced analia in a few cases. dpp^d5/dpp^d12 males have extensively reduced terminalia and the penis apparatus can be duplicated or triplicated.

(Gorfinkiel et al., 2003)

dpp^d5/dpp^hr56 flies show loss of wing veins L2 and L4 and loss of the intervein region between veins L4 and L5.

(Ray and Wharton, 2001)

The distance between veins L4 and L5 is reduced in dpp^d5/dpp^hr27 flies. dpp^hr56/dpp^d5 flies occasionally show notching of the wing margin.

(Adachi-Yamada et al., 1999)

Small, rough eyes.

(Horsfield et al., 1998)

Heterozygotes are phenotypically wild-type.

(Khalsa et al., 1998)

Extremely reduced wings, only proximal structures are identifiable. dpp^d4/dpp^d5 transheterozygote wings exhibit underdeveloped second wing vein and the fourth and fifth vein are closer and partly fused.

(de Celis et al., 1996)

Homozygotes show no leg disruptions, extensive cell death in the wing disc causes a greatly reduced wing.

(Buratovich and Bryant, 1995)

Reduced wings. Heterozygotes with dpp^d12 have reduced wings. Reduced wings. dpp^d5/dpp^d12 heterozygotes have reduced wings. Some dpp^d12 ptc^G20/dpp^d5 ptc¹⁶ individuals eclose and show a partial rescue of the ptc phenotype (decrease in the numbers of bristles on the notum, legs and antennae and number of teeth in the male sex comb and a reduction in size of overgrown structures).

(Capdevila et al., 1994)

Reduces size wing blade and slightly reduces size eye.

(Masucci et al., 1990)

Lack large portion wing blade, haltere and male genitalia.

(St. Johnston et al., 1990)

Wing blade is reduced.

(Bryant, 1988)

Heterozygotes with dpp^hr4 or dpp^hr27 exhibit wings with a deletion of the anterior crossvein.

(Spencer et al., 1982)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dpp^d5/dpp^hr56 has partially lethal - majority die phenotype, enhanceable by sax⁵

(Twombly et al., 2009)

dpp^d5/dpp^hr56 has visible phenotype, enhanceable by gbb¹/gbb[+]

(Bangi and Wharton, 2006)

dpp^d5 has visible | recessive phenotype, enhanceable by Scer\GAL4^32B/p38b^DN.UAS

(Adachi-Yamada et al., 1999)

Suppressed by

Statement

Reference

dpp^d5/dpp^d12 has visible phenotype, suppressible | partially by Ubx¹³⁰/Ubx[+]

(de Navas et al., 2006)

Enhancer of

Statement

Reference

dpp^d5 is an enhancer of visible | recessive phenotype of gbb⁴

(Khalsa et al., 1998)

Suppressor of

Statement

Reference

dpp^d5/dpp[+] is a suppressor of visible phenotype of Snoo^GS-C517T

(Ramel et al., 2007)

dpp^d5/dpp[+] is a suppressor | partially of visible phenotype of Scer\GAL4^Tub.PU, Snoo^GS-C517T

(Ramel et al., 2007)

dpp^d5 is a suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

dpp^d5, ix¹ has neoplasia phenotype

(Chatterjee et al., 2015)

dpp^d5/dpp^d6, ix¹ has neoplasia phenotype

(Chatterjee et al., 2015)

dpp^d5/dpp^d12, ix¹ has neoplasia phenotype

(Chatterjee et al., 2015)

dpp^d5/dpp^d-ho, ix¹ has neoplasia phenotype

(Chatterjee et al., 2015)

dally^ΔP-188, dpp^d5/dpp[+] has visible | dominant phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d5 has visible | dominant phenotype

(Jackson et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^d5/dpp^hr56 has crossvein phenotype, enhanceable by gbb¹/gbb[+]

(Bangi and Wharton, 2006)

dpp^d5/dpp^hr56 has wing vein L2 phenotype, enhanceable by gbb¹/gbb[+]

(Bangi and Wharton, 2006)

dpp^d5/dpp^hr4 has wing vein L2 phenotype, enhanceable by gbb¹/gbb[+]

(Bangi and Wharton, 2006)

dpp^d5 has wing phenotype, enhanceable by Scer\GAL4^32B/p38b^DN.UAS

(Adachi-Yamada et al., 1999)

