Open Close
General Information
Symbol
Dmel\dppd5
Species
D. melanogaster
Name
FlyBase ID
FBal0003002
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dpp5
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Alterations in the disk regulatory region of dpp gene.

Breakpoint allele.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant flies have ectopic anterior wing margin bristles.

The anterior crossvein is absent in dpphr56/dppd5 wings.

dppd5/dpphr56 mutants show abnormal wing phenotypes and reduced viability.

Wings are small with reduced venation.

Heterozygotes do not have an ectopic wing vein phenotype.

dppd5/dpphr56 flies show reductions in wing vein spacing and loss of wing veins.

dppd5/dpphr4 flies show reductions in wing vein spacing and loss of wing veins.

The wings of dppd5/dpphr56 transheterozygotes show a truncation of the L2 vein (40% penetrance), reduction of the L4-L5 intervein (48% penetrance) and partial fusion of the L4-L5 intervein (52% penetrance). dppd5/dpphr4 wings show a truncation of both the L2 and L4 veins. The wings of dppd5/dppd6 and dppd5/dppd12 mutants are so small that the identification of patterning defects is obscured.

The size of the capitellum of the haltere is reduced in dppd5/dppd12 adults compared to wild type.

dppd5/dppd12 females have normal vaginal plates and tergite eight, showing discretely reduced analia in a few cases. dppd5/dppd12 males have extensively reduced terminalia and the penis apparatus can be duplicated or triplicated.

dppd5/dpphr56 flies show loss of wing veins L2 and L4 and loss of the intervein region between veins L4 and L5.

The distance between veins L4 and L5 is reduced in dppd5/dpphr27 flies. dpphr56/dppd5 flies occasionally show notching of the wing margin.

Small, rough eyes.

Heterozygotes are phenotypically wild-type.

Extremely reduced wings, only proximal structures are identifiable. dppd4/dppd5 transheterozygote wings exhibit underdeveloped second wing vein and the fourth and fifth vein are closer and partly fused.

Homozygotes show no leg disruptions, extensive cell death in the wing disc causes a greatly reduced wing.

Reduced wings. Heterozygotes with dppd12 have reduced wings. Reduced wings. dppd5/dppd12 heterozygotes have reduced wings. Some dppd12 ptcG20/dppd5 ptc16 individuals eclose and show a partial rescue of the ptc phenotype (decrease in the numbers of bristles on the notum, legs and antennae and number of teeth in the male sex comb and a reduction in size of overgrown structures).

Reduces size wing blade and slightly reduces size eye.

Lack large portion wing blade, haltere and male genitalia.

Wing blade is reduced.

Heterozygotes with dpphr4 or dpphr27 exhibit wings with a deletion of the anterior crossvein.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference

dppd5/dppd12 has visible phenotype, suppressible | partially by Ubx130/Ubx[+]

Enhancer of
Statement
Reference

dppd5 is an enhancer of visible | recessive phenotype of gbb4

Suppressor of
Statement
Reference

dppd5/dpp[+] is a suppressor | partially of visible phenotype of Scer\GAL4[-], SnooGS-C517T

dppd5/dpp[+] is a suppressor | partially of visible phenotype of Scer\GAL4Tub.PU, SnooGS-C517T

dppd5 is a suppressor of visible phenotype of upd1GMR.PB

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

dppd5/dpphr56 has crossvein phenotype, enhanceable by gbb1/gbb[+]

dppd5/dpphr56 has wing vein L2 phenotype, enhanceable by gbb1/gbb[+]

dppd5/dpphr4 has wing vein L2 phenotype, enhanceable by gbb1/gbb[+]

Suppressed by
Statement
Reference

dppd5/dpphr56 has wing phenotype, suppressible | partially by Df(2R)H23

dppd5/dpphr56 has wing phenotype, suppressible | partially by sax4

dppd5/dppd12 has capitellum phenotype, suppressible | partially by Ubx130/Ubx[+]