Suppressed by

Statement

Reference

dpp^d5/dpp^hr56 has wing phenotype, suppressible | partially by Df(2R)H23

(Twombly et al., 2009)

dpp^d5/dpp^hr56 has wing phenotype, suppressible | partially by sax⁴

(Twombly et al., 2009)

dpp^d5/dpp^d12 has capitellum phenotype, suppressible | partially by Ubx¹³⁰/Ubx[+]

(de Navas et al., 2006)

NOT suppressed by

Statement

Reference

dpp^d5/dpp^hr56 has wing phenotype, non-suppressible by sax⁵

(Twombly et al., 2009)

Enhancer of

Statement

Reference

dpp^d5/dpp[+] is an enhancer of terminalia phenotype of ken^ok

(Lukacsovich et al., 2003)

dpp^d5 is an enhancer of anterior crossvein phenotype of gbb⁴

(Khalsa et al., 1998)

dpp^d5 is an enhancer of wing vein L4 phenotype of gbb⁴

(Khalsa et al., 1998)

Suppressor of

Statement

Reference

dpp^d5/dpp[+] is a suppressor of wing vein | ectopic phenotype of Snoo^GS-C517T

(Ramel et al., 2007)

dpp^d5/dpp[+] is a suppressor | partially of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, Snoo^GS-C517T

(Ramel et al., 2007)

dpp^d5 is a suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

dpp^d5 is a suppressor of leg disc phenotype of ft⁸, l(2)gd1¹

(Buratovich and Bryant, 1997)

dpp^d5/dpp^d12 is a suppressor | partially of phenotype of ptc¹⁶/ptc^G20

(Capdevila et al., 1994)

NOT Suppressor of

Statement

Reference

dpp^d5 is a non-suppressor of arista | increased number phenotype of obk¹

(Atallah et al., 2004)

Other

Statement

Reference

dpp^d5, ix¹ has terminalia phenotype

(Chatterjee et al., 2015)

dpp^d5/dpp^d6, ix¹ has terminalia phenotype

(Chatterjee et al., 2015)

dpp^d5/dpp^d12, ix¹ has terminalia phenotype

(Chatterjee et al., 2015)

dpp^d5/dpp^d-ho, ix¹ has terminalia phenotype

(Chatterjee et al., 2015)

Scer\GAL4^32B, dpp^d5/dpp^hr27, p38b^DN.UAS has wing vein L5 phenotype

(Adachi-Yamada et al., 1999)

Scer\GAL4^32B, dpp^d5/dpp^hr27, p38b^DN.UAS has wing vein phenotype

(Adachi-Yamada et al., 1999)

Scer\GAL4^32B, dpp^d5/dpp^hr27, p38b^DN.UAS has wing vein L4 phenotype

(Adachi-Yamada et al., 1999)

Scer\GAL4^32B, dpp^d5, p38b^DN.UAS has wing vein L5 phenotype

(Adachi-Yamada et al., 1999)

Scer\GAL4^32B, dpp^d5, p38b^DN.UAS has wing vein phenotype

(Adachi-Yamada et al., 1999)

Scer\GAL4^32B, dpp^d5, p38b^DN.UAS has wing vein L4 phenotype

(Adachi-Yamada et al., 1999)

dally^ΔP-188, dpp^d5/dpp[+] has eye phenotype

(Jackson et al., 1997)

dally^ΔP-188, dpp^d5/dpp[+] has antenna phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d5 has eye phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d5 has antenna phenotype

(Jackson et al., 1997)

dpp^d5, l(2)gd1¹ has metathoracic leg disc phenotype

(Buratovich and Bryant, 1995)

dpp^d5/dpp^d6, sax¹ has prothoracic unguis phenotype

(Brummel et al., 1994)

dpp^d5/dpp^d6, sax¹ has mesothoracic unguis phenotype

(Brummel et al., 1994)

dpp^d5/dpp^d6, sax¹ has metathoracic unguis phenotype

(Brummel et al., 1994)

dpp^d5/dpp^d6, sax² has prothoracic unguis phenotype

(Brummel et al., 1994)

dpp^d5/dpp^d6, sax² has mesothoracic unguis phenotype

(Brummel et al., 1994)

dpp^d5/dpp^d6, sax² has metathoracic unguis phenotype

(Brummel et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

A high frequency of tumour growth occurs below the anal plates of the terminalia in chromosomally female flies homozygous for ix¹ and dpp^d5, or homozygous for ix¹ and trans-heterozygous for dpp^d5/dpp^d6 or dpp^d5/dpp^d12 or dpp^d5/dpp^d-ho.

(Chatterjee et al., 2015)

Df(2R)H23 slightly suppresses the dpp^d5/dpp^hr56 wing phenotype.

sax⁴ slightly suppresses the dpp^d5/dpp^hr56 wing phenotype.

sax⁵ does not suppress the dpp^d5/dpp^hr56 wing phenotype. sax⁵ enhances the lethality associated with dpp^d5/dpp^hr56.

(Twombly et al., 2009)

The frequency of the Snoo^GS-C517T/Snoo^GS-C517T ectopic wing vein phenotype is significantly suppressed if the flies are also carrying one copy of dpp^d5.

The frequency of the ectopic wing vein phenotype caused by expression of Snoo^GS-C517T under the control of Scer\GAL4^tub is significantly suppressed if the flies are also carrying one copy of dpp^d5.

(Ramel et al., 2007)

dpp^d5/dpp^hr56, gbb¹/+ flies show an enhancement of the dpp^d5/dpp^hr56 wing phenotype; there is an increase in the fraction of wings with L2 or L4 defects and/or a more severe reduction of the L4-L5 intervein.

(Bangi and Wharton, 2006)

The reduced size of the capitellum seen in dpp^d5/dpp^d12 adults is partially suppressed by Ubx¹³⁰/+.

(de Navas et al., 2006)

The frequency of terminal defects in ken^ok homozygous adults is increased by dpp^d5/+.

(Lukacsovich et al., 2003)

The wing phenotype of dpp^d5/dpp^hr27 flies is strongly enhanced by two copies of p38b^DN.Scer\UAS expressed under the control of one copy of Scer\GAL4^32B; veins L4 and L5 are partially fused and the distance between veins L2 and L3 is reduced.

(Adachi-Yamada et al., 1999)

The homozygous gbb⁴ phenotype is enhanced by dpp^d5; gbb⁴ dpp^d5; gbb⁴ + flies show a significant loss of wing vein L4 and a more frequent loss of the anterior crossvein than gbb⁴ +; gbb⁴ + flies.

(Khalsa et al., 1998)

dpp^d5 suppresses the duplicative ability of second leg discs in ft⁸, l(2)gd1¹/l(2)gd1¹ mutants.

(Buratovich and Bryant, 1997)

Flies heterozygous for both dally⁰⁶⁴⁶⁴ and dpp^d5 show eye and antenna abnormalities.

(Jackson et al., 1997)

dpp^d5 l(2)gd1¹ wing and haltere discs are smaller than those from l(2)gd1¹ homozygotes and the third leg imaginal disc shows an overgrowth phenotype but are not duplicated.

(Buratovich and Bryant, 1995)

Whereas dpp^d5/dpp^d6 legs are normal, if the flies are also heterozygous for sax¹ or sax² then legs tend to lack tarsal claws.

(Brummel et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dpp^d5/dpp^d12 is rescued by dpp^αTub84B.PG

(Gorfinkiel et al., 2003)

Comments

Expression of dpp^αTub84B.PG in clones in the male terminalia in a dpp^d5/dpp^d12 background results in the recovery of terminal structures. The degree of recovery depends on the developmental stage at which the clone is induced. Recovery of terminal structures is accompanied by reduced penis apparatus duplications. The rescue is non-autonomous.

(Gorfinkiel et al., 2003)

Belongs to the disk-II class of alleles.

(St. Johnston et al., 1990)

Allele class: d-II

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

2071

dpp^d5/CyO, P{sevRas1.V12}FK1

Kyoto

106651

dpp^d5/CyO

109632

w^* P{UAS-p38b.DN}W; dpp^d5 / SM1

Notes on Origin

Discoverer

Comments

Class II dpp allele.

(Buratovich and Bryant, 1995, Spencer et al., 1982)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dpp^d5

(Eivers et al., 2011)

(Stultz et al., 2005)

dpp⁵

(Sharma et al., 2022, Sanchez et al., 1997, Spencer et al., 1982)

dpp^d5

(Malzer et al., 2018, Chatterjee et al., 2015, Dolezal et al., 2015, Huang et al., 2011, Liu et al., 2011, Twombly et al., 2009, Haley et al., 2008, Barrio et al., 2007, Ramel et al., 2007, Zeng et al., 2007, Bangi and Wharton, 2006, de Navas et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (38)

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