NOT suppressed by
Statement
Reference

dppd5/dpphr56 has wing phenotype, non-suppressible by sax5

Enhancer of
Statement
Reference

dppd5/dpp[+] is an enhancer of terminalia phenotype of kenok

dppd5 is an enhancer of anterior crossvein phenotype of gbb4

dppd5 is an enhancer of wing vein L4 phenotype of gbb4

Suppressor of
Statement
Reference

dppd5/dpp[+] is a suppressor | partially of wing vein | ectopic phenotype of Scer\GAL4[-], SnooGS-C517T

dppd5/dpp[+] is a suppressor | partially of wing vein | ectopic phenotype of Scer\GAL4Tub.PU, SnooGS-C517T

dppd5 is a suppressor of eye phenotype of upd1GMR.PB

dppd5/dppd12 is a suppressor | partially of phenotype of ptc16/ptcG20

NOT Suppressor of
Statement
Reference

dppd5 is a non-suppressor of arista | increased number phenotype of obk1

Other
Statement
Reference

dally[+]/dally06464, dppd5 has eye phenotype

dally[+]/dally06464, dppd5 has antenna phenotype

Additional Comments
Genetic Interactions
Statement
Reference

A high frequency of tumour growth occurs below the anal plates of the terminalia in chromosomally female flies homozygous for ix1 and dppd5, or homozygous for ix1 and trans-heterozygous for dppd5/dppd6 or dppd5/dppd12 or dppd5/dppd-ho.

Df(2R)H23 slightly suppresses the dppd5/dpphr56 wing phenotype.

sax4 slightly suppresses the dppd5/dpphr56 wing phenotype.

sax5 does not suppress the dppd5/dpphr56 wing phenotype. sax5 enhances the lethality associated with dppd5/dpphr56.

The frequency of the SnooGS-C517T/SnooGS-C517T ectopic wing vein phenotype is significantly suppressed if the flies are also carrying one copy of dppd5.

The frequency of the ectopic wing vein phenotype caused by expression of SnooGS-C517T under the control of Scer\GAL4tub is significantly suppressed if the flies are also carrying one copy of dppd5.

dppd5/dpphr56, gbb1/+ flies show an enhancement of the dppd5/dpphr56 wing phenotype; there is an increase in the fraction of wings with L2 or L4 defects and/or a more severe reduction of the L4-L5 intervein.

The reduced size of the capitellum seen in dppd5/dppd12 adults is partially suppressed by Ubx130/+.

The frequency of terminal defects in kenok homozygous adults is increased by dppd5/+.

The wing phenotype of dppd5/dpphr27 flies is strongly enhanced by two copies of p38bDN.Scer\UAS expressed under the control of one copy of Scer\GAL432B; veins L4 and L5 are partially fused and the distance between veins L2 and L3 is reduced.

The homozygous gbb4 phenotype is enhanced by dppd5; gbb4 dppd5; gbb4 + flies show a significant loss of wing vein L4 and a more frequent loss of the anterior crossvein than gbb4 +; gbb4 + flies.

dppd5 suppresses the duplicative ability of second leg discs in ft8, l(2)gd11/l(2)gd11 mutants.

Flies heterozygous for both dally06464 and dppd5 show eye and antenna abnormalities.

dppd5 l(2)gd11 wing and haltere discs are smaller than those from l(2)gd11 homozygotes and the third leg imaginal disc shows an overgrowth phenotype but are not duplicated.

Whereas dppd5/dppd6 legs are normal, if the flies are also heterozygous for sax1 or sax2 then legs tend to lack tarsal claws.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of dppαTub84B.PG in clones in the male terminalia in a dppd5/dppd12 background results in the recovery of terminal structures. The degree of recovery depends on the developmental stage at which the clone is induced. Recovery of terminal structures is accompanied by reduced penis apparatus duplications. The rescue is non-autonomous.

Belongs to the disk-II class of alleles.

Allele class: d-II

Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (37)